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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

CD14 molecule

The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: CAN, HAD, CD16, TLR4, CD4
Papers using CD14 antibodies
Identification of a polyI:C-inducible membrane protein that participates in dendritic cell-mediated natural killer cell activation.
Gay Nick, In PLoS ONE, 2009
... from peripheral blood mononuclear cells obtained from healthy individuals with a magnetic cell sorting system using anti-CD14-coated microbeads (Miltenyi Biotec, Gladbach, Germany) ...
Biochemical and structural characterization of the human TL1A ectodomain
Steinberger Peter et al., In Journal of Immunological Methods, 2008
... The mAbs to CD14 (MEM-18) was purchased from An der Grub (Kaumberg, Austria), CD19 mAb ...
Neuromodulatory activities of CD4+CD25+ regulatory T cells in a murine model of HIV-1-associated neurodegeneration
Unutmaz Derya, In PLoS ONE, 2008
... monocytes were isolated by positive selection (CD14 beads, Miltenyi Biotec, Auburn, CA) and immature ...
Role of CD34 antigen in myeloid differentiation of human hematopoietic progenitor cells
Ferrari S et al., In Cell Death & Disease, 2007
... for the expression of CD14 and purified after 8 days of culture using the EasySep Human CD14-Positive Selection kit (StemCell Technologies) that yielded a purity of ...
Randomized study of high-dose and low-dose interleukin-2 in patients with metastatic renal cancer
Perez-Gracia J L et al., In British Journal of Cancer, 2007
... Isolated mononuclear cells were subjected to positive selection using anti-CD14-conjugated paramagnetic beads and purified using the AutoMACS system according to the manufacturer's instructions (Miltenyi Biotec, Bergisch Gladbach, Germany) ...
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Papers on CD14
The induction of human myeloid derived suppressor cells through hepatic stellate cells is dose-dependently inhibited by the tyrosine kinase inhibitors nilotinib, dasatinib and sorafenib, but not sunitinib.
Höchst et al., Bonn, Germany. In Cancer Immunol Immunother, Feb 2016
We show that frequencies of monocytic CD14(+)HLA-DR(-/low) MDSCs derived from mature monocytes were significantly and dose-dependently reduced in the presence of dasatinib, nilotinib and sorafenib, whereas sunitinib had no effect.
Monocyte Recruitment following High-Intensity and High-Volume Resistance Exercise.
Stout et al., Kennesaw, United States. In Med Sci Sports Exerc, Feb 2016
TNFr1 and CD11b were assessed on CD14CD16 monocytes, while CCR2 was assessed on CD14 monocytes.
IL-36R signalling activates intestinal epithelial cells and fibroblasts and promotes mucosal healing in vivo.
Neufert et al., Erlangen, Germany. In Gut, Feb 2016
While IL-36γ was predominantly detected in nuclei of the intestinal epithelium, IL-36α was mainly found in the cytoplasm of CD14(+) inflammatory macrophages.
Targeting peroxiredoxin I potentiates 1,25‑dihydroxyvitamin D3‑induced cell differentiation in leukemia cells.
Hao et al., Shanghai, China. In Mol Med Report, Feb 2016
Cell viability was assessed using a trypan blue exclusion assay and flow cytometry was used to evaluate the expression of cell surface markers, CD11b/CD14, and the level of reactive oxygen species (ROS).
Therapeutic Boosting of the Immune Response: Turning to CD14 for Help.
Labéta et al., Cardiff, United Kingdom. In Curr Pharm Biotechnol, Feb 2016
Efficient responses via TLRs require the activity of the co-receptor CD14, which enhances TLR responses.
Genomic landscapes of endogenous retroviruses unveil intricate genetics of conventional and genetically-engineered laboratory mouse strains.
Cho et al., Sacramento, United States. In Exp Mol Pathol, Feb 2016
In addition, a CD14 knock-out strain had a distinct TREome landscape compared to its control/backcross C57BL/6J strain.
Saturated fatty acids trigger TLR4-mediated inflammatory response.
Hermsdorff et al., Viçosa, Brazil. In Atherosclerosis, Jan 2016
Thus, our present review provides a new perspective on the potential mechanism by which SFAs could modulate TLR4-induced inflammatory responses: (1) SFAs can be recognized by CD14-TLR4-MD2 complex and trigger inflammatory pathways, similar to lipopolysaccharide (LPS).
The many faces of Mac-1 in autoimmune disease.
Mayadas et al., Mexico. In Immunol Rev, Jan 2016
Mac-1 (CD11b/CD18) is a β2 integrin classically regarded as a pro-inflammatory molecule because of its ability to promote phagocyte cytotoxic functions and enhance the function of several effector molecules such as FcγR, uPAR, and CD14.
