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Chaperonin containing TCP1, subunit 5

CCT5, CCTepsilon, Ccte
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. In addition, three pseudogenes of this gene have been identified. [provided by RefSeq, Jun 2010] (from NCBI)
Top mentioned proteins: TRIC, Actin, CCT2, CCT4, CCT8
Papers on CCT5
Identification of the T-complex protein as a binding partner for newly synthesized cytoplasmic dynein intermediate chain 2.
Catling et al., New Orleans, United States. In Biochem Biophys Res Commun, Feb 2016
We confirmed interactions between IC-2 and CCT5 and CCT8 in co-immunoprecipitation experiments and determined that the C-terminal half of IC-2 is necessary and sufficient to bind CCT8.
The molecular chaperone CCT modulates the activity of the actin filament severing and capping protein gelsolin in vitro.
Grantham et al., Göteborg, Sweden. In Cell Stress Chaperones, Jan 2016
Some individual subunits of CCT, when monomeric, have been shown to be functionally active, and in particular, the CCTepsilon subunit is involved in the serum response factor pathway that controls actin transcription.
Structural Mechanisms of Mutant Huntingtin Aggregation Suppression by the Synthetic Chaperonin-like CCT5 Complex Explained by Cryoelectron Tomography.
Chiu et al., Houston, United States. In J Biol Chem, Aug 2015
Specifically, the purified CCT5 homo-oligomer complex, when compared with TRiC, has a similar structure, ATP use, and substrate refolding activity, and, importantly, it also inhibits mHTT aggregation.
Redox proteomics identification of specifically carbonylated proteins in the hippocampi of triple transgenic Alzheimer's disease mice at its earliest pathological stage.
Ni et al., Shenzhen, China. In J Proteomics, Jul 2015
For the first time, the oxidation of t-complex protein 1 subunit epsilon (CCT5) and protein disulfide-isomerase A3 (PDIA3) were reported to be associated with AD.
Comparative proteome analysis of human testis from newborn, young adult, and aged men identified spermatogenesis-associated proteins.
Wang et al., Yantai, China. In Electrophoresis, Jul 2015
Among these, vimentin and CCT5 located in the Sertoli cell may be related to germ cell maturation.
Autoantibodies against protein disulfide isomerase ER-60 are a diagnostic marker for low-grade testicular inflammation.
Meinhardt et al., Marburg an der Lahn, Germany. In Hum Reprod, 2014
Of these 14 proteins, disulfide isomerase family A, member 3 (ER-60), transferrin and chaperonin containing TCP1 complex, subunit 5 (epsilon) (CCT5) were considered as specific.
Biochemical characterization of mutants in chaperonin proteins CCT4 and CCT5 associated with hereditary sensory neuropathy.
King et al., Cambridge, United States. In J Biol Chem, 2014
C450Y CCT4 was identified in a stock of Sprague-Dawley rats, whereas H147R CCT5 was found in a human Moroccan family.
Modulation of proteome expression by F-type lectin during viral hemorrhagic septicemia virus infection in fathead minnow cells.
Kim et al., Kwangju, South Korea. In Fish Shellfish Immunol, 2014
The results suggest RbFTL-3 modulates the expression of proteins related to viral budding (SNF8, CCT5 and TUBB) and thrombin signaling (F2) to increase the viability of VHSV infected cells.
Antibody-validated proteins in inflamed islets of fulminant type 1 diabetes profiled by laser-capture microdissection followed by mass spectrometry.
Kobayashi et al., Japan. In Plos One, 2013
The anti-apoptotic protein T-complex protein 1 subunit epsilon (CCT5), the anti-oxidative enzyme 6-phosphogluconate dehydrogenase (PDG), and the anti-viral and anti-apoptotic proteins serpin B6 (SERPINB6) and heat shock 70 kDa protein1-like (HSPA1L), were identified in FT1DM-affected islet cells.
A human CCT5 gene mutation causing distal neuropathy impairs hexadecamer assembly in an archaeal model.
Robb et al., Baltimore, United States. In Sci Rep, 2013
The human CCT has eight non-identical subunits and the His147Arg mutation in one subunit, CCT5, causes neuropathy.
Human CCT4 and CCT5 chaperonin subunits expressed in Escherichia coli form biologically active homo-oligomers.
King et al., Cambridge, United States. In J Biol Chem, 2013
CCT4 and CCT5, but not the other six CCT subunits, formed high molecular weight complexes within the E. coli cells that sedimented about 20S in sucrose gradients.
Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region.
van Meurs et al., Rotterdam, Netherlands. In Ann Rheum Dis, 2013
located upstream of chaperonin-containing-TCP1-complex-5 gene (CCT5) and downstream of FAM173B, was found to be associated with a 30% higher risk of CWP (minor allele frequency=43%; OR=1.30, 95% CI 1.19 to 1.42, p=1.2×10(-8)).
A novel function of the human chaperonin CCT epsilon subunit in yeast.
Kimura et al., Iizuka, Japan. In Biosci Biotechnol Biochem, 2011
introduction of the truncated human CCT epsilon subunit into yeast cells
Genetic association with overall survival of taxane-treated lung cancer patients - a genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study.
Wang et al., Rochester, United States. In Bmc Cancer, 2011
Knockdown of PIP4K2A, CCT5, CMBL, EXO1, KMO and OPN3, genes within 200 kb up-/downstream of the 3 SNPs that were associated with SCLC overall survival (rs1778335, rs2662411 and rs7519667), significantly desensitized H196 to paclitaxel.
Possible involvement of CCT5, RGS3, and YKT6 genes up-regulated in p53-mutated tumors in resistance to docetaxel in human breast cancers.
Noguchi et al., Suita, Japan. In Breast Cancer Res Treat, 2007
mRNA expression of CCT5, RGS3, and YKT6 was significantly up-regulated in p53-mutated tumors and associated with a low response rate to docetaxel.
Mutation in the epsilon subunit of the cytosolic chaperonin-containing t-complex peptide-1 (Cct5) gene causes autosomal recessive mutilating sensory neuropathy with spastic paraplegia.
Yahyaoui et al., Rabat, Morocco. In J Med Genet, 2006
A missense mutation within the CCT5 gene is associated with autosomal recessive mutilating sensory neuropathy with spastic paraplegia.
Eukaryotic type II chaperonin CCT interacts with actin through specific subunits.
Valpuesta et al., Madrid, Spain. In Nature, 2000
Immunolabelling of CCT-substrate complexes with antibodies against two specific CCT subunits showed that actin binds to CCT using two specific and distinct interactions: the small domain of actin binds to CCTdelta and the large domain to CCTbeta or CCTepsilon (both in position 1,4 with respect to delta).
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