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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Cannabinoid receptor 1

CB1, cannabinoid receptor, CB1 cannabinoid receptor
This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009] (from NCBI)
Top mentioned proteins: CAN, ACID, V1a, HAD, fatty acid amide hydrolase
Papers using CB1 antibodies
CB1 antagonists for obesity--what lessons have we learned from rimonabant?
Roche Régis et al., In Journal of Inflammation (London, England), 2008
... 2-Arachidonoyl glycerol and R1-Methanandamide (2-AG and R1-Met, CB1 agonist, Cayman) were obtained from SpiBio ...
Functional expression of Ca2+ signaling pathways in mouse embryonic stem cells.
Zwaka Thomas, In PLoS ONE, 2003
... ACEA and the cannabinoid receptor antagonists AM251 and AM630 were purchased from Tocris (Ellisville, MO) ...
Endocannabinoid signaling via cannabinoid receptor 1 is involved in ethanol preference and its age-dependent decline in mice.
Bartolomucci Alessandro, In PLoS ONE, 2002
... In the first set of experiments, WT and CB1-KO mice were injected intraperitoneally (ip) with 500 µg/kg THC (Tocris, Avonmouth, UK) and 500 ...
Papers on CB1
Chronic alcohol exposure disrupts CB1 regulation of GABAergic transmission in the rat basolateral amygdala.
Roberto et al., Los Angeles, United States. In Addict Biol, Feb 2016
The endogenous cannabinoid/type 1 cannabinoid receptor (eCB/CB1 ) system curbs BLA-driven anxiety and stress responses via a retrograde negative feedback system that inhibits neurotransmitter release, and BLA CB1 activation reduces GABA release and drives anxiogenesis.
The Pharmacological Basis of Cannabis Therapy for Epilepsy.
Golub et al., United States. In J Pharmacol Exp Ther, Feb 2016
CBD is anticonvulsant, but it has a low affinity for the cannabinoid CB1 and CB2 receptors; therefore the exact mechanism by which it affects seizures remains poorly understood.
The endocannabinoid system and NGF are involved in the mechanism of action of resveratrol: a multi-target nutraceutical with therapeutic potential in neuropsychiatric disorders.
Dinarvand et al., Tehrān, Iran. In Psychopharmacology (berl), Feb 2016
In the case of any significant alteration of brain eCB or NGF level, the effect of pre-treatment with cannabinoid CB1 or CB2 receptor antagonist (AM251 or SR144528) was investigated.
Effect of JWH-250, JWH-073 and their interaction on "tetrad", sensorimotor, neurological and neurochemical responses in mice.
Marti et al., Ferrara, Italy. In Prog Neuropsychopharmacol Biol Psychiatry, Feb 2016
UNASSIGNED: JWH-250 and JWH-073 are two synthetic cannabinoid agonists with nanomolar affinity at CB1 and CB2 receptors.
Role of hypothalamic cannabinoid receptors in post-stroke depression in rats.
Jia et al., Beijing, China. In Brain Res Bull, Feb 2016
We then assessed the expression of CB1 and CB2 receptors in the hypothalamus, and evaluated the effects of pharmacological stimulations of CB1 or CB2 receptors on the expression and development of depression-like behaviors in PSD rats.
Ligands for cannabinoid receptors, promising anticancer agents.
Manayi et al., Tehrān, Iran. In Life Sci, Feb 2016
These compounds along with endocannabinoids, a group of neuromodulator compounds in the body especially in brain, express their effects by activation of G-protein-coupled cannabinoid receptors, CB1 and CB2.
Management of non-alcoholic fatty liver disease in 2015.
Beaton et al., London, Canada. In World J Hepatol, Jan 2016
The study of anti-fibrotic agents such as pentoxifylline and FXR agonists hold promise and new pathways, such as hepatocyte cannabinoid receptor antagonists are being studied.
An Introduction to the Endogenous Cannabinoid System.
Mackie et al., Bloomington, United States. In Biol Psychiatry, Nov 2015
The most abundant cannabinoid receptors are the CB1 cannabinoid receptors; however, CB2 cannabinoid receptors, transient receptor potential channels, and peroxisome proliferator activated receptors are also engaged by some cannabinoids.
β-Neurexins Control Neural Circuits by Regulating Synaptic Endocannabinoid Signaling.
Südhof et al., Stanford, United States. In Cell, Aug 2015
The β-neurexin knockout phenotype was attenuated by CB1-receptor inhibition, which blocks presynaptic endocannabinoid signaling, or by 2-arachidonoylglycerol synthesis inhibition, which impairs postsynaptic endocannabinoid release.
