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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Cathepsin Z

cathepsin X, cathepsin Z, cathepsin P, CTSZ
The protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis. [provided by RefSeq, Oct 2008] (from NCBI)
Top mentioned proteins: Cathepsins, CAN, carboxypeptidase, ACID, CD11b
Papers on cathepsin X
Lysosomal dysfunction and impaired autophagy in a novel mouse model deficient for the lysosomal membrane protein Cln7.
Storch et al., Hamburg, Germany. In Hum Mol Genet, Jan 2016
By immunohistochemical co-stainings, increased cathepsin Z expression restricted to Cln7-deficient microglia and neurons was found.
Relationships between PROMPT and gene expression.
Jensen et al., Århus, Denmark. In Rna Biol, Dec 2015
For the CTSZ and DAP genes we find that TFIIB and TBP promoter binding decrease when PROMPTs accumulate.
Mannose 6-phosphate-independent Lysosomal Sorting of LIMP-2.
Schwake et al., Kiel, Germany. In Traffic, Oct 2015
Finally, cathepsin Z, a known GlcNAc-1-phosphotransferase substrate, but not LIMP-2, could be precipitated with M6P-specific antibodies.
Multiple Cathepsins Promote Pro-IL-1β Synthesis and NLRP3-Mediated IL-1β Activation.
Rock et al., Worcester, United States. In J Immunol, Sep 2015
Also, we evaluate endogenous cathepsin inhibitors cystatins C and B. Surprisingly, we find that multiple redundant cathepsins, inhibited by Ca074Me and cystatins, promote pro-IL-1β synthesis, and to our knowledge, we provide the first evidence that cathepsin X plays a nonredundant role in nonparticulate NLRP3 activation.
Intracellular signaling by cathepsin X: molecular mechanisms and diagnostic and therapeutic opportunities in cancer.
Pišlar et al., Ljubljana, Slovenia. In Semin Cancer Biol, Apr 2015
Cathepsin X is a cysteine carboxypeptidase, localized predominantly in immune cells, regulating their proliferation, maturation, migration and adhesion.
Expression of TGFβ superfamily components and other markers of oocyte quality in oocytes selected by brilliant cresyl blue staining: relevance to early embryonic development.
Smith et al., Al Jīzah, Egypt. In Mol Reprod Dev, Mar 2015
One objective of the present study was to assess the relationship between BCB staining, which correlates with an oocyte's developmental potential, and the transcript abundance for select TGFβ-superfamily components, SMAD2/3 and SMAD1/5 phosphorylation levels, and oocyte (JY1) and cumulus-cell (CTSB, CTSK, CTSS, and CTSZ) transcript markers in bovine oocytes and/or adjacent cumulus cells.
Status of autophagy, lysosome activity and apoptosis during corpus luteum regression in cattle.
Takahashi et al., Japan. In J Reprod Dev, 2014
Lysosome activation and expression of cathepsin-related genes (CTSB, CTSD, and CTSZ) showed significant increases in the late CL and were associated with an increase in cathepsin B protein.
A proteomic profile of synoviocyte lesions microdissected from formalin-fixed paraffin-embedded synovial tissues of rheumatoid arthritis.
Nishimura et al., Saitama, Japan. In Clin Proteomics, 2014
These include stromelysin-1 (MMP3), proteins S100-A8 and S100-A9, plastin-2, galectin-3, calreticulin, cathepsin Z, HLA-A, HLA-DRB1, ferritin, neutrophil defensin 1, CD14, MMP9 etc. CONCLUSIONS: Our results confirmed the involvement of known RA biomarkers such as stromelysin-1 (MMP3) and proteins S100-A8 and S100-A9, and also that of leukocyte antigens such as HLA-DRB1.
Evolutionary distance of amino acid sequence orthologs across macaque subspecies: identifying candidate genes for SIV resistance in Chinese rhesus macaques.
Smith et al., Davis, United States. In Plos One, 2014
Additionally, ANKRD30A, CTSZ, GORASP2, GTF2H1, IL13RA1, MUC16, NMDAR1, Notch1, NT5M, PDCD5, RAD50, and TM9SF2 were identified as possible candidates, among others.
Cathepsin X Cleaves Profilin 1 C-Terminal Tyr139 and Influences Clathrin-Mediated Endocytosis.
Kos et al., Ljubljana, Slovenia. In Plos One, 2014
Cathepsin X, a cysteine carboxypeptidase, is upregulated in several types of cancer.
Cysteine cathepsins as regulators of the cytotoxicity of NK and T cells.
Kos et al., Ljubljana, Slovenia. In Front Immunol, 2013
Cathepsin X promotes dendritic cell maturation, adhesion of macrophages, and migration of T cells.
Cathepsins L and Z are critical in degrading polyglutamine-containing proteins within lysosomes.
Goldberg et al., Boston, United States. In J Biol Chem, 2012
Cathepsins L and Z are critical in degrading polyglutamine-containing proteins within lysosomes.
LFA-1 fine-tuning by cathepsin X.
Kos et al., Ljubljana, Slovenia. In Iubmb Life, 2011
Cathepsin X, a cysteine carboxypeptidase, promotes T-cell migration and morphological changes by cleaving the β (2) cytoplasmic tail of LFA-1.
Cellular senescence induced by cathepsin X downregulation.
Nägler et al., München, Germany. In Eur J Cell Biol, 2011
cathepsin X deficiency leads to accelerated cellular senescence and consequently to diminished cellular proliferation and migration/invasion implying a potential role of cathepsin X in bypassing cellular senescence.
Cathepsin X cleavage of the beta2 integrin regulates talin-binding and LFA-1 affinity in T cells.
Kos et al., Ljubljana, Slovenia. In J Leukoc Biol, 2011
We show that sequential cleavage of C-terminal amino acids from the beta(2) cytoplasmic tail of LFA-1, by CatX, enhances binding of the adaptor protein talin to LFA-1 and triggers formation of the latter's high-affinity form
Polymorphisms in MC3R promoter and CTSZ 3'UTR are associated with tuberculosis susceptibility.
Hoal et al., Stellenbosch, South Africa. In Eur J Hum Genet, 2011
Polymorphisms in MC3R promoter and CTSZ 3'UTR are associated with tuberculosis susceptibility.
Overexpression of cathepsin Z contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma.
Guan et al., Hong Kong, Hong Kong. In Plos One, 2010
cathepsin Z contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma
The role of cathepsin X in cell signaling.
Obermajer et al., Ljubljana, Slovenia. In Cell Adh Migr, 2009
Cathepsin X is a lysosomal cysteine protease, found predominantly in cells of monocyte/macrophage lineage.
Visualization of protein interactions inside the secretory pathway.
Hauri et al., Basel, Switzerland. In Biochem Soc Trans, 2007
YFP PCA was successfully applied to visualize the protein interactions of the cargo transport receptor ERGIC-53 (endoplasmic reticulum-Golgi intermediate compartment protein of 53 kDa) with its luminal interaction partner MCFD2 (multiple coagulation factor deficiency protein 2) and its cargo proteins cathepsin Z and cathepsin C in a specific manner.
The lectin ERGIC-53 is a cargo transport receptor for glycoproteins.
Hauri et al., Basel, Switzerland. In Nat Cell Biol, 1999
Here we show that a cathepsin-Z-related glycoprotein binds to the recycling, mannose-specific membrane lectin ERGIC-53.
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