Mechanisms of Toll-like Receptor 4 Endocytosis Reveal a Common Immune-Evasion Strategy Used by Pathogenic and Commensal Bacteria.
Kagan et al., Boston, United States. In Immunity, Dec 2015
Upon detection of bacterial lipopolysaccharides (LPS), CD14 induces an inflammatory endocytosis pathway that delivers Toll-like receptor 4 (TLR4) to endosomes.
Interleukin-12 and -23 Control Plasticity of CD127(+) Group 1 and Group 3 Innate Lymphoid Cells in the Intestinal Lamina Propria.
Spits et al., Amsterdam, Netherlands. In Immunity, Aug 2015
Furthermore, we observed in resection specimen from Crohn's disease patients a higher proportion of CD14(+) dendritic cells (DC), which in vitro promoted polarization from ILC3 to CD127(+) ILC1.
Lipopolysaccharide Induces Alveolar Macrophage Necrosis via CD14 and the P2X7 Receptor Leading to Interleukin-1α Release.
Arditi et al., Los Angeles, United States. In Immunity, May 2015
CD14 was required for LPS binding to P2X7R, as CD14 neutralization significantly diminished LPS induced necrotic death of AM and pro-IL-1α release.
The Interplay Between Monocytes/Macrophages and CD4(+) T Cell Subsets in Rheumatoid Arthritis.
Taams et al., London, United Kingdom. In Front Immunol, 2014
The interplay between CD14(+) myeloid cells and CD4(+) T cells can significantly influence CD4(+) T cell function, and conversely, effector vs. regulatory CD4(+) T cell subsets can exert profound effects on monocyte/macrophage function.
Immune response gene polymorphisms in tuberculosis.
Rudnicka et al., Łódź, Poland. In Acta Biochim Pol, 2014
Strong evidence exists for genes encoding pattern recognition receptors (TLR, CD14), C-type lectins, cytokines/chemokines and their receptors (IFN-γ, TNF-α, IL-12, IL-10, MCP-1, MMP-1), major histocompatibility complex (MHC) molecules, vitamin D receptor (VDR), and proton-coupled divalent metal ion transporters (SLC11A1).
A cell-intrinsic role for TLR2-MYD88 in intestinal and breast epithelia and oncogenesis.
Clarke et al., Stanford, United States. In Nat Cell Biol, 2014
Inhibition of TLR2, its co-receptor CD14, or its downstream targets MYD88 and IRAK1 inhibits growth of human breast cancers in vitro and in vivo.
The TLR4 antagonist Eritoran protects mice from lethal influenza infection.
Vogel et al., Baltimore, United States. In Nature, 2013
CD14 and TLR2 are also required for Eritoran-mediated protection, and CD14 directly binds Eritoran and inhibits ligand binding to MD2.
Lack of association of the CD14/C -- 159T polymorphism with susceptibility and progression parameters in Turkish multiple sclerosis patients.
Karabudak et al., Ankara, Turkey. In J Neuroimmunol, 2012
soluble CD14 does not appear to be a solely prominent element of innate immunity in multiple sclerosis
Differential expression of CD14-dependent and independent pathways for chemokine induction regulates neutrophil trafficking in infection.
Goyert et al., New York City, United States. In J Leukoc Biol, 2012
Stimulation of a local CD14-independent chemokine induction pathway without triggering a systemic CD14-dependent chemokine pathway can protect against severe Escherichia coli infections.
DNA methylation levels within the CD14 promoter region are lower in placentas of mothers living on a farm.
Joerink et al., Stockholm, Sweden. In Allergy, 2012
epigenetic regulation of CD14 in placenta might be involved in the protective effect of 'living on a farm', with regard to allergy development.
The role of CD14 and Toll-like receptor 4 of Kupffer cells in hepatic ischemia-reperfusion injury in rats.
Li et al., Chongqing, China. In Transplant Proc, 2012
Hepatic ischemia-reperfusion injury up-regulated CD14 and TLR4 gene expression in Kupffer cells, and subsequently activated NF-kappabeta to produce cytokines.
Association between tuberculosis and atopy: role of the CD14-159C/T polymorphism.
Ayaslioğlu et al., Turkey. In J Investig Allergol Clin Immunol, 2011
No differences were observed between atopic patients with high/low tuberculosis scores and CD14 genotypes.
