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CREB binding protein

CBP, CREB-Binding Protein
This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009] (from NCBI)
Top mentioned proteins: p300, CREB, Histone, CAN, V1a
Papers using CBP antibodies
Interaction of p21(CDKN1A) with PCNA regulates the histone acetyltransferase activity of p300 in nucleotide excision repair.
Imperiale Michael, In PLoS Pathogens, 2007
... (SY8) were purchased from Santa Cruz Biotechnology; antibodies to AKT, phospho AKT (Ser 473) and CBP were purchased from Cell Signaling Technology; antibodies to HA ...
LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF
Golenbock Douglas T. et al., In The Journal of Experimental Medicine, 2002
... Polyclonal antibodies to IRF-3 were from Zymed Laboratories, and CBP were from Santa Cruz Biotechnology, Inc ...
Large-scale analysis of the human and mouse transcriptomes.
Snyder Michael, In PLoS Genetics, 2001
... used to immunoprecipitate extracts treated with one of the following antibodies; polyclonal ETS1, sc-355; polyclonal CBP, A-22; (Santa Cruz Biotechnology), or monoclonal RUNX, α3.2.3.1 ...
Inherited and environmentally induced differences in mutation frequencies between wild strains of Sordaria fimicola from “Evolution Canyon”.
Perrimon Norbert, In PLoS Genetics, 1997
... Samakovlis, 1∶500), CBP-FITC (New England BioLabs, 1∶500), WGA-488 (Molecular Probes, ...
Papers on CBP
Androgen Receptor Coactivators in Regulation of Growth and Differentiation in Prostate Cancer.
Culig, Innsbruck, Austria. In J Cell Physiol, Feb 2016
Transcriptional integrators p300 and CBP are up-regulated by androgen ablation and may influence antagonist/agonist balance of non-steroidal anti-androgens.
Just a Flexible Linker? The Structural and Dynamic Properties of CBP-ID4 Revealed by NMR Spectroscopy.
Pierattelli et al., Florence, Italy. In Biophys J, Feb 2016
ID4 is the fourth intrinsically disordered linker of CREB-binding protein (CBP).
Suppression of type I interferon production by porcine epidemic diarrhea virus and degradation of CREB-binding protein by nsp1.
Yoo et al., Urbana, United States. In Virology, Feb 2016
PEDV nsp1 did not interfere the IRF3 phosphorylation and nuclear translocation but interrupted the enhanceosome assembly of IRF3 and CREB-binding protein (CBP) by degrading CBP.
Resetting the epigenome for heart regeneration.
Hudson et al., Brisbane, Australia. In Semin Cell Dev Biol, Feb 2016
BMP, bone morphogenetic protein; Bvht, Braveheart; CBP, CREB-binding protein; Cdkn, cyclin dependent kinase inhibitor; DOT1L, disruptor of telomeric silencing-1; DNMTs, DNA methyltransferases; eRNAs, enhancer RNAs; ESCs, embryonic stem cells; FGF, fibroblast growth factor; FOX, Forkhead box; Gcn5, general control of amino acid synthesis protein 5; HATs, histone acetyl transferases; HDACs, histone deacteylases; H3K27, histone 3, lysine 27; HMTs, histone methyltransferases; Jmj, Jumonji; JMJD3, Jumonji domain-containing protein 3; KDMs, histone lysine demethylases; lncRNAs, long non-coding RNAs; Mhrt, Myheart; miRNAs, microRNAs; Myh, myosin heavy chain; PRC2, polycomb repressive complex 2; PSCs, pluripotent stem cells; PTM, post-translational modification; SIRTs, Sirtuins; SMYD1, SET and MYND domain containing 1; Srf, serum response factor; TET, Ten-eleven translocation; TGF-β, transforming growth factor beta; TFs, transcription factors; UTX, ubiquitously transcribed tetratricopeptide repeat, X chromosome.
Epigenetic (re)programming of caste-specific behavior in the ant Camponotus floridanus.
Berger et al., Philadelphia, United States. In Science, Feb 2016
We found that these behaviors are regulated by histone acetylation likely catalyzed by the conserved acetyltransferase CBP.
Brain-derived neurotrophic factor and its clinical implications.
Das et al., Vishākhapatnam, India. In Arch Med Sci, Jan 2016
BDNF binds to its high affinity receptor TrkB (tyrosine kinase B) and activates signal transduction cascades (IRS1/2, PI3K, Akt), crucial for CREB and CBP production, that encode proteins involved in β cell survival.
Homocysteine induces glyceraldehyde-3-phosphate dehydrogenase acetylation and apoptosis in the neuroblastoma cell line Neuro2a.
