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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Integrin, beta 2

CD11b, CD18, LFA-1, CD11a, Mac-1, Lymphocyte Function-Associated Antigen-1
The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, CD4, HAD, CD8
Papers using CD11b antibodies
Periurethral injection of autologous adipose-derived stem cells with controlled-release nerve growth factor for the treatment of stress urinary incontinence in a rat model
Câmara Niels Olsen Saraiva, In PLoS ONE, 2010
... cells by magnetic cell sorting: cells were incubated with MicroBeads conjugated to monoclonal rat anti-mouse/human CD11b antibody (Miltenyi Biotec GmbH, Bergisch Gladbach, Germany) ...
Assessment of seasonal influenza A virus-specific CD4 T-cell responses to 2009 pandemic H1N1 swine-origin influenza A virus.
Nixon Douglas F., In PLoS ONE, 2009
... Functional grade anti-CD28 and anti-CD11a was purchased from eBioscience (San Diego, CA) and ...
Akt cys-310-targeted inhibition by hydroxylated benzene derivatives is tightly linked to their immunosuppressive effects
Cho Jae Youl et al., In Mediators of Inflammation, 2009
... Antibodies to costimulatory (CD80, CD86, CD40, and CD69) and adhesion (CD29, CD43, and CD18) molecules were from BD Biosciences (San Diego, CA) ...
Estrogen-dependent and C-C chemokine receptor-2-dependent pathways determine osteoclast behavior in osteoporosis
Rameshwar Pranela, In PLoS ONE, 2008
... Unlabeled anti-rat CD11b/c and Alexa Flour 488 mouse anti-rat CD11b/c (OX-42) were obtained from Biolegend (San Diego, CA) ...
Oxidative DNA damage in polymorphonuclear leukocytes of patients with familial Mediterranean fever
Guzik Krzysztof et al., In Journal of Biomedicine and Biotechnology, 2007
... immunofluorescent staining of CD14 (clone: TÜK4, DakoCytomation Denmark A/S, Glostrup, Denmark), CD16 (clone: DJ130c, DakoCytomation), CD11b (clone: ICRF44, Becton Dickinson and Co., Franklin Lakes, ...
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Papers on CD11b
Monocyte Recruitment following High-Intensity and High-Volume Resistance Exercise.
Stout et al., Kennesaw, United States. In Med Sci Sports Exerc, Feb 2016
Tumor necrosis factor receptor-1 (TNFr1), macrophage-1 antigen (CD11b), and C-C chemokine receptor-2 (CCR2) expressions were measured using flow cytometry.
Adeno associated viral-mediated intraosseous labeling of bone marrow derived cells for CNS tracking.
Lee et al., Tampa, United States. In J Immunol Methods, Feb 2016
We also demonstrate that GFP labeled cells correspond to bone marrow cells of myeloid origin using CD11b as a marker.
Targeting peroxiredoxin I potentiates 1,25‑dihydroxyvitamin D3‑induced cell differentiation in leukemia cells.
Hao et al., Shanghai, China. In Mol Med Report, Feb 2016
Cell viability was assessed using a trypan blue exclusion assay and flow cytometry was used to evaluate the expression of cell surface markers, CD11b/CD14, and the level of reactive oxygen species (ROS).
Macrophage-mediated inflammation and glial response in the skeletal muscle of a rat model of familial amyotrophic lateral sclerosis (ALS).
Suzuki et al., Madison, United States. In Exp Neurol, Feb 2016
A significant increase in the expression of microglial inflammatory markers (CD11b and CD68) occurred in the skeletal muscle of symptomatic and end-stage SOD1(G93A) rats.
Group 2 innate lymphoid cells license dendritic cells to potentiate memory TH2 cell responses.
McKenzie et al., Columbia, United States. In Nat Immunol, Jan 2016
ILC2-derived interleukin 13 (IL-13) is critical for eliciting production of the TH2 cell-attracting chemokine CCL17 by IRF4(+)CD11b(+)CD103(-) dendritic cells (DCs).
The many faces of Mac-1 in autoimmune disease.
Mayadas et al., Mexico. In Immunol Rev, Jan 2016
Mac-1 (CD11b/CD18) is a β2 integrin classically regarded as a pro-inflammatory molecule because of its ability to promote phagocyte cytotoxic functions and enhance the function of several effector molecules such as FcγR, uPAR, and CD14.
