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Chaperonin containing TCP1, subunit 6B

Cctz-2, CCTzeta-2, TSA303
This gene encodes a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010] (from NCBI)
Top mentioned proteins: TRIC, Ccth, CCTG, CCT2, CCT5
Papers on Cctz-2
PhLP3 modulates CCT-mediated actin and tubulin folding via ternary complexes with substrates.
Leroux et al., Canada. In J Biol Chem, 2006
antagonistic actions of PhLP3 and prefoldin serve to modulate CCT activity and play a key role in establishing a functional cytoskeleton in vivo
Structures and co-regulated expression of the genes encoding mouse cytosolic chaperonin CCT subunits.
Yura et al., Kyoto, Japan. In Eur J Biochem, 1999
We have cloned seven CCT subunit genes, Cctb, Cctd, Ccte, Cctz-1, Cctz-2 (testis specific), Ccth and Cctq, from mouse genomic DNA libraries, in addition to the Ccta and Cctg genes reported previously, and the entire nucleotide sequences of these DNA clones were determined.
Tissue-specific subunit of the mouse cytosolic chaperonin-containing TCP-1.
Willison et al., London, United Kingdom. In Febs Lett, 1997
Describes the cloning of a very similar protein in mouse.
Isolation of three testis-specific genes (TSA303, TSA806, TSA903) by a differential mRNA display method.
Nakamura et al., Tokyo, Japan. In Genomics, 1996
The first of these genes, designated TSA303, encodes a novel protein homologous to TCP20, one of the subunits of the human TRiC chaperonin complex that can bind newly synthesized or unstable folding intermediates of polypeptides and assist substrate proteins in folding, assembly, and transport.
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