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Chaperonin containing TCP1, subunit 3

CCTG, CCT3, CCT gamma
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants have been characterized for this gene. In addition, a pseudogene of this gene has been found on chromosome 8. [provided by RefSeq, Aug 2010] (from NCBI)
Top mentioned proteins: DM2, CAN, EXP, TRIC, HAD
Papers on CCTG
Computerized analysis of fetal heart rate variability signal during the stages of labor.
Campanile et al., Napoli, Italy. In J Obstet Gynaecol Res, Feb 2016
AIM: To analyze computerized cardiotocographic (cCTG) parameters (baseline fetal heart rate, baseline FHR; short term variability, STV; approximate entropy, ApEn; low frequency, LF; movement frequency, MF; high frequency, HF) in physiological pregnancy in order to correlate them with the stages of labor.
Molecular chaperone CCT3 supports proper mitotic progression and cell proliferation in hepatocellular carcinoma cells.
Yu et al., Shanghai, China. In Cancer Lett, Jan 2016
UNASSIGNED: CCT3 was one of the subunits of molecular chaperone CCT/TRiC complex, which plays a central role in maintaining cellular proteostasis.
Integrated analysis of gene expression and genomic aberration data in osteosarcoma (OS).
Wang et al., Chongqing, China. In Cancer Gene Ther, Nov 2015
Comparing genomic aberrations and DGEs, we found 41 SNP-associated DEGs and 124 CNV-associated DEGs, in which 7 DGEs were associated with both SNPs and CNVs, including WWP1, EXT1, LDHB, C8orf59, PLEKHA5, CCT3 and VWF.
Optimization PCR for Detection CTG/CCTG-Repeat Expansions in the Diagnosis of Myotonic Dystrophies.
Hu et al., Shijiazhuang, China. In Ann Clin Lab Sci, Sep 2015
CONTEXT: Myotonic dystrophies (DMs) are a group of autosomal dominant neuromuscular disorders which are caused by large CTG/CCTG-repeat expansions in untranslated regions of DMPK/ZNF9 gene.
Overexpression of chaperonin containing TCP1, subunit 3 predicts poor prognosis in hepatocellular carcinoma.
Zhu et al., Beijing, China. In World J Gastroenterol, Aug 2015
AIM: To investigate the value of chaperonin containing TCP1, subunit 3 (CCT3) to predict the prognosis of patients with hepatocellular carcinoma (HCC) and determine its function in HCC progression.
Myotonic dystrophy 2 manifesting with non-alcoholic and non-hepatitic liver cirrhosis.
Gencik et al., In Acta Clin Belg, Aug 2015
His 69-year-old sister, who carried a CCTG expansion of >300 in intron 1 of the CNBP/ZNF9 gene, also manifested in the liver with hyperbilirubinaemia, hepatopathy and hyperlipidaemia since age 48 years.
Myotonic dystrophies: An update on clinical aspects, genetic, pathology, and molecular pathomechanisms.
Cardani et al., San Donato Milanese, Italy. In Biochim Biophys Acta, Apr 2015
Myotonic dystrophy type 1 (DM1, Steinert's disease) is caused by a (CTG)n expansion in DMPK, while myotonic dystrophy type 2 (DM2) is caused by a (CCTG)n expansion in ZNF9/CNBP.
[Myotonic dystrophies: clinical presentation, pathogenesis, diagnostics and therapy].
Rudnik-Schöneborn et al., Aachen, Germany. In Fortschr Neurol Psychiatr, 2015
DM2 is caused by a CCTG-repeat expansion to 75 - 11 000 repeats in intron-1 of the CNBP/ZNF9 gene.
Effect of CYP2B6 Gene Polymorphisms on Efavirenz Plasma Concentrations in Chinese Patients with HIV Infection.
Cai et al., Shanghai, China. In Plos One, 2014
The frequencies of the five haplotypes (high to low) were as follows: CCTG (0.328), ACTG (0.280), ACCT (0.189), ATTG (0.186) and ACCG (0.017).