[Relationship between macrophages and erythropoiesis].
Zhu et al., Tianjin, China. In Zhongguo Dang Dai Er Ke Za Zhi, Jan 2016
A recent mouse study has demonstrated that the phenotype of macrophages in erythroblastic islands is CD169(+) VCAM-1(+) ER-HR3(+) CD11b(+) F4/80(+) Ly-6G(+).
[Significance of PLSCR1 in Matrine Induced Differentiation of ATRA Resistant APL Cells].
Zhou et al., In Zhongguo Zhong Xi Yi Jie He Za Zhi, Nov 2015
Effects of combined treatment of 0.1 mmol/L MAT and 1 [mol/L ATRA on the differentiation of two cell lines were detected using nitroblue tetrazolium (NBT) reduction test and flow cytometry (CD11b).
Mechanisms of LtxA (Leukotoxin), a Potent New Anti-Inflammatory Agent for the Treatment of Alopecia Areata.
Kachlany, Newark, United States. In J Investig Dermatol Symp Proc, Nov 2015
Migration of these activated WBCs from the blood stream and into the follicle tissue requires interaction between the integrin, lymphocyte function-associated antigen-1 (LFA-1) on WBCs, and ICAM-1 on vascular endothelial cells.
Splenic Dendritic Cells Survey Red Blood Cells for Missing Self-CD47 to Trigger Adaptive Immune Responses.
Cyster et al., San Francisco, United States. In Immunity, Nov 2015
DC capture of Cd47(-/-) RBCs and DC activation occurred within minutes in a Src-family-kinase- and CD18-integrin-dependent manner.
PI3-Kinase-γ Has a Distinct and Essential Role in Lung-Specific Dendritic Cell Development.
Kopf et al., Zürich, Switzerland. In Immunity, Nov 2015
Here we show that the Ras-PI3Kγ-Akt-mTOR signaling axis acted downstream of FLT3L signaling and was required for development of lung CD103(+) DCs and, to a smaller extent, for lung CD11b(+) DCs, but not related DC populations in other non-lymphoid organs.
Protein-protein interactions as drug targets.
Ottmann et al., Dortmund, Germany. In Future Med Chem, Oct 2015
Here, we summarize the current state of small-molecule inhibition and stabilization of PPIs and review the active molecules from a structural and medicinal chemistry angle, especially focusing on the key examples of iNOS, LFA-1 and 14-3-3.
Distinct Murine Mucosal Langerhans Cell Subsets Develop from Pre-dendritic Cells and Monocytes.
Hovav et al., Jerusalem, Israel. In Immunity, Sep 2015
Mucosal LCs can be segregated into CD103(+)CD11b(lo) (CD103(+)) and CD11b(+)CD103(-) (CD11b(+)) subsets.
Neutrophils promote Alzheimer's disease-like pathology and cognitive decline via LFA-1 integrin.
Constantin et al., Verona, Italy. In Nat Med, Aug 2015
Aβ42 peptide triggered the LFA-1 integrin high-affinity state and rapid neutrophil adhesion to integrin ligands.
Shishkina et al., In Anesteziol Reanimatol, May 2015
We notified the newest methods in sepsis diagnosis such as plasma amyloid A, DAMP molecules, cell surface markers CD64, CD11b, and inter-a inhibitor proteins.
SDF-1α (CXCL12) regulation of lateral mobility contributes to activation of LFA-1 adhesion.
Kucik et al., Birmingham, United States. In Am J Physiol Cell Physiol, 2012
SDF-1alpha releases LFA-1 from cytoskeleton, correlating with increased LFA-1-mediated adhesion under physiological shear stress.
Thioredoxin reductase linked to cytoskeleton by focal adhesion kinase reverses actin S-nitrosylation and restores neutrophil β(2) integrin function.
Bogush et al., Philadelphia, United States. In J Biol Chem, 2012
Thioredoxin reductase linked to cytoskeleton by focal adhesion kinase reverses actin S-nitrosylation and restores neutrophil beta(2) integrin function.
Integrin αXβ₂ is a leukocyte receptor for Candida albicans and is essential for protection against fungal infections.
