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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Caspase 10, apoptosis-related cysteine peptidase

Caspase 10, CASP10
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011] (from NCBI)
Top mentioned proteins: PrP, caspase-8, CAN, caspase-3, bcl-2
Papers using Caspase 10 antibodies
Modulation of cellular apoptosis with apoptotic protease-activating factor 1 (apaf-1) inhibitors
Pérez-Payá E et al., In Cell Death & Disease, 2007
... Caspase-10 antibody (M059–3) was purchased from MBL (Woburn, MA, USA) and ...
Retroactive pathway involving mitochondria in electroloaded cytochrome c-induced apoptosis. Protective properties of Bcl-2 and Bcl-XL.
Rieux-Laucat Frederic, In PLoS ONE, 2002
... and anti-caspase-8 (clone B9-2; 0.5 µg/mL) antibodies were from BD Biosciences (Le Pont-de-Claix, France); monoclonal anti-caspase-10 (clone 4C1; 1 µg/mL) was from MBL (Meudon, France); polyclonal anti-caspase-3 ...
Papers on Caspase 10
Ferulic acid decreases cell viability and colony formation while inhibiting migration of MIA PaCa-2 human pancreatic cancer cells in vitro.
Seçme et al., Nicosia, Cyprus. In Gene, Feb 2016
Expression profiles of certain cell cycle and apoptosis genes such as CCND1 (cyclin D1),CDK4, CDK6, RB, p21, p16, p53, caspase-3, caspase-9, caspase-8, caspase-10, Bcl-2, BCL-XL,BID, DR4,DR5,FADD,TRADD,PARP, APAF, Bax, Akt, PTEN, PUMA, NOXA, MMP2, MMP9, TIMP1 and TIMP2 were determined by real-time PCR.
Repurposing L-Menthol for Systems Medicine and Cancer Therapeutics? L-Menthol Induces Apoptosis through Caspase 10 and by Suppressing HSP90.
Shasany et al., Lucknow, India. In Omics, Jan 2016
The microarray analysis identified caspase 10 as the important initiator caspase, instead of caspase 8.
Synergistic Myeloma Cell Death via Novel Intracellular Activation of Caspase-10-Dependent Apoptosis by Carfilzomib and Selinexor.
Jakubowiak et al., Poznań, Poland. In Mol Cancer Ther, Jan 2016
Investigating the details of SINE/PI-induced cell death revealed (i) reduced Bcl-2 expression and cleavage and inactivation of Akt, two prosurvival regulators of apoptosis and autophagy; (ii) intracellular membrane-associated aggregation of active caspases, which depended on caspase-10 protease activity; and (iii) novel association of caspase-10 and autophagy-associated proteins p62 and LC3 II, which may prime activation of the caspase cascade.
Exploiting Homology Information in Nontemplate Based Prediction of Protein Structures.
Tramontano et al., Roma, Italy. In J Chem Theory Comput, Nov 2015
We show that our results are competitive with respect to alternative methods, including those producing the best model for each of the analyzed targets in the CASP10 (10th Critical Assessment of techniques for protein Structure Prediction) experiment free modeling category.
Evolutionary analyses of caspase-8 and its paralogs: Deep origins of the apoptotic signaling pathways.
Miller et al., Kyoto, Japan. In Bioessays, Jul 2015
However, eutherians have lost caspase-18 and myomorph rodents have lost caspase-10, these losses suggesting functional redundancy amongst caspase-8 paralogs.
Polymorphisms in FAS and CASP8 genes may contribute to the development of ALPS phenotype: a study in 25 patients with probable ALPS.
Sanal et al., Ankara, Turkey. In Turk J Pediatr, Mar 2015
Germline and somatic FAS mutations, FASL and CASP10 mutations constitute other genetic defects in ALPS.
Updated Understanding of Autoimmune Lymphoproliferative Syndrome (ALPS).
Li et al., Nanchang, China. In Clin Rev Allergy Immunol, Mar 2015
In addition, other mutations of the genes such as Fas-ligand (FASLG), Caspase 10 (CASP10) and Caspase 8 (CASP8), NRAS and KRAS have also been observed in a small number of patients with ALPS or ALPS-related disorders.
Tandem DEDs and CARDs suggest novel mechanisms of signaling complex assembly.
Tung et al., Tainan City, Taiwan. In Apoptosis, Feb 2015
There are seven DED-containing proteins in human, including FADD, c-FLIP, caspase-8, caspase-10, DEDD, DEDD2, and PEA-15.
