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Catechol O-Methyltransferase, COMT
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008] (from NCBI)
Top mentioned proteins: AGE, HAD, CAN, iMpact, ACID
Papers on Catechol O-Methyltransferase
Genetic risk factors of cisplatin induced ototoxicity in adult patients.
Vogazianos et al., In Neoplasma, Feb 2016
Our study has demonstrated an association of early onset of CDDP induced ototoxicity with the presence of: two copies of GSTT1 gene (p=0,009) and with T allele of rs9332377 polymorphism in COMT gene (p=0,001).
Artificial neural network-based exploration of gene-nutrient interactions in folate and xenobiotic metabolic pathways that modulate susceptibility to breast cancer.
Kutala et al., Thanjāvūr, India. In Gene, Feb 2016
Multifactor dimensionality reduction analysis showed the following interactions in responders to folate: RFC1 G80A× MTHFR C677T (primary), COMT H108L×CYP1A1 m2 (secondary), MTR A2756G (tertiary).
Impact of physical exercise on catechol-O-methyltransferase activity in depressive patients: A preliminary communication.
Vieira-Coelho et al., Vila Real, Portugal. In J Affect Disord, Feb 2016
BACKGROUND: Catechol-O-methyltransferase (COMT) is a catabolic enzyme involved in the degradation of bioactive molecules including the neurotransmitters epinephrine, norepinephrine, and dopamine.
Genetic influences on the neural and physiological bases of acute threat: A research domain criteria (RDoC) perspective.
Koenen et al., Ban Mae Chan, Thailand. In Am J Med Genet B Neuropsychiatr Genet, Jan 2016
The most robust support has been demonstrated for associations between variation in the serotonin transporter (SLC6A4) and catechol-O-methyltransferase (COMT) genes with threat-related neural activation and physiological responses.
Modern treatment in Parkinson's disease, a personal approach.
Reichmann, Dresden, Germany. In J Neural Transm, Jan 2016
Similarly, and particularly if a wearing-off symptom is present, COMT inhibitors smoothen and prolong the action of levodopa.
Opicapone as an adjunct to levodopa in patients with Parkinson's disease and end-of-dose motor fluctuations: a randomised, double-blind, controlled trial.
Bi-Park 1 investigators et al., Lisbon, Portugal. In Lancet Neurol, Jan 2016
BACKGROUND: Opicapone is a novel, once-daily, potent third-generation catechol-O-methyltransferase inhibitor.
Underlying Mechanisms of Gene-Environment Interactions in Externalizing Behavior: A Systematic Review and Search for Theoretical Mechanisms.
Matthys et al., Amsterdam, Netherlands. In Clin Child Fam Psychol Rev, Dec 2015
Over the last decade, several candidate genes (i.e., MAOA, DRD4, DRD2, DAT1, 5-HTTLPR, and COMT) have been extensively studied as potential moderators of the detrimental effects of postnatal family adversity on child externalizing behaviors, such as aggression and conduct disorder.
The Role of the Catechol-o-Methyltransferase (COMT) GeneVal158Met in Aggressive Behavior, a Review of Genetic Studies.
Kennedy et al., Toronto, Canada. In Curr Neuropharmacol, Dec 2015
In recent years, there has been an increase in research in the molecular and genetic underpinnings of aggressive behavior, and one of the candidate genes codes for the catechol-O-methyltransferase (COMT).
Safinamide for symptoms of Parkinson's disease.
Müller, Berlin, Germany. In Drugs Today (barc), Nov 2015
Safinamide is a novel instrument for the drug therapy of Parkinson's disease with better safety and tolerability particularly concerning diarrhea than inhibitors of catechol-O-methyltransferase, like entacapone, according to an indirect comparison within a meta-analysis with entacapone.
Association between the COMT 158 G/A polymorphism and lung cancer risk: a meta-analysis.
Fan et al., China. In Int J Clin Exp Med, 2014
Catechol-O-methyltransferase (COMT) 158 G/A gene polymorphism seem to associate with lung cancer, but the results are inconclusive.
Analysis of CYP1A1 and COMT polymorphisms in women with cervical cancer.
Silva et al., São Paulo, Brazil. In Genet Mol Res, 2014
The aim of this case-control study was to obtain a comprehensive panel of genetic polymorphisms present only in genes (cytochrome P-450 1A1 - CYP1A1 and catechol-O-methyl transferase - COMT) within the metabolic pathway of sex steroids and determine their possible associations with the presence or absence of cervical cancer.
Pharmacological treatment of Parkinson disease: a review.
Lang et al., Hamilton, Canada. In Jama, 2014
Motor fluctuations may be managed by modifying the levodopa dosing regimen or by adding several other medications, such as MAOBIs, catechol-O-methyltransferase inhibitors, or dopamine agonists.
Association of OPRM1 and COMT single-nucleotide polymorphisms with hospital length of stay and treatment of neonatal abstinence syndrome.
Davis et al., Boston, United States. In Jama, 2013
Single-nucleotide polymorphisms (SNPs) in the μ-opioid receptor (OPRM1), multidrug resistance (ABCB1), and catechol-o-methyltransferase (COMT) genes are associated with risk for opioid addiction in adults.
Role of the apolipoprotein E and catechol-O-methyltransferase genes in prospective and retrospective memory traits.
Griffiths et al., Australia. In Gene, 2012
examined the APOE epsilon4 allele, a known risk factor for Alzheimer's disease, and the COMT Val 158 polymorphism, previously implicated in schizophrenia, for association with lowered memory functioning in healthy adults
Sexual dimorphisms in the immune system of catechol-O-methyltransferase knockout mice.
Carlsten et al., Göteborg, Sweden. In Immunobiology, 2012
Data show that in male catechol-O-methyltransferase COMT(-/-)-mice, the total number of T-, and B-lymphocytes from spleen increased but the T-cell proliferative response decreased.
The catechol-O-methyltransferase Val(158)Met polymorphism modulates fronto-cortical dopamine turnover in early Parkinson's disease: a PET study.
Barker et al., London, United Kingdom. In Brain, 2012
The genotypic variation, COMT Val(158)Met, influences the fronto-striatal cognitive deficits of Parkinson's disease.
The impact of the catechol-O-methyltransferase genotype on vascular function and blood pressure after acute green tea ingestion.
Minihane et al., Reading, United Kingdom. In Mol Nutr Food Res, 2012
genetic association studies in male subjects in United Kingdom: investigation of whether an SNP in COMT (rs4680) might explain variations in effects of green tea extract as a dietary supplement on vascular function and blood pressure
[JSNP Excellent Presentation Award for AsCNP 2011: COMT Val 158 Met gene polymorphism influences the perception of other's pain].
Nomura et al., In Nihon Shinkei Seishin Yakurigaku Zasshi, 2012
COMT gene polymorphism affects pain sensitivity
Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.
CPNDS Consortium et al., Vancouver, Canada. In Nat Genet, 2009
the strong associations of cisplatin-induced hearing loss with specific genetic variants in COMT were identified
Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia.
Kalluri et al., Boston, United States. In Nature, 2008
pregnant mice deficient in catechol-O-methyltransferase (COMT) show a pre-eclampsia-like phenotype resulting from an absence of 2-methoxyoestradiol
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