Soloviev et al., Cleveland, United States. In J Immunol, 2012
In transgenic mice, integrin alphaXbeta2 is required to control Candida albicans infection; in the brains of mice postinfection, C. albicans forms a visible network of numerous fungal hyphae.
Leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction induces a novel genetic signature resulting in T-cells refractory to transforming growth factor-β signaling.
Kelleher et al., Dublin, Ireland. In J Biol Chem, 2012
suggest an important role for LFA-1/ICAM-1 interactions in immunoregulation concurrent with lymphocyte migration that may have implications at the level of local inflammatory response and for anti-LFA-1-based therapies
Tissue plasminogen activator activates NF-κB through a pathway involving annexin A2/CD11b and integrin-linked kinase.
Hu et al., Penn Hills, United States. In J Am Soc Nephrol, 2012
Tissue plasminogen activator activates the NF-kappaB pathway in macrophages through a signaling pathway involving annexin A2/CD11b-mediated integrin-linked kinase.
More papers using CD11b antibodies
Attenuated translocation of group IVa phospholipase A2 and up-regulated annexin-1 synthesis by glucocorticoid blocks beta 2-integrin adhesion in neutrophils
Zhu Xiangdong et al., In Journal of Inflammation (London, England), 2007
... study include anti-Pyk2, anti-tyrosine 402 phospho-Pyk2 (Cell Signaling, MA), mouse IgG (Southern biotech, UT), and anti-CD18 mAb (7E4, Ancell, MN) ...
Immune interactions in malaria co-infections with other endemic infectious diseases: implications for the development of improved disease interventions
Hänscheid Thomas et al., In Malaria Research and Treatment, 2007
... Fluorescein isothiocyanate (FITC) or phycoerythrin (PE) labelled antibodies against surface antigens (F4/80-PE, GR-1-PE, CD11b-FITC and Fc-block) were purchased from eBioscience (San Diego, CA, USA) ...
Imbalance in distribution of functional autologous regulatory T cells in rheumatoid arthritis
Feldmann Marc et al., In Arthritis Research & Therapy, 2006
... Blocking antibodies against CD18 (clone TS1/18) and CD11a (clone HI111) were from BioLegend (Cambridge, UK), anti-CD69 (clone ...
Activation of the subventricular zone in multiple sclerosis: evidence for early glial progenitors
Rathbone Michel P. et al., In Purinergic Signalling, 2006
... Lab-SA System Kit, San Francisco, CA, USA) and mouse anti-microglial-specific marker OX-42 monoclonal antibodies (1:200; CD11b, Research Diagnostics Inc., Flanders, NJ, USA) ...
Advances in methods for the production, purification, and characterization of HIV-1 Gag-Env pseudovirion vaccines
Pöhlmann Stefan, In PLoS ONE, 2006
... Anti-LFA-1 antibodies MEM25 and MEM83 were from Thermo Scientific (Rockford, IL) ...
MAC1 mediates LPS-induced production of superoxide by microglia: the role of pattern recognition receptors in dopaminergic neurotoxicity
Denning Gerene M et al., In Journal of Inflammation (London, England), 2006
... Blocking antibodies to TLR4 (HTA-125) and to CD11, CD11b, and CD18 were purchased from eBioscience (San Diego, CA) ...
Expression of Tie-2 by human monocytes and their responses to angiopoietin-2.
Harrison Jeffrey K., In PLoS ONE, 2006
... Inhibitor of alpha5beta1 and anti-CD11b-FITC were purchased from Santa Cruz Biotechnology.
Country as the primary risk factor for renal amyloidosis in familial Mediterranean fever.
Ellis Steven R., In PLoS ONE, 2006
... The fluorescein isothiocyanate (FITC)-conjugated antibody recognising the ligand-binding domain of the CD11b-integrin (mouse mAb, CBRM1/5) was from eBioscience.
Tumor necrosis factor inhibitors for rheumatoid arthritis
Roodman G David et al., In Journal of Bone and Mineral Research, 2005
... CD11b microbeads were obtained from Miltenyi Biotec (Gladbach, Germany) ...