More papers using CD14 antibodies
Interaction of human PD-L1 and B7-1
Ohashi Kazuhiko et al., In Veterinary Research, 2007
... gift from International Livestock Research Institute), CACT105A (mouse anti-bovine CD5: VMRD) and CAM36A (mouse anti-bovine CD14: VMRD), respectively ...
Hybridization of pulsed-Q dissociation and collision-activated dissociation in linear ion trap mass spectrometer for iTRAQ quantitation
Wong S-C et al., In Cell Death & Disease, 2007
... The Abs for flow cytometry are CD16 (3G8) (Biolegend, San Diego, CA, USA), CD14 (61D3) and cytochrome c (6H2) (eBioscience, San Diego, CA, USA) ...
MyD88- and Bruton's tyrosine kinase-mediated signals are essential for T cell-independent pathogen-specific IgM responses.
Zimmer Jacques, In PLoS ONE, 2006
... The FITC-conjugated mAbs anti-CD14, anti-CD3, and Ig isotype control antibodies were purchased from BD Biosciences (San Jose, CA) ...
A systems biology approach for pathway level analysis.
Kaul Rupert, In PLoS ONE, 2006
... Mouse anti-bovine CD14 (clone MM61A, clarified ascites fluid, 10 µg/ml) was obtained from VMRD, Inc ...
HIV-1 gp120 inhibits TLR9-mediated activation and IFN-{alpha} secretion in plasmacytoid dendritic cells.
Speck Roberto F., In PLoS ONE, 2006
... The mouse anti-human CD4 monoclonal antibody (Leu3A), antibodies against CD14, CXCR4, CCR5, and their isotype controls (IgG1 and IgG2A) were obtained from BD Biosciences (San Jose, CA) ...
The fibrin-derived gamma377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease
Wiedermann Christian J et al., In Thrombosis Journal, 2006
... Lymphoprep was from Nycomed Pharma (Oslo, Norway), anti-human CD14 antibody was from Miltenyi Biotec (Bergisch Gladbach, Germany), Bovine ...
Semen-derived amyloid fibrils drastically enhance HIV infection.
KewalRamani Vineet N., In PLoS ONE, 2006
... Monocytes were isolated using CD14 magnetic cell sorting (Miltenyi Biotec, Auburn, CA), with washing ...
Immune effects of cocoa procyanidin oligomers on peripheral blood mononuclear cells
Jutila Mark A. et al., In Genes and immunity, 2006
... Louis, MO, USA) density gradient and monocytes were removed using anti-CD14 microbeads (Miltenyi Biotec, Bergisch Gladbach, Germany) ...
Dendritic cells and NK cells stimulate bystander T cell activation in response to TLR agonists through secretion of IFN-alpha beta and IFN-gamma.
Zimmer Jacques, In PLoS ONE, 2004
... NK cells were obtained from the PBMC or CD14-negative peripheral blood lymphocyte fraction by using the human negative selection NK cell isolation kit (Miltenyi Biotec, Utrecht, The Netherlands) according ...
Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: Molecular targets are TBK1 and RIP1 in TRIF complex
Qureshi Nilofer et al., In Lipids in Health and Disease, 2004
... SuperFect transfection reagent (Flag-TLR4 wild type + pELAM-luciferase {NF-κB reporter} + β-gal reporter plasmids + MD-2 + CD14 constructs) was purchased from QIAGEN, Valencia, CA, USA ...
Decreased T-cell receptor excision circles in cutaneous T-cell lymphoma.
Speck Roberto F., In PLoS ONE, 2004
... Macrophage cultures were also established using CD14+ cells (monocytes) purified from PMBC using CD14 microbeads and a magnetic bead separation system (Miltenyi Biotec).
Heat shock protein 90 and heat shock protein 70 are components of dengue virus receptor complex in human cells
del Angel Rosa M et al., In Virology Journal, 2004
... Monocytes were purified from human PBMCs using MACS CD14 microbeads (Miltenyi Biotec) according to the manufacturer's ...
IFN-g production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo
Zheng Song Guo, In PLoS ONE, 2004
... eBioscience), mouse IgG: anti-CD3 (UCHT1, BD Biosciences), anti-CD4 (RPAT-4, BD Pharmingen), anti-CD11c (B-ly6; BD Biosciences), anti-CD14 (M5E2, BD Biosciences), anti-CD19 (HIB19, BD Biosciences), ...
Hepatocyte growth factor switches orientation of polarity and mode of movement during morphogenesis of multicellular epithelial structures
Cybulsky Myron I. et al., In The Journal of Cell Biology, 2002
... Sick Children, Toronto, Ontario, Canada), FITC- or allophycocyanin (APC)-conjugated CD49d clone 9F10 (BioLegend), APC-conjugated anti–human CD14 clone 61D3 (eBioscience), and FITC-conjugated anti–mouse CD8 ...