Liu et al., Shanghai, China. In Braz J Med Biol Res, Dec 2015
We found that nuclear translocation and acetylation of GAPDH increased in the presence of 5 mM Hcy and that higher levels of acetyltransferase p300/CBP were detected in Neuro2a cells.
Therapeutic targets in the Wnt signaling pathway: Feasibility of targeting TNIK in colorectal cancer.
Yamada et al., Tokyo, Japan. In Pharmacol Ther, Dec 2015
Several therapeutics targeting various molecular components of the Wnt signaling pathway, including porcupine, frizzled receptors and co-receptor, tankyrases, and cAMP response element binding protein (CREB)-binding protein (CBP), have been developed, and some of those are currently being evaluated in early-phase clinical trials.
The Potential Role of Amygdaloid MicroRNA-494 in Alcohol-Induced Anxiolysis.
Pandey et al., Chicago, United States. In Biol Psychiatry, Dec 2015
Expression of miR-494 was significantly decreased, whereas expression of the binding protein of cyclic adenosine monophosphate response element binding protein (CBP), p300, and Cbp/p300-interacting transactivator 2 (Cited2) was increased in the amygdala during ethanol-induced anxiolysis.
Reciprocal regulation of p53 and NF-κB by diacylglycerol kinase ζ.
Goto et al., Yamagata, Japan. In Adv Biol Regul, Nov 2015
Furthermore, DGKζ deficiency is shown to promote increased association of p65 subunit with the transcriptional cofactor CBP.
CREB-binding protein, p300, butyrate, and Wnt signaling in colorectal cancer.
Lazarova et al., Scranton, United States. In World J Gastroenterol, Aug 2015
This paper reviews the distinctive roles played by the transcriptional coactivators CREB-binding protein (CBP) and p300 in Wnt/β-catenin signaling and cell physiology in colorectal cancer (CRC).
Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element.
Look et al., Boston, United States. In Science, 2015
MYB binds to this new site and recruits its H3K27 acetylase-binding partner CBP, as well as core components of a major leukemogenic transcriptional complex that contains RUNX1, GATA-3, and TAL1 itself.
Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages.
Yang et al., Taipei, Taiwan. In Cancer Cell, 2014
Here, we found that CREB-binding protein (CBP) is the critical factor in Snail-mediated target gene transactivation.
An acetate switch regulates stress erythropoiesis.
Garcia et al., Dallas, United States. In Nat Med, 2014
We previously reported that the lysine acetyltransferase CREB-binding protein (CBP) is required for HIF-2α acetylation and efficient HIF-2-dependent EPO induction during hypoxia.
Osteopontin-CD44 signaling in the glioma perivascular niche enhances cancer stem cell phenotypes and promotes aggressive tumor growth.
Holland et al., Seattle, United States. In Cell Stem Cell, 2014
These effects were mediated via the γ-secretase-regulated intracellular domain of CD44, which promoted aggressive glioma growth in vivo and stem cell-like phenotypes via CBP/p300-dependent enhancement of HIF-2α activity.
The acetylase/deacetylase couple CREB-binding protein/Sirtuin 1 controls hypoxia-inducible factor 2 signaling.
Garcia et al., Dallas, United States. In J Biol Chem, 2012
The acetylase/deacetylase couple CREB-binding protein/Sirtuin 1 controls hypoxia-inducible factor 2 signaling.
Modulation of proximal signaling in normal and transformed B cells by transmembrane adapter Cbp/PAG.
Berge et al., Oslo, Norway. In Exp Cell Res, 2012
findings support a negative regulatory function for Cbp/PAG in proximal B cell receptor signaling in normal and EBV-transformed B cells
Peroxiredoxins and tropomyosins as plasma biomarkers for lung cancer and asbestos exposure.
Anttila et al., Espoo, Finland. In Lung Cancer, 2012
Plasma peroxiredoxins 1 and 2, and tropomyosin 4 were shown to associate with asbestos-exposure, and peroxiredoxin 1 with lung cancer.
E2A and CBP/p300 act in synergy to promote chromatin accessibility of the immunoglobulin κ locus.
Agata et al., Kyoto, Japan. In J Immunol, 2012
Overexpression of CBP/p300 in conjunction with E2A results in enhancement of E2A-induced histone acetylation, germline transcription, and immunoglobulin (Ig)kappa light chain rearrangement.
Human peroxiredoxin 1 modulates TGF-β1-induced epithelial-mesenchymal transition through its peroxidase activity.
Jang et al., Inch'ŏn, South Korea. In Biochem Biophys Res Commun, 2012
These findings provide new insight into the role of hPrx1 in regulating TGF-beta1-induced epithelial-mesenchymal transition .
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