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Caspase 6, apoptosis-related cysteine peptidase

caspase-6, CASP6
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PrP, caspase-3, CAN, caspase-9, caspase-8
Papers using caspase-6 antibodies
Discovery of novel and potent small-molecule inhibitors of NO and cytokine production as antisepsis agents: synthesis and biological activity of alkyl 6-(N-substituted sulfamoyl)cyclohex-1-ene-1-carboxylate
Charlton Peter et al., In Critical Care, 2004
... Caspase-2 was purchased from Biomol (Exeter, UK), caspase-6 from BD Biosciences (Oxford, UK), caspase-9 from ...
Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors.
Nollen Ellen A. A., In PLoS ONE, 2001
... Antibodies recognizing IKKγ, IKKβ, caspase-3 and caspase 6 were purchased from Cell Signaling Technology (Danvers, MA) ...
Deficiency in caspase 9 or caspase 3 induces compensatory caspase activation
Dobson P R M et al., In British Journal of Cancer, 1999
... and the polyclonal antibody to caspase-6 were obtained from Santa Cruz Biotechnology Inc., (California, USA) ...
Caspase-dependent and -independent death of camptothecin-treated embryonic cortical neurons.
LeBlanc Andrea C., In PLoS ONE, 1998
... ab8982 and ab83472), antibody against full-length caspase-6 was from Cell Signaling Technology (cat ...
Papers on caspase-6
Evidence for caspase-dependent programmed cell death along with repair processes in affected skeletal muscle fibres in patients with mitochondrial disorders.
Tomelleri et al., Verona, Italy. In Clin Sci (lond), Mar 2016
We documented that in affected muscle fibres, nuclear chromatin is condensed in lumpy irregular masses and cytochrome c is released into the cytosol to activate, along with Apaf-1 (apoptotic protease-activating factor 1), caspase 9 that, in turn, activates effector caspase 3, caspase 6, and caspase 7, suggesting the execution of the intrinsic apoptotic pathway.
Vasculogenic mimicry: Possible role of effector caspase-3, caspase-6 and caspase-7.
Tschernig et al., Saarbrücken, Germany. In Ann Anat, Jan 2016
UNASSIGNED: Vasculogenic mimicry (VM) describes the process by which aggressive cancer cells form extracellular matrix-rich, vessel-like mesh works, which supply nutrients and oxygen.
Toxic effect of NiCl2 on development of the bursa of Fabricius in broiler chickens.
Guo et al., China. In Oncotarget, Jan 2016
Concurrently, the mRNA expression levels of bax, cytochrome c (cyt c), apoptotic peptidase activating factor 1 (Apaf-1), caspase-3, caspase-6, caspase-7 and caspase-9 were increased and the bcl-2 mRNA expression levels were decreased.
Molecular evidence of Zn chelation of the procaspase activating compound B-PAC-1 in B cell lymphoma.
Gandhi et al., Houston, United States. In Oncotarget, Jan 2016
Using caspase-6 and -9 exosite analysis, we identified and mutated predicted Zn-ligands in caspase-3 (H108A, C148S and E272A) and overexpressed into DKO MEFs.
Apoptotic and nonapoptotic function of caspase 7 in spermatogenesis.
Mao et al., Shenzhen, China. In Asian J Androl, Jan 2016
In addition, spermatogenic dysfunction induced by busulfan gradually enhanced the apoptosis and elevated the expression of caspase 3, caspase 6, and caspase 9, but decreased the expression of caspase 7 in spermatogenic cells.
[Role of long non-coding RNA BC088414 in hypoxic-ischemic injury of neural cells].
Mu et al., Chengdu, China. In Zhongguo Dang Dai Er Ke Za Zhi, Dec 2015
Quantitative real-time PCR was used to measure mRNA expression of lncRNA BC088414, β2-adrenoceptor (Adrb2), and caspase-6 (CASP6).
Targeting caspase-6 and caspase-8 to promote neuronal survival following ischemic stroke.
Koeberle et al., Toronto, Canada. In Cell Death Dis, 2014
Previous studies show that caspase-6 and caspase-8 are involved in neuronal apoptosis and regenerative failure after trauma of the adult central nervous system (CNS).