Small molecule integrin antagonists that bind to the beta2 subunit I-like domain and activate signals in one direction and block them in the other
de Jong Esther C et al., In Retrovirology, 2002
... Mouse anti-human mAbs were used against the following molecules: CD14 (BD Biosciences, San Jose, CA, USA), ...
Protective role of phospholipid oxidation products in endotoxin-induced tissue damage
Yamada Kazuo et al., In Journal of Clinical Biochemistry and Nutrition, 2001
... Mouse anti-iNOS monoclonal antibody and fluorescein isothiocyanate (FITC)-conjugated rat anti-mouse CD14 monoclonal antibody (CD14-FITC mAb) were purchased from BD Biosciences Pharmingen (San Diego, CA) ...
Chemokine Receptor Expression Identifies Pre–T Helper (Th)1, Pre–Th2, and Nonpolarized Cells among Human CD4+ Central Memory T Cells
Geginat Jens et al., In The Journal of Experimental Medicine, 2001
... Monocytes were purified by positive selection with anti-CD14 beads (Miltenyi Biotec).
Matrix-assisted laser desorption/ionization-tandem mass spectrometry with high resolution and sensitivity for identification and characterization of proteins.
Lewinsohn David M., In PLoS Pathogens, 2001
... ) using the following antibodies: anti-CD14-FITC (DAKO, Glastrup, Denmark), anti-CD3-PE (BD ...
Toll-like Receptor 4 Resides in the Golgi Apparatus and Colocalizes with Internalized Lipopolysaccharide in Intestinal Epithelial Cells
Richter-Dahlfors Agneta et al., In The Journal of Experimental Medicine, 2000
... The rabbit anti-CD14 antiserum (M-305) was obtained from Santa Cruz Biotechnology, Inc ...
Plug flow cytometry extends analytical capabilities in cell adhesion and receptor pharmacology
Sklar Larry A et al., In BMC Immunology, 2000
... Mouse anti-human CD14/R-PE antibodies, clone UCHM1, and isotype control mouse IgG2a/R-PE, clone RPC 5 were from Ancell Corp ...
Human foamy virus capsid formation requires an interaction domain in the N terminus of Gag
Young John A. T, In PLoS Pathogens, 2000
anti-CD14 (Clone TUK4, Miltenyi Biotec), Phycoerythrin-conjugated anti-CD25 (clone 4E3, ...
Inhibition of Interleukin 10 Signaling after Fc Receptor Ligation and during Rheumatoid Arthritis
Ivashkiv Lionel B. et al., In The Journal of Experimental Medicine, 1999
... were obtained from peripheral blood or RA synovial fluid mononuclear cells or synovial tissue, using anti-CD14 magnetic beads, as recommended by the manufacturer (Miltenyi Biotec), and were >97% pure ...
Gene ontology: tool for the unification of biology. The Gene Ontology Consortium
Sandberg Johan K., In PLoS ONE, 1999
... monocytes were positively isolated from PBMCs using anti-CD4 and anti-CD14 Ab-coated microbeads (Miltenyi Biotec) respectively, according to the ...
Tumor necrosis factor a stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interaction
Miyasaka Nobuyuki et al., In Arthritis Research & Therapy, 1999
... For the other experiment, monocytes were purified using CD14 MicroBeads (Miltenyi Biotec), and then stained either ...
A block to human immunodeficiency virus type 1 assembly in murine cells.
Malim Michael H., In PLoS Pathogens, 1999
... Briefly, CD14-positive monocytes were purified from PBMC by magnetic bead separation (Miltenyi Biotec) and cultured in RPMI ...
CD1d-restricted Human Natural Killer T Cells Are Highly Susceptible to Human Immunodeficiency Virus 1 Infection
Unutmaz Derya et al., In The Journal of Experimental Medicine, 1999
These cells were then incubated with anti–HLA-DR and CD14 antibodies (BD Biosciences) followed by Dynabeads conjugated ...
C1q deficiencies and C1q in autoimmunity
Elkon Keith B. et al., In The Journal of Experimental Medicine, 1997
... mAbs to Fas (CH11), CD14, and a polyclonal sheep antiserum to FH were purchased from Upstate Biotechnology, Jackson ImmunoResearch Laboratories, and The Binding Site, respectively ...
