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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Cyclin Y

CCNY, Cyclin Y, cyclin fold protein 1
Cyclins, such as CCNY, control cell division cycles and regulate cyclin-dependent kinases (e.g., CDC2; MIM 116940) (Li et al., 2009 [PubMed 18060517]).[supplied by OMIM, May 2009] (from NCBI)
Top mentioned proteins: PCNA, HAD, LRP6, fibrillin-1, PCTAIRE-1
Papers on CCNY
CDK14 Contributes to Reactive Gliosis via Interaction with Cyclin Y in Rat Model of Spinal Cord Injury.
Shen et al., Nantong, China. In J Mol Neurosci, Dec 2015
cyclin Y, which can interact with CDK14, was detected that had same expression trend was consistent with CDK14 Western blot results in SCI.
Post-transcriptional Wnt Signaling Governs Epididymal Sperm Maturation.
Niehrs et al., Heidelberg, Germany. In Cell, Dec 2015
Here, we show that transcriptionally silent spermatozoa respond to Wnt signals released from the epididymis and that mice mutant for the Wnt regulator Cyclin Y-like 1 are male sterile due to immotile and malformed spermatozoa.
Cyclin Y phosphorylation- and 14-3-3-binding-dependent activation of PCTAIRE-1/CDK16.
Sakamoto et al., Lausanne, Switzerland. In Biochem J, Sep 2015
Cyclin Y has recently been identified as a key interacting/activating cyclin for PCTAIRE-1; however, the molecular mechanism by which it activates PCTAIRE-1 is undefined.
CCNYL1, but Not CCNY, Cooperates with CDK16 to Regulate Spermatogenesis in Mouse.
Wu et al., Hefei, China. In Plos Genet, Aug 2015
Cyclin Y-like 1 (Ccnyl1) is a newly-identified member of the cyclin family and is highly similar in protein sequences to Cyclin Y (Ccny).
Cyclin Y inhibits plasticity-induced AMPA receptor exocytosis and LTP.
Park et al., Seoul, South Korea. In Sci Rep, 2014
Cyclin Y (CCNY) is a member of the cyclin protein family, known to regulate cell division in proliferating cells.
Genetic polymorphism in ATG16L1 gene influences the response to adalimumab in Crohn's disease patients.
Potočnik et al., Maribor, Slovenia. In Pharmacogenomics, 2014
Additional SNPs in 7 out of 31 tested CD-associated genes (PTGER4, CASP9, IL27, C11orf30, CCNY, IL13, NR1I2) showed suggestive association with ADA response.
Cyclin Y Is Involved in the Regulation of Adipogenesis and Lipid Production.
Wu et al., Shanghai, China. In Plos One, 2014
A new member of the cyclin family cyclin Y (CCNY) is involved in the regulation of various physiological processes.
Tumor cell characterization and classification based on cellular specific membrane capacitance and cytoplasm conductivity.
Chen et al., Key West, United States. In Biosens Bioelectron, 2014
μF/cm(2)) was observed for 95D cells (ncell=537) and 95D CCNY-KD cells with single oncogene CCNY down regulation (ncell=479, CCNY is a membrane-associated protein).
PFTK1 interacts with cyclin Y to activate non-canonical Wnt signaling in hepatocellular carcinoma.
Wong et al., Hong Kong, Hong Kong. In Biochem Biophys Res Commun, 2014
To understand the modulated pathway underlining the PFTK1 action, here we show a physical interaction between PFTK1 and cyclin Y (CCNY) in promoting noncanonical Wnt signaling.
Phosphorylation of cyclin Y by CDK14 induces its ubiquitination and degradation.
Chen et al., Shanghai, China. In Febs Lett, 2014
Here we report that human cyclin Y (CCNY) is a phosphoprotein in vivo and that phosphorylation of CCNY by CDK14 triggers its ubiquitination and degradation.
14-3-3 Binding to Cyclin Y contributes to cyclin Y/CDK14 association.
Chen et al., Shanghai, China. In Acta Biochim Biophys Sin (shanghai), 2014
To search for Cyclin Y-interacting proteins, we screened a yeast two-hybrid library using human Cyclin Y (CCNY) as a bait and identified the following interactors: CDK14 and four members of the 14-3-3 family (ε, β, η, τ).
[The function and molecular mechnism of cyclin Y protein].
Yue et al., Beijing, China. In Zhongguo Fei Ai Za Zhi, 2013
Abstract available from the publisher.
[Influence on cell proliferation by small interfering RNA of Cyclin Y expression in laryngeal cancer cells].
Ni et al., Beijing, China. In Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, 2013
OBJECTIVE: The effects of lentivirus-mediated suppression of Cyclin Y (CCNY) expression on the proliferation of laryngeal cancer cells were investigated in vitro.
Orphan kinases turn eccentric: a new class of cyclin Y-activated, membrane-targeted CDKs.
Geley et al., Innsbruck, Austria. In Cell Cycle, 2012
PCTAIREs are activated by cyclin Y (CCNY), a highly conserved single cyclin fold protein.
Cyclin-dependent kinase 16/PCTAIRE kinase 1 is activated by cyclin Y and is essential for spermatogenesis.
Geley et al., Innsbruck, Austria. In Mol Cell Biol, 2012
CCNY binding to CDK16 required a region upstream of the kinase domain and was found to be inhibited by phosphorylation of serine 153, a potential PKA phosphorylation site.
Cell cycle protein cyclin Y is associated with human non-small-cell lung cancer proliferation and tumorigenesis.
Yang et al., Tongzhou, China. In Clin Lung Cancer, 2011
these results validated the role of CCNY as a clinically relevant human oncoprotein
Emerging links between CDK cell cycle regulators and Wnt signaling.
Niehrs et al., Eggenstein-Leopoldshafen, Germany. In Trends Cell Biol, 2010
This concept has now been substantially strengthened with the finding that the mitotic CDK14/cyclin Y complex promotes Wnt signaling through phosphorylation of the LRP6 co-receptor, a key regulatory nexus in the Wnt/beta-catenin pathway.
Lentivirus-mediated knockdown of cyclin Y (CCNY) inhibits glioma cell proliferation.
Yue et al., Harbin, China. In Oncol Res, 2009
CCNY might play an important role in glioma tumorigenisis.
Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis.
Schreiber et al., Kiel, Germany. In Nat Genet, 2008
Single nucleotide polymorphism in CCNY gene is associated with Crohn's disease and ulcerative colitis
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