Stem cells as a source of regenerative cardiomyocytes
Singer Mervyn, In PLoS Medicine, 2005
... RAM34), VCAM-1 (clone 429[MVCAM.A]), Flk1 (clone Avas 12a1), cKit (clone 2B8), CD45R (clone RA3-6B2), and CD11b (clone M1/70) and corresponding isotype controls purchased from BD Biosciences, and analyzed by flow ...
Overexpression of podoplanin in oral cancer and its association with poor clinical outcome
Sawa Yoshihiko et al., In Acta Histochemica et Cytochemica, 2005
... Mar, CA, USA), rabbit anti-α-smooth muscle actin (monoclonal; Epitomics, Inc., Burlingame, CA, USA), rat anti-mouse CD11b/Mac-1 a chain (monoclonal; BD Biosciences, San Jose, CA, USA), ...
The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity
Behar Samuel M. et al., In The Journal of Experimental Medicine, 2004
... Kuchroo), goat F(ab’)2 anti–human Ig (2012–01; SouthernBiotech), CD11b microbeads (Miltenyi Biotec), CD4 microbeads (Miltenyi Biotec), ...
Neisseria meningitidis infection of human endothelial cells interferes with leukocyte transmigration by preventing the formation of endothelial docking structures
Bourdoulous Sandrine et al., In The Journal of Cell Biology, 2004
... obtained from BD Biosciences, mAb to ICAM-2 (MAB2147) was obtained from Chemicon, and mAb to LFA-1 (sc-7306) was purchased from Santa Cruz Biotechnology, Inc ...
Cell cycle: bistability is needed for robust cycling.
Unutmaz Derya, In PLoS ONE, 2004
... B220 (RA3-6B2), CD19 (ID3), CD21 (7G6), IgM (11/41), Ly6C (AL-21), Ly6G (1A8), Gr-1 (RB6-8C5), and CD11b (M1/70) were kindly provided by BD Biosciences (La Jolla, CA) ...
Macrophage contributions to ovarian functions
Fraser Hamish M et al., In Reproduction (Cambridge, England), 2003
... CD11b-DTR mice are transgenic for the human DTR ...
Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron
Klinge Petra M et al., In Cerebrospinal Fluid Research, 2002
... Aβ40/42 (polyclonal; US BIOLOGICAL), glial fibrillary acidic protein (GFAP polyclonal, DAKO) and the microglial marker CD11b (monoclonal; BIOMOL).
A centrifugation cell adhesion assay for high-throughput screening of biomaterial surfaces.
Kreplak Laurent, In PLoS ONE, 2002
... Rat anti-mouse PE-Sca1, PerCP-CD45, PE-CD29, and APC-CD11b, and red blood cell lysis buffer were purchased from Biolegend.
ADAP–SLP-76 Binding Differentially Regulates Supramolecular Activation Cluster (SMAC) Formation Relative to T Cell–APC Conjugation
Rudd Christopher E. et al., In The Journal of Experimental Medicine, 2002
... Findell, Syntex, Palo Alto, CA); anti-CD3 and anti-CD11a (BD Biosciences); murine ICAM-1 human Fc ...
Vav1 Phosphorylation Is Induced by β2 Integrin Engagement on Natural Killer Cells Upstream of Actin Cytoskeleton and Lipid Raft Reorganization
Long Eric O. et al., In The Journal of Experimental Medicine, 2002
... For cross-linking experiments we used the anti CD11a (BD Biosciences) and F(ab′) ...
Caspase-8 and caspase-10 activate NF-kappaB through RIP, NIK and IKKalpha kinases.
Ratner Adam J., In PLoS ONE, 2002
... The hMDMs phenotype was evaluated by immunofluorescent staining for CD14 (DakoCytomation), CD16 (DakoCytomation), CD11b (Becton Dickinson), and CD209 (Becton Dickinson) ...
Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2
Neumann Harald et al., In The Journal of Experimental Medicine, 2002
... the isolated microglia was >95% as determined by flow cytometry analysis with antibody directed against CD11b (BD Biosciences).
Spatiotemporal regulation of moesin phosphorylation and rear release by Rho and serine/threonine phosphatase during neutrophil migration
Huttenlocher Anna et al., In The Journal of Cell Biology, 2001
... and mouse anti–αvβ3 integrin (clone LM609; Millipore), mouse anti–human CD18 (clone TS1/18), and mouse anti–human Cd11b (clone CBRM1/5; BioLegend).
