GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
Cathepsin G
cathepsin G
The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Jul 2008] (from
NCBI)
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Top mentioned proteins:
elastase, CAN, Trypsin, ACID, Chymotrypsin
Papers using
cathepsin G
antibodies
Adherent neutrophils activate endothelial myosin light chain kinaserole in transendothelial migration
Supplier
In The Journal of Experimental Medicine, 1997
... Sheep IgG against human elastase was from The Binding Site, and rabbit IgG against human cathepsin G was from Athens Research and Technology, Inc ...
Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa.
Supplier
In PLoS ONE, 1986
... Poland), human proteinase 3 (Pr3) (EC 3.4.21.76) was from Athens Research and Technology (Athens, USA) and cathepsin G (CatG) (EC 3.4.21.20) was from MP Biomedicals (Vannes, France) ...
Assay method for myeloperoxidase in human polymorphonuclear leukocytes
Supplier
In Oxidative Medicine and Cellular Longevity, 1982
... Cathepsin G inhibitor I was from Calbiochem (Merck KGaA, Darmstadt, Germany) ...
Papers on
cathepsin G
Neutrophil-Derived Proteases Escalate Inflammation through Activation of IL-36 Family Cytokines.
New
Dublin, Ireland. In Cell Rep, Feb 2016
Here, we show that IL-36α, IL-36β, and IL-36γ are activated differentially by the neutrophil granule-derived proteases cathepsin G, elastase, and proteinase-3, increasing their biological activity ∼500-fold.
In Vitro Mode of Action and Anti-thrombotic Activity of Boophilin, a Multifunctional Kunitz Protease Inhibitor from the Midgut of a Tick Vector of Babesiosis, Rhipicephalus microplus.
New
Bethesda, United States. In Plos Negl Trop Dis, Jan 2016
Furthermore, Boophilin abrogates cathepsin G- and plasmin-induced platelet aggregation and partially affects elastase-mediated cleavage of Tissue Factor Pathway Inhibitor (TFPI).
Lung inflammation promotes metastasis through neutrophil protease-mediated degradation of Tsp-1.
New
New York City, United States. In Proc Natl Acad Sci U S A, Jan 2016
Here, we show that extrinsic inflammation in the lungs leads to the recruitment of bone marrow-derived neutrophils, which degranulate azurophilic granules to release the Ser proteases, elastase and cathepsin G, resulting in the proteolytic destruction of the antitumorigenic factor thrombospondin-1 (Tsp-1).
Carboxyl-Terminal Cleavage of Apolipoprotein A-I by Human Mast Cell Chymase Impairs Its Anti-Inflammatory Properties.
New
Helsinki, Finland. In Arterioscler Thromb Vasc Biol, Jan 2016
APPROACH AND RESULTS: Activation of human mast cells triggered the release of granule-associated proteases chymase, tryptase, cathepsin G, carboxypeptidase A, and granzyme B. Among them, chymase cleaved apoA-I with the greatest efficiency and generated C-terminally truncated apoA-I, which failed to bind with high affinity to human coronary artery endothelial cells.
[Changes in serum protease and cytokine in patients with silicosis, tuberculosis, and lung cancer].
New
Wuxi, China. In Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi, Aug 2015
The variation trends of the expression of granzyme A, cathepsin G, apolipoprotein A, and interferon-β (IFN-β) were analyzed using enzyme-linked immunosorbent assay.
Protease-activated receptor 4: a critical participator in inflammatory response.
Review
New
Zhengzhou, China. In Inflammation, Apr 2015
The biological effect of PARs activated by coagulation proteases to regulate hemostasis and thrombosis plays an enormous role in the cardiovascular system, while PAR4 can also be activated by trypsin, cathepsin G, the activated factor X of the coagulation cascade, and trypsin IV.
Pathologic manifestations of levamisole-adulterated cocaine exposure.
Review
San Francisco, United States. In Diagn Pathol, 2014
This discrepancy is due to the fact that p-ANCA seen in association with levamisole-adulterated cocaine exposure is often directed against atypical p-ANCA-associated antigens within the neutrophil granules such as human neutrophil elastase, lactoferrin, and cathepsin G. Biopsies of the skin lesions reveal leukocytoclastic vasculitis often involving both superficial and deep dermal vessels.