Therapeutic Approaches for Dominant Muscle Diseases: Highlight on Myotonic Dystrophy.
Chuah et al., Paris, France. In Curr Gene Ther, 2014
The most common DM1 is caused by expanded CTG repeats in the 3'UTR of the DMPK gene, whereas DM2 is due to large expanded CCTG repeats in the first intron of the CNBP gene.
Muscle wasting in myotonic dystrophies: a model of premature aging.
López de Munain et al., San Sebastián, Spain. In Front Aging Neurosci, 2014
The underlying molecular disorder in DM1 consists of the existence of a pathological (CTG) triplet expansion in the 3' untranslated region (UTR) of the Dystrophia Myotonica Protein Kinase (DMPK) gene, whereas (CCTG)n repeats in the first intron of the Cellular Nucleic acid Binding Protein/Zinc Finger Protein 9 (CNBP/ZNF9) gene cause DM2.
Clinical aspects, molecular pathomechanisms and management of myotonic dystrophies.
Meola, Milano, Italy. In Acta Myol, 2013
Myotonic dystrophy type 1 (DM1, Steinert's disease) was described more than 100 years ago and is caused by a (CTG)n expansion in DMPK, while myotonic dystrophy type 2 (DM2) was identified only 18 years ago and is caused by a (CCTG)n expansion in ZNF9/CNBP.
The myotonic dystrophies: molecular, clinical, and therapeutic challenges.
Krahe et al., Tampere, Finland. In Lancet Neurol, 2012
In patients with myotonic dystrophy type 1, a (CTG)(n) expansion is present in DMPK, whereas in patients with type 2 disease, there is a (CCTG)(n) expansion in CNBP.
Proteomic identification of chaperonin-containing tail-less complex polypeptide-1 gamma subunit as a p53-responsive protein in colon cancer cells.
Chan et al., Singapore, Singapore. In Cancer Genomics Proteomics, 2012
Our results implicate a novel cell signaling loop in HCt116 cells involving p53 and TCP1-gamma phosphorylation, which may be related to regulation and action of centrosomes.
Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.
Turck et al., São Paulo, Brazil. In Eur Arch Psychiatry Clin Neurosci, 2009
Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia.
Quantitative actin folding reactions using yeast CCT purified via an internal tag in the CCT3/gamma subunit.
Willison et al., London, United Kingdom. In J Mol Biol, 2006
The results from this controlled CCT-actin folding assay are consistent with a model where CCT and Ac(I) are in a binding pre-equilibrium with a rate-limiting binding step, followed by a faster ATP-driven processing to native actin.
RNA-mediated neuromuscular disorders.
Cooper et al., Minneapolis, United States. In Annu Rev Neurosci, 2005
The identification and characterization of RNA-binding proteins that interact with expanded CUG repeats and the discovery that a similar transcribed but untranslated CCTG expansion in an intron causes myotonic dystrophy type 2 (DM2) have uncovered a new type of mechanism in which microsatellite expansion mutations cause disease through an RNA gain-of-function mechanism.
Identification of chaperonin CCT gamma subunit as a determinant of retinotectal development by whole-genome subtraction cloning from zebrafish no tectal neuron mutant.
Mishina et al., Tokyo, Japan. In Development, 2004
These results suggest that the gamma subunit of chaperonin CCT plays an essential role in retinotectal development.
Positional mapping for amplified DNA sequences on 1q21-q22 in hepatocellular carcinoma indicates candidate genes over-expression.
Johnson et al., Hong Kong, Hong Kong. In J Hepatol, 2003
Among ten hepatocellular carcinoma cases with amplicon 1q21-q22, significant gene expression level of JTB, SHC1, CCT3 and COPA in the tumors than the paired adjacent non-malignant liver tissues.
Myotonic dystrophy type 2 caused by a CCTG expansion in intron 1 of ZNF9.
Ranum et al., Minneapolis, United States. In Science, 2001
We now report that DM2 is caused by a CCTG expansion (mean approximately 5000 repeats) located in intron 1 of the zinc finger protein 9 (ZNF9) gene.
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