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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Calcium channel, voltage-dependent, L type, alpha 1C subunit

Cav1.2, CACNA1C
This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, V1a, SCN5A, AGE
Papers using Cav1.2 antibodies
Colocalization of fluorescent markers in confocal microscope images of plant cells.
Chien Kenneth R., In PLoS Biology, 2007
... Human Cav1.2 was obtained from Origene.
Papers on Cav1.2
Transcriptome profiling in oral cavity and esophagus tissues from (S)-N'-nitrosonornicotine-treated rats reveals candidate genes involved in human oral cavity and esophageal carcinogenesis.
Kassie et al., Richmond, United States. In Mol Carcinog, Feb 2016
Furthermore, interrogation of TCGA data sets showed that genes deregulated by (S)-NNN in rat tissues (Fetub, Ly6e, Nr1d1, Cacna1c, Cd80, and Dgkg) are also altered in esophageal and head and neck tumors.
The impact of CACNA1C allelic variation on regional gray matter volume in Chinese population.
Li et al., China. In Am J Med Genet B Neuropsychiatr Genet, Feb 2016
UNASSIGNED: The SNP rs1006737 in CACNA1C gene has been significantly associated with psychiatric disorders (e.g., schizophrenia and bipolar disorder) in European populations.
Identification of glycosylation sites essential for surface expression of the CaVα2δ 1 subunit and modulation of the cardiac CaV1.2 channel activity.
Parent et al., Montréal, Canada. In J Biol Chem, Feb 2016
CaVα2δ1 is potentially the most heavily N-glycosylated subunit in the CaV1.2 channel complex.
Isoproterenol Promotes Rapid Ryanodine Receptor Movement to BIN1 Organized Dyads.
Hong et al., Los Angeles, United States. In Circulation, Feb 2016
BACKGROUND: -The key pathophysiology of human acquired heart failure is impaired calcium transient, which is initiated at dyads consisting ryanodine receptors (RyR) at sarcoplasmic reticulum apposing CaV1.2 channels at t-tubules.
Regulation of SCN3B/scn3b by Interleukin 2 (IL-2): IL-2 modulates SCN3B/scn3b transcript expression and increases sodium current in myocardial cells.
Tu et al., Wuhan, China. In Bmc Cardiovasc Disord, Dec 2015
METHODS: In the present study, we observed the effect of IL-2 by qRT-PCR on the transcription of ion channel genes including SCN2A, SCN3A, SCN4A, SCN5A, SCN9A, SCN10A, SCN1B, SCN2B, SCN3B, KCNN1, KCNJ5, KCNE1, KCNE2, KCNE3, KCND3, KCNQ1, KCNA5, KCNH2 and CACNA1C.
CACNA1C rs1006737 genotype and bipolar disorder: Focus on intermediate phenotypes and cardiovascular comorbidity.
Goldstein et al., Toronto, Canada. In Neurosci Biobehav Rev, Aug 2015
Recently, multiple genome-wide association studies have identified a genetic polymorphism (CACNA1C rs1006737) that appears to confer susceptibility for BD.
Molecular neurobiological clues to the pathogenesis of bipolar disorder.
Harrison, Oxford, United Kingdom. In Curr Opin Neurobiol, Aug 2015
Recent genome-wide association studies have identified the first loci, implicating genes such as CACNA1C and ANK3.
Molecular Aspects of Modulation of L-type Calcium Channels by Protein Kinase C.
Dascal et al., Tel Aviv-Yafo, Israel. In Curr Mol Pharmacol, 2014
Ca(2+) influx via L-type Ca(2+) channel (L-VDCC; CaV1.2) is required for cardiac and smooth muscle contraction.
Direct Estimation of CaV1.2 Gating Parameters: Quantification of Voltage Sensor - Pore Transductions and their Modulation by FLP 64176.
Steffen et al., Vienna, Austria. In Curr Mol Pharmacol, 2014
Here we propose a technique enabling the estimation of FPL 64174 effects on rate constants of the voltage sensing machinery and pore transitions from macroscopic CaV1.2 current kinetics making use of a hybrid stochastic-deterministic optimization procedure.
