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Contactin associated protein-like 5

CASPR5, CNTNAP5, Contactin-Associated Protein-Like 5
This gene product belongs to the neurexin family, members of which function in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, and thrombospondin N-terminal-like domains. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: TOP, fibrillin-1, contactin, OUT, DOCK4
Papers on CASPR5
Genome-wide characterization of circulating tumor cells identifies novel prognostic genomic alterations in systemic melanoma metastasis.
Hoon et al., Santa Monica, United States. In Clin Chem, 2014
CNTNAP5 (contactin associated protein-like 5), 2q14.3;
Genome-wide pharmacogenomic analysis of response to treatment with antipsychotics.
van den Oord et al., Richmond, United States. In Mol Psychiatry, 2011
In addition, SNPs in Ankyrin Repeat and Sterile Alpha Motif Domain-Containing Protein 1B (ANKS1B) and in the Contactin-Associated Protein-Like 5 gene (CNTNAP5), which mediated the effects of olanzapine and risperidone on Negative symptoms, were very close to our threshold for declaring significance.
Changes in whole blood gene expression in obese subjects with type 2 diabetes following bariatric surgery: a pilot study.
Smith et al., Cleveland, United States. In Plos One, 2010
Among the significantly regulated genes were GGT1, CAMP, DEFA1, LCN2, TP53, PDSS1, OLR1, CNTNAP5, DHCR24, HHAT and SARDH, which have been previously implicated in lipid metabolism, obesity and/or type 2 diabetes.
A genome-wide association study of bipolar disorder in Norwegian individuals, followed by replication in Icelandic sample.
Andreassen et al., Oslo, Norway. In J Affect Disord, 2010
The most significant markers were located in DLEU2, GUCY1B2, PKIA, CCL2, CNTNAP5, DPP10, and FBN1.
Characterization of a family with rare deletions in CNTNAP5 and DOCK4 suggests novel risk loci for autism and dyslexia.
International Molecular Genetic Study Of Autism Consortium et al., Oxford, United Kingdom. In Biol Psychiatry, 2010
Data suggest that rare variants in CNTNAP5 may confer autism spectrum disorder (ASD) susceptibility. Genomic disruption of both DOCK4 and CNTNAP5 genes may have an additive effect and may result in a more severe ASD phenotype.
Cytogenetic, FISH and array-CGH characterization of a complex chromosomal rearrangement carried by a mentally and language impaired patient.
Giardino et al., Milano, Italy. In Eur J Med Genet, 2009
Among deleted genes, particularly interesting seems to be CNTNAP5, encoding a member of the neurexin superfamily.
A mouse translocation associated with Caspr5-2 disruption and perinatal lethality.
Winking et al., Heidelberg, Germany. In Mamm Genome, 2008
We have previously described the paralogous mouse genes Caspr5-1, -2, and -3 of the neurexin gene family.
New members of the neurexin superfamily: multiple rodent homologues of the human CASPR5 gene.
Winking et al., L├╝beck, Germany. In Mamm Genome, 2006
We identified and, by in silico reconstruction, compiled three orthologues of the human CASPR5 gene from the mouse genome, four from the rat genome, and one each from the chimpanzee, dog, opossum, and chicken genomes.
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