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Contactin associated protein-like 4

Caspr4, CNTNAP4
This gene product belongs to the neurexin family, members of which function in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, and thrombospondin N-terminal-like domains. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: AGE, GAP, contactin, COL18A1, LNX2
Papers on Caspr4
High-dose folic acid supplementation alters the human sperm methylome and is influenced by the MTHFR C677T polymorphism.
Trasler et al., Montréal, Canada. In Hum Mol Genet, Dec 2015
Ingenuity Pathway Analysis revealed that methylation of promoter regions was altered in several genes involved in cancer and neurobehavioral disorders including CBFA2T3, PTPN6, COL18A1, ALDH2, UBE4B, ERBB2, GABRB3, CNTNAP4 and NIPA1.
Caspr4 interaction with LNX2 modulates the proliferation and neuronal differentiation of mouse neural progenitor cells.
Ma et al., Suzhou, China. In Stem Cells Dev, Apr 2015
Contactin-associated protein 4 (Caspr4), also known as contactin-associated protein-like protein (CNTNAP4), is expressed in various regions of the brain.
A common copy number variation polymorphism in the CNTNAP2 gene: sexual dimorphism in association with healthy aging and disease.
Puzianowska-Kuznicka et al., Mountain View, United States. In Gerontology, 2014
A new female-specific association with diseases and limited survival past 80 years was recently reported for a copy number variation (CNV) in the CNTNAP4 gene from the neurexin superfamily.
A common copy number variation (CNV) polymorphism in the CNTNAP4 gene: association with aging in females.
Puzianowska-Kuznicka et al., Vallejo, United States. In Plos One, 2012
RESULTS: In the discovery study of ≥80 vs.<80 years old seniors, a homozygous intronic CNV deletion in the CNTNAP4 gene was inversely associated with survival to the age of 80 (OR=0.51,
Genome-wide analysis of central corneal thickness in primary open-angle glaucoma cases in the NEIGHBOR and GLAUGEN consortia.
Hauser et al., Durham, United States. In Invest Ophthalmol Vis Sci, 2012
A quantitative analysis of central corneal thickness and a subsequent analysis of primary open-angle glaucoma (POAG), SNPs in two cell adhesion molecules, NTM and CNTNAP4, were identified and may increase POAG susceptibility in a subset of cases.
Genome-wide analysis identifies 16q deletion associated with survival, molecular subtypes, mRNA expression, and germline haplotypes in breast cancer patients.
Kristensen et al., Oslo, Norway. In Genes Chromosomes Cancer, 2008
3.5 MB downstream of the area most significantly associated with survival, and included the tumor suppressor gene ADAMTS18 and the cell recognition gene CNTNAP4.
Caspr3 and caspr4, two novel members of the caspr family are expressed in the nervous system and interact with PDZ domains.
Peles et al., Israel. In Mol Cell Neurosci, 2002
Here, we report the identification of Caspr3 and Caspr4, two new NCPs expressed in nervous system.
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