Activation and regulation of caspase-6 and its role in neurodegenerative diseases.
Su et al., Key West, United States. In Annu Rev Pharmacol Toxicol, 2014
Caspase-6 is classified as an apoptotic effector, and it mediates nuclear shrinkage during apoptosis, but it possesses unique activation and regulation mechanisms that differ from those of other effector caspases.
Down-regulation of nectin-4 inhibits apoptosis in systemic lupus erythematous (SLE) through targeting Bcl-2/Bax pathway.
Huang et al., Shanghai, China. In Int J Clin Exp Pathol, 2014
Moreover, nectin-4 down-regulation could significantly decrease Bcl-2, Bcl-XL, and caspase-6 expressions but increase Bax level in SLE group.
Inhibiting caspase-6 activation and catalytic activity for neurodegenerative diseases.
Arkin et al., San Francisco, United States. In Curr Top Med Chem, 2013
We describe the structure of the collaboration between the University of California - San Francisco - Small Molecule Discovery Center (UCSF-SMDC) and Genentech to develop chemical matter that inhibits the activity of caspase-6.
Modulating caspase activity: beyond the active site.
Renslo et al., San Francisco, United States. In Curr Opin Struct Biol, 2013
Surprising new examples of caspase modulation have also been described recently, including a small molecule that binds caspase-6-substrate complexes uncompetitively and a short peptide that stabilizes an inactive, tetrameric form of procaspase-6.
Caspase-6 as a novel early target in the treatment of Alzheimer's disease.
LeBlanc, Montréal, Canada. In Eur J Neurosci, 2013
Among many areas in development, an emphasis on the role of caspase-6 (Casp6) activity in early neurodegenerative mechanisms brings hope of a novel target against AD.
Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization.
Hannoush et al., San Francisco, United States. In Nat Chem Biol, 2012
peptide binds at a tetramerization interface that is uniquely present in zymogen caspase-6, rather than binding into the active site, and acts via a new allosteric mechanism that promotes caspase tetramerization
Caspase-6 activity in a BACHD mouse modulates steady-state levels of mutant huntingtin protein but is not necessary for production of a 586 amino acid proteolytic fragment.
Ellerby et al., Novato, United States. In J Neurosci, 2012
This study demonistrated that elimination of caspase-6 protein and activity in the BACHD mouse model does not prevent the production of a 586 aa Htt proteolytic fragment in the brain.
Inhibitory mechanism of caspase-6 phosphorylation revealed by crystal structures, molecular dynamics simulations, and biochemical assays.
Su et al., Beijing, China. In J Biol Chem, 2012
Results showed the inhibition mechanism of CASP6 phosphorylation and laid the foundation for a new strategy of rational CASP6 drug design.
Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice.
Hayden et al., Vancouver, Canada. In Hum Mol Genet, 2012
Casp6-/- neurons are protected against excitotoxicity, nerve growth factor deprivation and myelin-induced axonal degeneration. Furthermore, Casp6-deficient mice show an age-dependent increase in cortical and striatal volume.
The catalytic subunit of human telomerase is a unique caspase-6 and caspase-7 substrate.
Jarstfer et al., Chapel Hill, United States. In Biochemistry, 2011
Caspase-6 cleaves human TERT at residues E129 and D637 as part of the apoptosis pathway in cultured cells.
APP binds DR6 to trigger axon pruning and neuron death via distinct caspases.
Tessier-Lavigne et al., San Francisco, United States. In Nature, 2009
results indicate that APP and DR6 are components of a neuronal self-destruction pathway, and suggest that an extracellular fragment of APP, acting via DR6 and caspase 6, contributes to Alzheimer's disease
Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.
Hayden et al., Vancouver, Canada. In Cell, 2006
To determine whether caspase cleavage of htt is a key event in the neuronal dysfunction and selective neurodegeneration in HD, we generated YAC mice expressing caspase-3- and caspase-6-resistant mutant htt.
Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation.
Tsujimoto et al., Suita, Japan. In Nature, 1999
These changes are triggered by the activation of a family of cysteine proteases called caspases, and caspase-activated DNase (CAD/DFF40) and lamin protease (caspase-6) have been implicated in some of these changes.
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