Regulation of Cardiac Calcium Channels in the Fight-or-Flight Response.
Catterall, Seattle, United States. In Curr Mol Pharmacol, 2014
In this article, I review experimental results that have emerged over several years showing that cardiac CaV1.2 channels form a local signaling complex, in which their proteolytically processed distal C-terminal domain, an A-Kinase Anchoring Protein, and cyclic AMP-dependent protein kinase (PKA) interact directly with the transmembrane core of the ion channel through the proximal C-terminal domain.
L-type CaV1.2 calcium channels: from in vitro findings to in vivo function.
Wegener et al., In Physiol Rev, 2014
The L-type Cav1.2 calcium channel is present throughout the animal kingdom and is essential for some aspects of CNS function, cardiac and smooth muscle contractility, neuroendocrine regulation, and multiple other processes.
Genetics of bipolar disorder.
Sklar et al., Cardiff, United Kingdom. In Lancet, 2013
Robust and replicable genome-wide significant associations have recently been reported in genome-wide association studies at several common polymorphisms, including variants within the genes CACNA1C, ODZ4, and NCAN.
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
Cross-Disorder Group of the Psychiatric Genomics Consortium, In Lancet, 2013
FINDINGS: SNPs at four loci surpassed the cutoff for genome-wide significance (p<5×10(-8)) in the primary analysis: regions on chromosomes 3p21 and 10q24, and SNPs within two L-type voltage-gated calcium channel subunits, CACNA1C and CACNB2.
Mutation of the calmodulin binding motif IQ of the L-type Ca(v)1.2 Ca2+ channel to EQ induces dilated cardiomyopathy and death.
Hofmann et al., München, Germany. In J Biol Chem, 2012
Mutation of the IQ motif to IE leads to dilated cardiomyopathy and death.
Protein phosphatase 2A effectively modulates basal L-type Ca(2+) current by dephosphorylating Ca(v)1.2 at serine 1866 in mouse cardiac myocytes.
Zhang et al., Nanjing, China. In Biochem Biophys Res Commun, 2012
these data reveal the functional role of PP2A in cardiac Ca(v)1.2 regulation.
Decreased cardiac L-type Ca²⁺ channel activity induces hypertrophy and heart failure in mice.
Molkentin et al., Cincinnati, United States. In J Clin Invest, 2012
alpha1C-/- mice subjected to pressure overload stimulation, isoproterenol infusion, and swimming showed greater cardiac hypertrophy, greater reductions in ventricular performance, and greater ventricular dilation than alpha1C+/+ controls
Single-channel monitoring of reversible L-type Ca(2+) channel Ca(V)α(1)-Ca(V)β subunit interaction.
Herzig et al., Köln, Germany. In Biophys J, 2012
HEK293alpha(1C) cells expressing the Ca(V)1.2 subunit were transiently transfected with Ca(V)alpha(2)delta1 alone or with Ca(V)beta(1a), Ca(V)beta(2b)showed increased whole-cell current and shifted the voltage dependence of activation and inactivation to hyperpolarization.
Distinct RGK GTPases differentially use α1- and auxiliary β-binding-dependent mechanisms to inhibit CaV1.2/CaV2.2 channels.
Colecraft et al., New York City, United States. In Plos One, 2011
new mechanistic perspectives, and reveal unexpected variations in determinants, underlying inhibition of Ca(V)1.2/Ca(V)2.2 channels by distinct RGK GTPases.
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
Psychiatric GWAS Consortium Bipolar Disorder Working Group, New York City, United States. In Nat Genet, 2011
A combined GWAS analysis of schizophrenia and bipolar disorder yielded strong association evidence for Single Nucleotide Polymorphism in CACNA1C.
Genome-wide association study identifies five new schizophrenia loci.
Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium, Boston, United States. In Nat Genet, 2011
In a joint analysis with a bipolar disorder sample (16,374 affected individuals and 14,044 controls), three loci reached genome-wide significance: CACNA1C (rs4765905, P = 7.0 × 10(-9)), ANK3 (rs10994359, P = 2.5 × 10(-8)) and the ITIH3-ITIH4 region (rs2239547, P = 7.8 × 10(-9)).
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