Weeding out bad waves: towards selective cannabinoid circuit control in epilepsy.
Watanabe et al., Irvine, United States. In Nat Rev Neurosci, May 2015
As retrograde signalling molecules, endocannabinoids are synthesized postsynaptically but activate presynaptic cannabinoid receptor 1 (CB1) receptors to inhibit neurotransmitter release.
Small Molecules from Nature Targeting G-Protein Coupled Cannabinoid Receptors: Potential Leads for Drug Discovery and Development.
Ojha et al., Abu Dhabi, United Arab Emirates. In Evid Based Complement Alternat Med, 2014
The cannabinoid molecules are derived from Cannabis sativa plant which acts on the cannabinoid receptors types 1 and 2 (CB1 and CB2) which have been explored as potential therapeutic targets for drug discovery and development.
Chemical approaches to therapeutically target the metabolism and signaling of the endocannabinoid 2-AG and eicosanoids.
Nomura et al., Berkeley, United States. In Chem Soc Rev, 2014
While THC and its derivatives have garnered notoriety in the eyes of the public, the endocannabinoid system consists of two endogenous signaling lipids, 2-arachidonoylglycerol (2-AG) and N-arachidonoylethanolamine (anandamide), which activate cannabinoid receptors CB1 and CB2 in the nervous system and peripheral tissues.
Pregnenolone can protect the brain from cannabis intoxication.
Piazza et al., Bordeaux, France. In Science, 2014
The administration of the main active principle of Cannabis sativa (marijuana), Δ(9)-tetrahydrocannabinol (THC), substantially increases the synthesis of pregnenolone in the brain via activation of the type-1 cannabinoid (CB1) receptor.
Δ9-THC-caused synaptic and memory impairments are mediated through COX-2 signaling.
Chen et al., New Orleans, United States. In Cell, 2013
COX-2 induction by Δ(9)-THC is mediated via CB1 receptor-coupled G protein βγ subunits.
A Novel Isoform of the Hepatic Antimicrobial Peptide, Hepcidin (Hepc-CB1), from a Deep-Sea Fish, the Spinyjaw Greeneye Chlorophthalmus bicornis (Norman, 1939): Molecular Characterisation and Phylogeny.
Bright Singh et al., Cochin, India. In Probiotics Antimicrob Proteins, 2013
In the present study, we report a 87-amino acid (aa) preprohepcidin (Hepc-CB1) with a signal peptide of 24 aa, a prodomain of 39 aa and a bioactive mature peptide of 24 aa from the gill mRNA transcripts of the deep-sea fish spinyjaw greeneye, Chlorophthalmus bicornis.
Angiotensin II induces vascular endocannabinoid release, which attenuates its vasoconstrictor effect via CB1 cannabinoid receptors.
Hunyady et al., Budapest, Hungary. In J Biol Chem, 2012
Ang II stimulates vascular endocannabinoid formation, which attenuates its vasoconstrictor effect, suggesting that endocannabinoid release from the vascular wall and CB(1)R activation reduces the vasoconstrictor and hypertensive effects of Ang II.
TRPV1-mediated calcium signal couples with cannabinoid receptors and sodium-calcium exchangers in rat odontoblasts.
Shibukawa et al., Chiba, Japan. In Cell Calcium, 2012
the cAMP-mediated CB1-TRPV1 crosstalk plays an important role in driving cellular functions following transduction of external stimuli to odontoblasts.
Ectopic pregnancy is associated with high anandamide levels and aberrant expression of FAAH and CB1 in fallopian tubes.
Konje et al., Leicester, United Kingdom. In J Clin Endocrinol Metab, 2012
Cannabinoid receptors and endocannabinoid modulating enzymes were localized in fallopian tube epithelium by immunohistochemistry and showed reduced CB1 and FAAH expression in ectopic pregnancy
Cannabinoid receptor 1 in the vagus nerve is dispensable for body weight homeostasis but required for normal gastrointestinal motility.
Elmquist et al., Dallas, United States. In J Neurosci, 2012
These results unveil CB(1)R in the vagus nerve as a key component underlying normal gastrointestinal motility.
Effects of cannabinoid receptor agonist WIN 55,212-2 on blood-brain barrier disruption in focal cerebral ischemia in rats.
Weiss et al., New Brunswick, United States. In Pharmacology, 2011
These data suggest an involvement of CB1 receptors in the regulation of blood brain barrier disruption in the early stage of stroke
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