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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Sphingomyelin phosphodiesterase 3, neutral membrane

CCA1, nSMase2, neutral sphingomyelinase 2, SMPD3
mRNA accumulation occurs in a growth arrested confluent monolayer but not in subconfluent cells; may play a role in regulation of cell growth [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CLOCK, CAB, CAN, neutral sphingomyelinase, ACID
Papers on CCA1
The hyaluronic acid inhibitor 4-methylumbelliferone is an NSMase2 activator-role of Ceramide in MU anti-tumor activity.
Dawson et al., Chicago, United States. In Biochim Biophys Acta, Feb 2016
In a previous study we demonstrated the regulation of HA synthesis by ceramide, and now show how MU activated neutral sphingomyelinase2 (NSMase2) generates ceramides and mediates MU induced inhibition of HA synthesis, cell migration and invasion, and apoptosis of tumor cells.
MYB96 shapes the circadian gating of ABA signaling in Arabidopsis.
Seo et al., Chŏnju, South Korea. In Sci Rep, Dec 2015
The MYB96-TOC1 function might be also regulated by the clock component CIRCADIAN CLOCK-ASSOCIATED 1 (CCA1), which binds to the MYB96 promoter and alters its circadian expression.
AtHESPERIN: A Novel Regulator of Circadian Rhythms with Poly(A)-degrading Activity in Plants.
Papadopoulou et al., Lárisa, Greece. In Rna Biol, Dec 2015
Knockdown and overexpression of AtHESP in plant lines affects the expression and rhythmicity of the clock core oscillator genes TOC1 and CCA1.
Abnormal methylation status of FBXW10 and SMPD3, and associations with clinical characteristics in clear cell renal cell carcinoma.
Ye et al., Shanghai, China. In Oncol Lett, Nov 2015
Two DMRs located in the FBXW10 and SMPD3 genes were found to be hypermethylated in the 786-0 cells, but not in the normal kidney tissues.
Sphingolipid metabolism and its role in the skeletal tissues.
Murshed et al., Montréal, Canada. In Cell Mol Life Sci, Mar 2015
We provide an overview of the biology of sphingomyelin phosphodiesterase 3 (SMPD3), an important regulator of sphingolipid metabolism in the skeleton.
Roles and regulation of neutral sphingomyelinase-2 in cellular and pathological processes.
Hannun et al., Stony Brook, United States. In Adv Biol Regul, 2015
In this review, we focus on the roles and regulation of neutral sphingomyelinase 2 (nSMase2), an enzyme that generates the bioactive lipid ceramide through the hydrolysis of the membrane lipid sphingomyelin.
Revised Morning Loops of the Arabidopsis Circadian Clock Based on Analyses of Direct Regulatory Interactions.
Carré et al., Coventry, United Kingdom. In Plos One, 2014
We uncover novel, negative autoregulatory feedback loops from LHY and the closely related CIRCADIAN CLOCK ASSOCIATED-1 (CCA1) onto their own and each other's expression.
Lung injury and lung cancer caused by cigarette smoke-induced oxidative stress: Molecular mechanisms and therapeutic opportunities involving the ceramide-generating machinery and epidermal growth factor receptor.
Chung et al., Davis, United States. In Antioxid Redox Signal, 2014
To address this dichotomy in detail, evidence is presented regarding several protein targets, including Src, p38 mitogen-activated protein kinase, and neutral sphingomyelinase 2, the major sphingomyelinase that controls ceramide generation during oxidative stress.
Transcriptional versus non-transcriptional clocks: a case study in Ostreococcus.
Vergé et al., Paris, France. In Mar Genomics, 2014
A simplified version of the "green" plant clock, involving the master clock genes TOC1 and CCA1, has been revealed when the functional genomics and mathematical model approaches were combined.
Wheels within wheels: new transcriptional feedback loops in the Arabidopsis circadian clock.