Impaired Differentiation of Osteoclasts in TREM-2–deficient Individuals
Colonna Marco et al., In The Journal of Experimental Medicine, 1997
... Monocytes were isolated from PBMCs of Nasu-Hakola patients and healthy controls using anti-CD14 microbeads (Miltenyi Biotec) and cultured in RPMI ...
CD34 positive blood stem cells for allogeneic progenitor and stem cell transplantation
Ulmer Artur J. et al., In The Journal of Experimental Medicine, 1996
... analysis after staining with anti-CD14 (Leu-M3; Becton Dickinson ...
Targeted interleukin-2 therapy for spontaneous neuroblastoma metastases to bone marrow
Lesniak Maciej S., In PLoS ONE, 1996
... (FITC) (BD Biosciences Pharmingen, Franklin Lake, NJ, USA), CD45 FITC (Caltag Laboratories, Burlingame, CA, USA), CD14 phycoerytrin (PE) (BD Biosciences Pharmingen), CD90 PE (BD ...
Immunohistochemical expression of inhibin/activin subunits in epithelial and granulosa cell tumours of the ovary.
Soyer H. Peter, In PLoS ONE, 1996
... monocytes were isolated from buffy coats (Centro Trasfusionale Brescia, Italy) by positive magnetic separation using CD14 immunomagnetic beads (Miltenyi Biotec, Auburn, CA) ...
Costimulation of CD28- T lymphocytes by 4-1BB ligand
Steinberger Peter et al., In Immunology Letters, 1996
... The mAb to CD14 (MEM-18) was purchased from An der Grub (Kaumberg, Austria), CD19 mAb ...
HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5
Maurer Dieter et al., In The Journal of Experimental Medicine, 1995
... PE-conjugated mAbs included anti-CD14 (Becton Dickinson), anti-CD1a and anti-CXCR4 (PharMingen), ...
Hypoxia enhances stimulus-dependent induction of E-selectin on aortic endothelial cells
Ridley Anne J. et al., In The Journal of Cell Biology, 1995
... ); TNF-α (Insight Biotechnology); mouse monoclonal anti-CD45 and anti-CD14 antibodies (Leucogate; Becton Dickinson ...
CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+TNF alpha
Banchereau Jacques et al., In The Journal of Experimental Medicine, 1995
... mAbs: CD2, CD11b, CD14, HLA-DR (Becton Dickinson); CD86 (BD PharMingen); CD9 ...
Characteristics of antigen-independent and antigen-dependent interaction of dendritic cells with CD4+ T cells
de Jong Esther C et al., In Retrovirology, 1994
... Mouse anti-human mAbs were used against the following molecules: CD14 (BD Biosciences), CD1b (Diaclone, Besançon, France), ...
Reciprocal Activating Interaction between Natural Killer Cells and Dendritic Cells
Trinchieri Giorgio et al., In The Journal of Experimental Medicine, 1994
... thawed and depleted of T and B lymphocytes and monocytes by magnetic depletion using FITC–anti-CD3, –anti-CD19, and –anti-CD14 mAb, goat anti-FITC–magnetic microbeads, BS separation columns, and a VarioMACS magnet (Miltenyi Biotec).
Hořejší Václav et al., In The Journal of Experimental Medicine, 1993
... flow cytometer (Becton Dickinson) and PE-conjugated mAbs to CD3 and CD19 (Serotec), biotinylated anti-CD14 (Serotec), fluoresceinylated (FITC) streptavidin (BD Biosciences), unlabeled CD56 mAb MEM-188, ...
Role of leukocyte-derived pro-opiomelanocortin peptides in endotoxic shock
Oppenheim J.J. et al., In The Journal of Experimental Medicine, 1990
... CD14 microbeads (Miltenyi Biotec Inc., Auburn, CA) as ...
A single amino acid in the glycosyl phosphatidylinositol attachment domain determines the membrane topology of FcγRIII
Schreiber Alan D et al., In Immunity & ageing : I & A, 1988
... The pellet was washed twice before 5 μl of phycoerythrin-conjugated anti-CD14 (Becton Dickinson) was added and incubated ...
Functional model of subcomponent C1 of human complement
Ghebrehiwet Berhane et al., In Frontiers in Immunology, 1985
... Antibodies used were against: CD14 (BioLegend, San Diego, CA, USA); ...
Non–T Cell Activation Linker (NTAL)
Hořejší Václav et al., In The Journal of Experimental Medicine, 1980
... FACS Vantage™ flow cytometer (Becton Dickinson) and PE-conjugated mAbs to CD3 and CD19 (Serotec), biotinylated anti-CD14 (Serotec), fluoresceinated streptavidin (BD Biosciences), unlabeled CD56 mAb MEM-188 ...
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