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
Slager et al., Bethesda, United States. In Nat Genet, 2013
In the meta-analysis, we identified ten independent associated SNPs in nine new loci at 10q23.31 (ACTA2 or FAS (ACTA2/FAS), P=1.22×10(-14)), 18q21.33 (BCL2, P=7.76×10(-11)), 11p15.5 (C11orf21, P=2.15×10(-10)), 4q25 (LEF1, P=4.24×10(-10)), 2q33.1 (CASP10 or CASP8 (CASP10/CASP8), P=2.50×10(-9)), 9p21.3 (CDKN2B-AS1, P=1.27×10(-8)), 18q21.32 (PMAIP1, P=2.51×10(-8)), 15q15.1 (BMF, P=2.71×10(-10)) and 2p22.2 (QPCT, P=1.68×10(-8)), as well as an independent signal at an established locus (2q13, ACOXL, P=2.08×10(-18)).
Control of autophagic cell death by caspase-10 in multiple myeloma.
Staudt et al., Bethesda, United States. In Cancer Cell, 2013
Unexpectedly, we discovered that all myeloma lines require caspase-10 for survival irrespective of their genetic abnormalities.
Autophagy in multiple myeloma: what makes you stronger can also kill you.
Martin et al., Dublin, Ireland. In Cancer Cell, 2013
However, in this issue of Cancer Cell, Lamy and colleagues report that multiple myeloma utilizes caspase-10 to restrain autophagy and undergoes autophagic cell death upon its removal or inhibition.
Antitumor function and mechanism of phycoerythrin from Porphyra haitanensis.
Liang et al., Shantou, China. In Biol Res, 2012
The QRT-PCR results showed that R-PE+PDT treatment increased caspase-3 and caspase-10 gene expression and decreased the Bcl-2 gene expression level significantly as the R-PE dose increased, implying that R-PE promoted HeLa cell apoptosis.
The protein factor-arrest 11 (Far11) is essential for the toxicity of human caspase-10 in yeast and participates in the regulation of autophagy and the DNA damage signaling.
Revuelta et al., Salamanca, Spain. In J Biol Chem, 2012
The protein factor-arrest 11 (Far11) is essential for the toxicity of human caspase-10 in yeast and participates in the regulation of autophagy and the DNA damage signaling.
Stoichiometry of the CD95 death-inducing signaling complex: experimental and modeling evidence for a death effector domain chain model.
Lavrik et al., Heidelberg, Germany. In Mol Cell, 2012
analysis of stoichiometry of the CD95 death-inducing signaling complex and demonstration of how procaspase-8, procaspase-10, and c-FLIP form DED chains at the DISC, enabling the formation of dimers and efficient activation of caspase-8
Apoptosis induced by avian H5N1 virus in human monocyte-derived macrophages involves TRAIL-inducing caspase-10 activation.
Utaisincharoen et al., Bangkok, Thailand. In Innate Immun, 2012
induces apoptosis in avian virus H5N1-infected human monocyte-derived macrophages
Downregulation of caspase-10 predicting poor survival after resection of stage II colorectal cancer.
Sun et al., Chengdu, China. In Int J Colorectal Dis, 2011
Caspase-10 expression, measured by quantitative real-time RT-PCR, is a possible prognostic factor in patients with stage II colorectal cancer.
Protein structure prediction: challenging targets for CASP10.
Runthala, Pilani, India. In J Biomol Struct Dyn, 2011
Functional characterization of proteins being one of the major issues in molecular biology is still unsolved due to several resource and technical limitations of experimental structure determination methods.
Concerted antigen processing of a short viral antigen by human caspase-5 and -10.
Del Val et al., Madrid, Spain. In J Biol Chem, 2011
analysis of concerted antigen processing of a short viral antigen by human caspase-5 and -10
Polymorphisms in the CASPASE genes and survival in patients with early-stage non-small-cell lung cancer.
Park et al., Taegu, South Korea. In J Clin Oncol, 2010
Nine potentially functional polymorphisms in the CASP3, CASP7, CASP8, CASP9, and CASP10 genes were investigated.
AK2 activates a novel apoptotic pathway through formation of a complex with FADD and caspase-10.
Jung et al., Kwangju, South Korea. In Nat Cell Biol, 2007
Here, we show that mitochondrial adenylate kinase 2 (AK2) mediates mitochondrial apoptosis through the formation of an AK2-FADD-caspase-10 (AFAC10) complex.
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