T cell control of the gut IgA response against commensal bacteria
Ishimura Kazunori et al., In International Journal of Nanomedicine, 2000
... Anti-mouse CD11b (Mac 1 alpha chain) antibody and affinity-purified antimouse DC marker (33D1) were purchased from eBioscience, Inc (Kobe, Japan) ...
Transdifferentiation of polymorphonuclear neutrophils: acquisition of CD83 and other functional characteristics of dendritic cells
Foster Thomas H. et al., In Theranostics, 2000
... using intradermal (ID) administration of 3 μg of anti-mouse Gr1 and CD11b antibodies (Gr1: clone RB6-8C5; CD11b: clone M1/70, Biolegend, San Diego, CA) and ...
Critical role for scaffolding adapter Gab2 in FcγR-mediated phagocytosis
Neel Benjamin G. et al., In The Journal of Cell Biology, 2000
... Purified rat anti–murine CD16/CD32 (mAb 2.4G2), PE-labeled rat anti–murine CD16/CD32, and FITC-labeled anti–murine Mac-1 were obtained from BD Biosciences.
Simultaneous bilateral femoral fractures: systemic complications in 14 cases
Leenen Luke PH et al., In World Journal of Emergency Surgery : WJES, 1999
... Hampshire, United Kingdom), RPE-labeled IgG2a negative control (clone MRC OX-34, Serotec, Dusseldorf, Germany) and RPE-labelled CD11b (clone 2LPM19c, DAKO, Glostrup, Denmark) ...
T cell-derived IL-10 promotes lung cancer growth by suppressing both T cell and APC function.
Sarkar Devanand, In PLoS ONE, 1998
... anti-IFNγ, anti EpCam and anti-CD107a were from eBioscience (San Diego, CA) and anti-Gr1, anti-CD45 and anti-CD11b were from Biolegend (San Diego, CA) ...
HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5
Maurer Dieter et al., In The Journal of Experimental Medicine, 1995
... FITC-conjugated mAbs used were anti-CD1a, anti-CCR5, and anti–B7-2 (PharMingen); anti-CD2 and anti-CD11b (Becton Dickinson); and anti-CD3 (Immunotech) ...
Leishmania promastigotes selectively inhibit interleukin-12 induction in bone marrow-derived macrophages from susceptible and resistant mice
Kelsall Brian L. et al., In The Journal of Experimental Medicine, 1995
... Cell purity was checked by flow cytometry analysis using monoclonal antibodies to CD14 and CD11b (Becton Dickinson ...
Contact-dependent Stimulation and Inhibition of Dendritic Cells by Natural Killer Cells
Valiante Nicholas M. et al., In The Journal of Experimental Medicine, 1995
... anti–human; Biosource International); r-hu-fas-ligand/Fc chimera (CD178; R&D Systems); hu-CTLA-4 muIg fusion protein (CD152; Ancell); anti–LFA-1 (CD11a, mAb G43–25B; Becton Dickinson); anti–TNF-α (mAb B154.2); anti–IL-12 ...
Rapid activation of the STAT3 transcription factor by granulocyte colony-stimulating factor
Nerurkar Pratibha V., In PLoS ONE, 1993
... Phycoerythrin-labeled anti-mouse CD11a/CD18 antibodies and fluorescein isothiocyanate (FITC)-labeled anti-mouse CD11b antibodies were purchased from BioLegend Inc ...
The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance
Stein-Streilein Joan et al., In The Journal of Experimental Medicine, 1991
... Laboratories), PE- and Rhodamine-conjugated anti–mouse B220 Ab, Rhodamine-conjugated anti–mouse CD3 Ab (BD Biosciences), FITC-conjugated anti–mouse Mac-1 Ab (BD Biosciences), PE-conjugated anti–mouse F4/80 Ab ...
Enumeration and characterisation of DJHstructures in mouse fetal liver
Ehlich Andreas et al., In The Journal of Experimental Medicine, 1991
... ) or antibody CD11B (anti–Mac-1; Miltenyi Biotec), and in addition rat ...
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei.
Block Michelle L., In PLoS ONE, 1982
... Mouse anti-rat OX-42 (CD11b) antibody was obtained from AbD Serotec (Oxford, Canterbury, UK) ...
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