Physiopathologic mechanisms involved in mare endometrosis.
Review
Lisbon, Portugal. In Reprod Domest Anim, 2014
A long-term in vitro exposure of mare endometrium explants to NETs components (myeloperoxidase, elastase and cathepsin G) up-regulated fibrosis markers TGFβ and Tissue inhibitor of metalloproteinase (TIMP-1).
Is the neutrophil a 'prima donna' in the procoagulant process during sepsis?
Review
In Crit Care, 2013
For instance, DNA initiates the intrinsic pathway, histones are a strong generator of thrombin, and granule proteins such as neutrophil elastase, cathepsin G and myeloperoxidase contribute to the suppression of the anticoagulation systems.
Inhibitors of cathepsin G: a patent review (2005 to present).
Review
Gdańsk, Poland. In Expert Opin Ther Pat, 2013
INTRODUCTION: Cathepsin G (CatG) is a neutral proteinase originating from human neutrophils.
The identification of a new role for LEKTI in the skin: The use of protein 'bait' arrays to detect defective trafficking of dermcidin in the skin of patients with Netherton syndrome.
GeneRIF
London, United Kingdom. In J Proteomics, 2012
major binding partners of LEKTI were found to be the antimicrobial peptide dermcidin and the serine protease cathepsin G and no kallikreins.
Sensor materials for the detection of human neutrophil elastase and cathepsin G activity in wound fluid.
GeneRIF
Graz, Austria. In Exp Dermatol, 2011
potential of HNE and CatG to be used as markers for early detection of infection. Significant differences in HNE and CatG levels in infected and non-infected wound fluids were observed.
Structure-activity analysis of cathepsin K/chondroitin 4-sulfate interactions.
GeneRIF
Edmonton, Canada. In J Biol Chem, 2011
distinct catK/C4-S interactions are necessary for the collagenolytic activity of the enzyme.
Invariant chain processing is independent of cathepsin variation between primary human B cells/dendritic cells and B-lymphoblastoid cells.
GeneRIF
Ulm, Germany. In Cell Immunol, 2010
CatG was found to be dispensable in invariant chain conversion within intact primary human B cells and dendritic cells.
Regulation of cathepsin G reduces the activation of proinsulin-reactive T cells from type 1 diabetes patients.
GeneRIF
Ulm, Germany. In Plos One, 2010
Data suggested the notion that CatG plays a critical role in proinsulin processing and is important in the activation process of diabetogenic T cells.
Neutrophil elastase, proteinase 3, and cathepsin G as therapeutic targets in human diseases.
Review
Impact
Tours, France. In Pharmacol Rev, 2010
Neutrophil elastase, proteinase 3, and cathepsin G are three hematopoietic serine proteases stored in large quantities in neutrophil cytoplasmic azurophilic granules.
Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases.
Impact
München, Germany. In Nat Med, 2010
Here we show that major microbicidal effectors of neutrophils, the serine proteases neutrophil elastase and cathepsin G, together with externalized nucleosomes, promote coagulation and intravascular thrombus growth in vivo.
Neutrophil serine proteases: specific regulators of inflammation.
Review
Impact
Saint Louis, United States. In Nat Rev Immunol, 2006
They engulf and degrade microorganisms using an array of weapons that include reactive oxygen species, antimicrobial peptides, and proteases such as cathepsin G, neutrophil elastase and proteinase 3.
Serine protease cathepsin G regulates adhesion-dependent neutrophil effector functions by modulating integrin clustering.
Impact
Saint Louis, United States. In Immunity, 2005
Here, we show that IC-activated cathepsin G- and neutrophil elastase-deficient (CG/NE) PMNs adhered normally to IC-coated surfaces but did not undergo CD11b clustering and failed to initiate cytoskeletal reorganization and cell spreading.
Proteinase-activated receptors: transducers of proteinase-mediated signaling in inflammation and immune response.
Review
Impact
Münster, Germany. In Endocr Rev, 2005
Serine proteinases such as thrombin, mast cell tryptase, trypsin, or cathepsin G, for example, are highly active mediators with diverse biological activities.
