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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Family with sequence similarity 175, member A

Top mentioned proteins: Iris, RAP80, Nba1, Ubiquitin, RNF8
Papers on CCDC98
Aberrant DNA methylation status of DNA repair genes in breast cancer treated with neoadjuvant chemotherapy.
Ohta et al., Kawasaki, Japan. In Genes Cells, 2013
The aberrant DNA methylation status of the following HR related-genes was analyzed using bisulfite-pyrosequencing: BRCA1, BRCA2, BARD1, MDC1, RNF8, RNF168, UBC13, ABRA1, PALB2, RAD50, RAD51, RAD51C, MRE11, NBS1, CtIP and ATM.
BRCA1 and Its Network of Interacting Partners.
Kyriacou et al., Nicosia, Cyprus. In Biology (basel), 2012
BRCA1 interactions with the MRN complex of proteins, with the BRCC complex of proteins that exhibit E3 ligase activity and with the phosphor proteins CtIP, BACH1 (BRIP1) and Abraxas (CCDC98) are also implicated in DNA repair mechanisms and cell cycle checkpoint control.
Structural and functional implication of RAP80 ΔGlu81 mutation.
Varma et al., Mumbai, India. In Plos One, 2012
Receptor Associated Protein 80 (RAP80) is a member of RAP80-BRCA1-CCDC98 complex family and helps in its recruitment to the DNA damage site for effective homologous recombination repair.
The in vivo dynamic organization of BRCA1-A complex proteins at DNA damage-induced nuclear foci.
Henderson et al., Sydney, Australia. In Traffic, 2012
In the mobile fraction, Abraxas (CCDC98) and the heterodimer BARD1-BRCA1 share similar rates of dynamic exchange (complete turnover in ∼500 seconds).
Three-dimensional imaging reveals the spatial separation of γH2AX-MDC1-53BP1 and RNF8-RNF168-BRCA1-A complexes at ionizing radiation-induced foci.
Henderson et al., Sydney, Australia. In Radiother Oncol, 2012
MATERIALS AND METHODS: MCF-7 cells were treated with IR, stained for γH2AX, MDC1, RNF8, RNF168, 53BP1, Abraxas (CCDC98), BRCA1, BRCC36, Merit40 (NBA1) and RAP80, and then imaged using high-resolution three-dimensional (3-D) confocal microscopy to assess the relative localization of proteins at foci.
Breast cancer-associated Abraxas mutation disrupts nuclear localization and DNA damage response functions.
Winqvist et al., Oulu, Finland. In Sci Transl Med, 2012
The recurrent Abraxas c.1082G>A mutation connects to breast cancer predisposition.
Loss of BRCA1-A complex function in RAP80 null tumor cells.
Yu et al., Ann Arbor, United States. In Plos One, 2011
In these cells, not only is the BRCA1-A complex disrupted, but the relocation of the remaining subunits in the BRCA1-A complex including BRCA1, CCDC98, NBA1, BRCC36 and BRE is significantly suppressed.
Tubulin, BRCA1, ERCC1, Abraxas, RAP80 mRNA expression, p53/p21 immunohistochemistry and clinical outcome in patients with advanced non small-cell lung cancer receiving first-line platinum-gemcitabine chemotherapy.
Schellens et al., Amsterdam, Netherlands. In Lung Cancer, 2011
low expression correlates with better response to chemotherapy and longer survival in patients with advanced non small-cell lung cancer
Modification of BRCA1-Associated Breast and Ovarian Cancer Risk by BRCA1-Interacting Genes.
Nathanson et al., Philadelphia, United States. In Cancer Res, 2011
A cohort of 2,825 BRCA1 mutation carriers was used to evaluate the association of haplotypes at ATM, BRCC36, BRCC45 (BRE), BRIP1 (BACH1/FANCJ), CTIP, ABRA1 (FAM175A), MERIT40, MRE11A, NBS1, PALB2 (FANCN), RAD50, RAD51, RAP80, and TOPBP1, and was associated with time to breast and ovarian cancer diagnosis.
The Lys63-specific deubiquitinating enzyme BRCC36 is regulated by two scaffold proteins localizing in different subcellular compartments.
Chen et al., Houston, United States. In J Biol Chem, 2010
We and others showed previously that BRCC36 is a component of the BRCA1-A complex, which consists of RAP80, CCDC98/ABRAXAS, BRCC45/BRE, MERIT40/NBA1, BRCC36, and BRCA1.
Analysis of the genes coding for the BRCA1-interacting proteins, RAP80 and Abraxas (CCDC98), in high-risk, non-BRCA1/2, multiethnic breast cancer cases.
Tischkowitz et al., Montréal, Canada. In Breast Cancer Res Treat, 2009
it seems unlikely that moderate to highly penetrant alleles of either RAP80 or Abraxas, confer a significantly high relative risk of breast cancer.
Familial breast cancer screening reveals an alteration in the RAP80 UIM domain that impairs DNA damage response function.
Greenberg et al., Oulu, Finland. In Oncogene, 2009
Expression of the RAP80 delE81 allele impaired both BRCA1 and ABRA1 DSB recruitment, thus compromising BRCA1-mediated DDR signaling.
MERIT40 facilitates BRCA1 localization and DNA damage repair.
Chen et al., New Haven, United States. In Genes Dev, 2009
One of these complexes, which mediates the accumulation of BRCA1 at sites of DNA breaks, involves the ubiquitin-binding motif (UIM)-containing protein RAP80, a coiled-coil domain protein CCDC98/Abraxas, and a deubiquitinating enzyme BRCC36.
Evaluation of the BRCA1 interacting genes RAP80 and CCDC98 in familial breast cancer susceptibility.
Benítez et al., Madrid, Spain. In Breast Cancer Res Treat, 2009
Mutational analysis in 168 multiple-case breast/ovarian cancer families, negative for mutations in BRCA1 or BRCA2, suggests that CCDC98 does not play an important role as a high penetrance breast cancer susceptibility gene.
Customized treatment in non-small-cell lung cancer based on EGFR mutations and BRCA1 mRNA expression.
Taron et al., Badalona, Spain. In Plos One, 2008
examined RAP80 and Abraxas expression and their effect on treatment outcome in non-small-cell lung cancer
RAP80 and RNF8, key players in the recruitment of repair proteins to DNA damage sites.
Jetten et al., United States. In Cancer Lett, 2008
RAP80 is an ubiquitin-interaction motif (UIM) containing protein that is associated with a BRCA1/BARD1 complex through its interaction with CCDC98 (Abraxas).
New players in the BRCA1-mediated DNA damage responsive pathway.
Chen et al., New Haven, United States. In Mol Cells, 2008
These newly identified checkpoint proteins, including RNF8, RAP80 and CCDC98, work in concern in recruiting BRCA1 to DNA damage sites and thus regulate BRCA1 function in G2/M checkpoint control.
CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response.
Chen et al., New Haven, United States. In Nat Struct Mol Biol, 2007
CCDC98 is a mediator of BRCA1 function involved in the mammalian DNA damage response.
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