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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Cathepsin B

cathepsin B
The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Cathepsins, PrP, V1a, ACID
Papers using cathepsin B antibodies
Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth
Lisanti Michael P. et al., In Cell Cycle, 2010
... #NBP1–00085, Novus; for immunostaining #2026–1, Epitomics), anti-LAMP1 [#sc-17768 (E-5); Santa Cruz Biotech], anti-BNIP-3 (#ab10433; Abcam), anti-Cathepsin B (#sc-13985 (FL-339); Santa Cruz Biotech), anti-OXPHOS (#MS601; Mitosciences), anti-β actin (#A5441, Sigma), ...
Liver injury caused by drugs: an update.
Bogyo Matthew, In PLoS ONE, 2009
... Irreversible cathepsin B specific inhibitor CA-074 was obtained from Bachem and the active site ...
MMP-13 and p53 in the progression of malignant peripheral nerve sheath tumors
Kim Kwangmeyung et al., In Theranostics, 2006
... block unspecific binding of the antibodies and each dish was incubated in the 1:200 diluted anti-cathepsin B mouse IgG (Abcam, Cambridge, MA) or anti-MMP-13 ...
Secondary necrosis is a source of proteolytically modified forms of specific intracellular autoantigens: implications for autoimmunity
Casiano Carlos A et al., In Molecular Cancer, 2000
... used: mouse monoclonal anti-poly (ADP-ribose) polymerase (PARP) AB-2 (Calbiochem), mouse monoclonal anti-β-actin (Sigma-Aldrich), goat polyclonal anti-cathepsin B (Santa Cruz Biotechnology), and horseradish peroxidase (HRP)-labeled ...
Papers on cathepsin B
Combined deletion of cathepsin protease family members reveals compensatory mechanisms in cancer.
Joyce et al., New York City, United States. In Genes Dev, Feb 2016
Here we demonstrate stage-dependent effects of simultaneously deleting cathepsin B (CtsB) and CtsS in a murine pancreatic neuroendocrine tumor model.
Tissue Levels of Stefin A and Stefin B in Hepatocellular Carcinoma.
Xie et al., Putian, China. In Anat Rec (hoboken), Feb 2016
The immunohistochemical staining of cathepsin B and cathepsin D, and the ratio of cathepsins to stefins were assessed.
Secondary amyloidosis in autoinflammatory diseases and the role of inflammation in renal damage.
Albertazzi et al., Piacenza, Italy. In World J Nephrol, Feb 2016
Serum amyloid A (SAA), as acute-phase protein with also proinflammatory properties, has been shown to induce the secretion of cathepsin B and inflammasome components from human macrophages.
The investigation of the prenatal and postnatal alcohol exposure-induced neurodegeneration in rat brain: protection by betaine and/or omega-3.
Yücel et al., Eskişehir, Turkey. In Childs Nerv Syst, Feb 2016
The effect of betaine and omega-3 in response to ethanol-induced changes on the brain, by biochemical analyses cytochrome c, caspase-3, calpain, cathepsin B and L, DNA fragmentation, histological and morfometric methods were evaluated.
Induction of Cell-Cell Fusion by Ebola Virus Glycoprotein: Low pH Is Not a Trigger.
Cohen et al., Atlanta, United States. In Plos Pathog, Jan 2016
Treating effector cells with a recombinant soluble cathepsin B or thermolysin, which cleaves GP into an active form, increases the extent of fusion, suggesting that a fraction of surface-expressed GP is not cleaved.
How microglia kill neurons.
Vilalta et al., Cambridge, United Kingdom. In Brain Res, Jan 2016
A number of mechanisms by which activated microglia kill neurons have been identified, including: (i) stimulation of the phagocyte NADPH oxidase (PHOX) to produce superoxide and derivative oxidants, (ii) expression of inducible nitric oxide synthase (iNOS) producing NO and derivative oxidants, (iii) release of glutamate and glutaminase, (iv) release of TNFα, (v) release of cathepsin B, (vi) phagocytosis of stressed neurons, and (vii) decreased release of nutritive BDNF and IGF-1.
A Novel High Content Imaging-Based Screen Identifies the Anti-Helminthic Niclosamide as an Inhibitor of Lysosome Anterograde Trafficking and Prostate Cancer Cell Invasion.
