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CD1a molecule

CD1, CD1a, CD1d, FKBP12
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, V1a, S-100, MHC
Papers using CD1 antibodies
CASK point mutation regulates protein-protein interactions and NR2b promoter activity
Grabowski Paula J. et al., In Journal of Nucleic Acids, 2008
... One dozen mouse (CD1 strain) embryonic day 18 cerebral cortex tissues (Hilltop Lab Animals, Inc) were dissociated and plated on poly-D-lysine coated 10 cm dishes (BD Biosciences) as described [ ...
Pax3 regulation of FGF signaling affects the progression of embryonic progenitor cells into the myogenic program
Sampaolesi Maurilio et al., In Journal of Biomedicine and Biotechnology, 2007
... hybridization were dissected from CD1 wt (wild-type) female mice mated with homozygous Magic-F1 transgenic male mice (Stem Cell ...
Preconditioning enhances cell survival and differentiation of stem cells during transplantation in infarcted myocardium
Toietta Gabriele et al., In Stem Cells International, 2007
... Mice used in the study were 6- to 8-week-old wild-type Swiss CD1 males, transgenic mice expressing ubiquitously GFP ...
Quantifying the role of aberrant somatic hypermutation in transformation of follicular lymphoma
Delabie Jan et al., In Journal of Hematopathology, 2007
... CD1a (MTB1)Novocastra™1:5T/EPU1 (polyclonal)Santa Cruz Biotechnology ...
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Papers on CD1
Immune sensing of microbial glycolipids and related conjugates by T cells and the pattern recognition receptors MCL and Mincle.
Williams et al., Melbourne, Australia. In Carbohydr Res, Feb 2016
The antigen-presenting molecules of the CD1 class, CD1a-d, capture lipidic molecules and present them to diverse and innate-like T cell populations including natural killer T cells and germline-encoded mycolyl reactive T cells.
Control of B cell lymphoma by therapeutic vaccination and acquisition of immune resistance is independent of direct tumor IFN-gamma signaling.
Mattarollo et al., Brisbane, Australia. In Immunol Cell Biol, Feb 2016
With successive exposure to vaccination, lymphomas acquired an increasingly therapy-resistant phenotype and displayed a reduction in MHCI and CD1d surface expression, which is independent of tumor intrinsic IFNγ-signalling.
miR-322 regulates insulin signaling pathway and protects against metabolic syndrome-induced cardiac dysfunction in mice.
Lompré et al., Paris, France. In Biochim Biophys Acta, Feb 2016
This cardioprotection could be associated with the regulation of identified targets IGF1R, INSR and CD1, a decrease in insulin signaling pathway and an enrichment of genes involved in mitochondrial function and fatty acid oxidation as demonstrated by transcriptome analysis.
Brief review of the chicken Major Histocompatibility Complex: the genes, their distribution on chromosome 16, and their contributions to disease resistance.
Taylor et al., Duarte, United States. In Poult Sci, Feb 2016
Nearby MHC-B is a small region containing two CD1 genes, which encode molecules known to bind lipid antigens and which will likely be found in chickens to present lipids to specialized T cells, as occurs with CD1 molecules in other species.
Natural Killer T cell subsets in eutopic and ectopic endometrium: a fresh look to a busy corner.
Sofo et al., Messina, Italy. In Arch Gynecol Obstet, Feb 2016
PURPOSE: Invariant Natural Killer T cells (iNKT) are a specialized subset of T cells that use their T cell receptor to recognize self and foreign lipids presented by CD1d as cognate antigens.
IL-30 (IL27p28) alleviates sepsis via modulation of cytokine profiles produced by NKT cells.
Li et al., Houston, United States. In J Hepatol, Feb 2016
The inhibitory effects of IL-30 on septic inflammation and associated therapeutic effects were determined in wild-type, IL-30 (p28)(-/-), IL10(-/-), and CD1d(-/-) mice.
Histiocytic differentiation in acute monocytic leukemia.
Wang et al., Tianjin, China. In Ultrastruct Pathol, Jan 2016
To clarify the conception, 93 M5 cases were tested with antibodies for HRAs, CD1a, CD163, S100, fascin, and langerin by immunostaining, and their morphologic characteristics were studied by light and transmission electron microscopy.
Isolated Intramedullary Spinal Rosai-Dorfman Disease: A Case Report and Literature Review.
Yu et al., Beijing, China. In World Neurosurg, Jan 2016
Histopathological examination showed a characteristic emperipolesis, the lymphocytes were engulfed in the S-100-protein-positive histiocytes with negative expression of CD1a.
Solitary langerhans cell histiocytosis in an adult: case report and literature review.
Mendonça et al., Palmas, Brazil. In Bmc Res Notes, Dec 2015
An immunohistochemical staining panel was done to determine the nature of this inflammatory infiltrate by using antibodies S-100, CD1a, CD-68 and CD45RO that were positive.
Correlation analyses between pre- and post-operative adverse events in gastric cancer patients receiving preoperative treatment and gastrectomy.
Noh et al., Seoul, South Korea. In Bmc Cancer, Dec 2015
Correlations between CTCAE grades and CD grades were analyzed, and clinical data and laboratory findings were compared among three groups classified according to CD grades: CD0, CD1/2, and CD3/4.
The burgeoning family of unconventional T cells.