McClung, United States. In F1000prime Rep, 2013
To date, the majority of plant transcription factors constituting these loops, including the central oscillator components CIRCADIAN CLOCK ASSOCIATED 1 (CCA1), LATE ELONGATED HYPOCOTYL (LHY), and TIMING OF CAB2 EXPRESSION 1 (TOC1), and the related PSEUDO-RESPONSE REGULATORS (PRRs), are transcriptional repressors, leading to a model of the clock emphasizing repressive interactions.
Neutral sphingomyelinase 2 deficiency increases hyaluronan synthesis by up-regulation of Hyaluronan synthase 2 through decreased ceramide production and activation of Akt.
Dawson et al., Chicago, United States. In J Biol Chem, 2012
NSMase2/Cer are the key mediators of the regulation of HA synthesis, via microdomains and the Akt/mTOR pathway
Neutral sphingomyelinase 2 activity and protein stability are modulated by phosphorylation of five conserved serines.
Goldkorn et al., Davis, United States. In J Biol Chem, 2012
initial structure/function insights regarding nSMase2 phosphorylation
A key role for matrix metalloproteinases and neutral sphingomyelinase-2 in transplant vasculopathy triggered by anti-HLA antibody.
Salvayre et al., Toulouse, France. In Circulation, 2012
MMP2 and neutral sphingomyelinase-2 play a role in vasculopathy triggered by a humoral immune response in transplants.
Protein phosphatase 2A and neutral sphingomyelinase 2 regulate IRAK-1 protein ubiquitination and degradation in response to interleukin-1beta.
Nikolova-Karakashian et al., Lexington, United States. In J Biol Chem, 2011
NSMase-2- and PP2A-dependent regulation of IRAK-1 degradation is a novel mechanism to fine tune the magnitude of IL-1beta response.
A cell-autonomous requirement for neutral sphingomyelinase 2 in bone mineralization.
Murshed et al., Montréal, Canada. In J Cell Biol, 2011
The Col1a1-Smpd3 mice, in which osteoblast-specific expression of Smpd3 corrected the bone abnormalities observed in fro/fro embryos without affecting the cartilage phenotype.
Coordinated transcriptional regulation underlying the circadian clock in Arabidopsis.
Wang et al., New Haven, United States. In Nat Cell Biol, 2011
Here, we show that in Arabidopsis thaliana, FHY3, FAR1 and HY5, three positive regulators of the phytochrome A signalling pathway, directly bind to the promoter of ELF4, a proposed component of the central oscillator, and activate its expression during the day, whereas the circadian-controlled CCA1 and LHY proteins directly suppress ELF4 expression periodically at dawn through physical interactions with these transcription-promoting factors.
Timing of plant immune responses by a central circadian regulator.
Dong et al., Durham, United States. In Nature, 2011
Here we report the identification of novel genes involved in R-gene-mediated resistance against downy mildew in Arabidopsis and their regulatory control by the circadian regulator, CIRCADIAN CLOCK-ASSOCIATED 1 (CCA1).
Circadian rhythms persist without transcription in a eukaryote.
Millar et al., Edinburgh, United Kingdom. In Nature, 2011
The unicellular pico-eukaryotic alga Ostreococcus tauri possesses a naturally minimized clock, which includes many features that are shared with plants, such as a central negative feedback loop that involves the morning-expressed CCA1 and evening-expressed TOC1 genes.
A functional genomics approach reveals CHE as a component of the Arabidopsis circadian clock.
Kay et al., San Diego, United States. In Science, 2009
In Arabidopsis, a core loop is established between CCA1 and TOC1.
The circadian clock in Arabidopsis roots is a simplified slave version of the clock in shoots.
Nimmo et al., Glasgow, United Kingdom. In Science, 2009
Two of the feedback loops of the plant circadian clock are disengaged in roots, because two key clock components, the transcription factors CCA1 and LHY, are able to inhibit gene expression in shoots but not in roots.
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