El-Osta et al., Shreveport, United States. In Plos One, Dec 2015
Previous studies from our laboratory have demonstrated that the anterograde (outward) movement of lysosomes to the cell surface in response to certain tumor microenvironment stimulus, such as hepatocyte growth factor (HGF) or acidic extracellular pH (pHe), increases cathepsin B secretion and tumor cell invasion.
Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitors.
Thatcher et al., Chicago, United States. In Acta Pharm Sin B, Nov 2015
This review provides a general update on strategies for cysteine protease inhibitor design and a focus on cathepsin B and calpain 1 as drug targets for neurodegenerative disorders; the latter focus providing an interesting query for the contemporary assumptions that irreversible, covalent protein modification and low selectivity are anathema to therapeutic safety and efficacy.
Cathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug Candidate.
Hook et al., San Diego, United States. In Front Neurol, 2014
This review presents supporting evidence for cathepsin B, a cysteine protease, as a potentially important drug target for TBI.
Microglial cell dysregulation in brain aging and neurodegeneration.
Eugenín et al., Santiago, Chile. In Front Aging Neurosci, 2014
Mitochondria-derived ROS and cathepsin B, are also necessary for the microglial cell production of interleukin-1β, a key inflammatory cytokine.
Natively inhibited Trypanosoma brucei cathepsin B structure determined by using an X-ray laser.
Chapman et al., Hamburg, Germany. In Science, 2013
The Trypanosoma brucei cysteine protease cathepsin B (TbCatB), which is involved in host protein degradation, is a promising target to develop new treatments against sleeping sickness, a fatal disease caused by this protozoan parasite.
Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth.
Ghiringhelli et al., Dijon, France. In Nat Med, 2013
Chemotherapy-triggered IL-1β secretion relied on lysosomal permeabilization and the release of cathepsin B, which bound to Nlrp3 and drove caspase-1 activation.
Cathepsin B is secreted apically from Xenopus 2F3 cells and cleaves the epithelial sodium channel (ENaC) to increase its activity.
Eaton et al., Atlanta, United States. In J Biol Chem, 2012
Cathepsin B may cleave ENaC extracellularly after being secreted or intracellularly, while ENaC is present in the Golgi or in recycling endosomes.
Cathepsin B controls the persistence of memory CD8+ T lymphocytes.
Ashton-Rickardt et al., London, United Kingdom. In J Immunol, 2012
Memory cells are protected from lysosomal breakdown by inhibition of CTSB; CTSB is a physiological target of (Spi)2A in memory CD8-positive T cell survival.
ErbB2-driven breast cancer cell invasion depends on a complex signaling network activating myeloid zinc finger-1-dependent cathepsin B expression.
Kallunki et al., Copenhagen, Denmark. In Mol Cell, 2012
signaling network activates the transcription of cathepsin B gene via myeloid zinc finger-1 transcription factor that binds to an ErbB2-responsive enhancer element in the first intron of cathepsin B
Biodegradable thermogels.
Jeong et al., Seoul, South Korea. In Acc Chem Res, 2012
The polypeptide copolymers were stable in the phosphate buffered saline, but the presence of proteolytic enzymes such as elastase, cathepsin B, cathepsin C, and matrix metallopreoteinase accelerated their degradation.
Urine and serum cathepsin B concentrations in the transitional cell carcinoma of the bladder.
Babjuk et al., Praha, Czech Republic. In J Clin Lab Anal, 2012
Cathepsin B concentrations correlate well with grading and invasivity of tumors.
Dysregulation of macrophage-secreted cathepsin B contributes to HIV-1-linked neuronal apoptosis.
Melendez et al., San Juan, Puerto Rico. In Plos One, 2011
the role of cathepsin B in neuronal cell death induced by HIV-infected macrophages
Stat3 controls lysosomal-mediated cell death in vivo.
Watson et al., Cambridge, United Kingdom. In Nat Cell Biol, 2011
Furthermore, although cell death through LMP is independent of executioner caspases 3, 6 and 7, it requires Stat3, which upregulates the expression of lysosomal proteases cathepsin B and L, while downregulating their endogenous inhibitor Spi2A (ref.
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals.
Latz et al., Worcester, United States. In Nature, 2010
Similarly, when injected intraperitoneally, cholesterol crystals induce acute inflammation, which is impaired in mice deficient in components of the NLRP3 inflammasome, cathepsin B, cathepsin L or IL-1 molecules.
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