Moody et al., Melbourne, Australia. In Nat Immunol, Nov 2015
These include CD1-restricted T cells, MR1-restricted mucosal associated invariant T cells (MAIT cells), MHC class Ib-reactive T cells, and γδ T cells.
Lipid and small-molecule display by CD1 and MR1.
Moody et al., Boston, United States. In Nat Rev Immunol, Oct 2015
The use of tetramers of human CD1a, CD1b, CD1c or MR1 proteins now allows detailed analysis of the human T cell repertoire, which has revealed new invariant TCRs that bind CD1b molecules and are different from those that define natural killer T cells and mucosal-associated invariant T cells.
Inflammation-induced formation of fat-associated lymphoid clusters.
Caamaño et al., Berlin, Germany. In Nat Immunol, Aug 2015
Natural killer T cells (NKT cells) restricted by the antigen-presenting molecule CD1d were likewise required for the inducible formation of FALCs.
DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation.
Bradner et al., Boston, United States. In Science, Jul 2015
A second series of probes resulted in selective degradation of the cytosolic protein FKBP12.
The effect of trauma on invasive group A streptococcal disease.
Sriskandan et al., Didcot, United Kingdom. In Lancet, Mar 2015
METHODS: A new model of mild contusion was developed using a weight drop device and characterised in two strains of mice, CD1 and FVB/n.
Deciphering the role of CD1e protein in mycobacterial phosphatidyl-myo-inositol mannosides (PIM) processing for presentation by CD1b to T lymphocytes.
Gilleron et al., Toulouse, France. In J Biol Chem, 2012
Deciphering the role of CD1e protein in mycobacterial phosphatidyl-myo-inositol mannosides (PIM) processing for presentation by CD1b to T lymphocytes
Levels of gemcitabine transport and metabolism proteins predict survival times of patients treated with gemcitabine for pancreatic adenocarcinoma.
Van Laethem et al., Brussels, Belgium. In Gastroenterology, 2012
RRM1 levels in pancreatic ductal adenocarcinoma did not predict survival times in patients treated with adjuvant gemcitabine.
Alteration of CD1 expression in multiple sclerosis.
Gelin et al., Paris, France. In Clin Exp Immunol, 2012
these results reveal that CD1 expression is modified in MS and provide novel information on the regulation of lipid antigen presentation in myeloid cells.
Impact of hypoxia, simulated ischemia and reperfusion in HL-1 cells on the expression of FKBP12/FKBP12.6 and intracellular calcium dynamics.
Grip et al., Göteborg, Sweden. In Biochem Biophys Res Commun, 2012
the impact of simulated ischemia and reperfusion on expression of the calcium handling proteins FKBP12 and FKBP12.6, and intracellular calcium dynamics was investigated.
CD1d expression on and regulation of murine hematopoietic stem and progenitor cells.
Brutkiewicz et al., Indianapolis, United States. In Blood, 2012
The results of the present study implicate CD1d in a previously unrecognized regulatory role of normal and stressed hematopoiesis.
More papers using CD1 antibodies
Follicular dendritic cell sarcoma in the lymph nodes of the neck
Adam Patrick et al., In Diagnostic Pathology, 2006
... CD1aDAKO ...
Activated AKT regulates NF-κB activation, p53 inhibition and cell survival in HTLV-1-transformed cells
Simmet Thomas et al., In Journal of Biomedicine and Biotechnology, 2004
... p65-Santa Cruz Biotechnology (Santa Cruz, CA); actin-Chemicon International (Chemicon, Temecula, CA); HLA-DR, CD80, CD86, and CD1a-BD Biosciences (Heidelberg, Germany); S100 [ ...
Regulation of phagosome maturation by signals from toll-like receptors.
Rodrigues Mauricio Martins, In PLoS ONE, 2003
... Miltenyi Biotech (Bergisch Gladbach, Germany), αvβ3 (LM609) and αvβ5 (P1F6) from Chemicon International (Temecula CA), CD1d (CD1d42) from Becton Dickinson, DC-SIGN (120507) from (R&D ...
Transgenic overexpression of hepatocyte growth factor in the beta-cell markedly improves islet function and islet transplant outcomes in mice.
Maedler Kathrin, In PLoS ONE, 2000
... Our Transgenic mouse model were generated on a pure CD1 background by cross breeding two transgenic lines of mice: one ...
Bone marrow NK1.1(−) and NK1.1(+) T cells reciprocally regulate acute graft versus host disease
Stein-Streilein Joan et al., In The Journal of Experimental Medicine, 1998
... CD1 KO mice were generated in the Transgenic Facility, Harvard Medical School, ...
CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+TNF alpha
Banchereau Jacques et al., In The Journal of Experimental Medicine, 1995
... (Becton Dickinson); CD86 (BD PharMingen); CD9 (Ancell), CD32, CD36 (Caltag), CD40, HLA-ABC, CCR6 (R&D Systems), CD1a (Dako), CD80, CD83, E-Cadherin, and ...
Spatial and temporal patterns of distribution of the gap junction protein connexin43 during mouse gastrulation and organogenesis
Lo C.W. et al., In The Journal of Cell Biology, 1991
... ), breeding of hemizygous FC males with nontransgenic CD1 females provided hemizygous transgenic and wild-type nontransgenic control ...
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