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Carnitine O-acetyltransferase

carnitine acetyltransferase, Carnitine O-Acetyltransferase, CAT
catalyzes the reversible transfer of an acyl group from acyl-CoA thioesters to carnitine; key enzyme in mitochondrial and endoplasmic reticulum metabolic pathways [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: catalase, SOD, ACID, CAN, Ros
Papers on carnitine acetyltransferase
Manganese superoxide dismutase, glutathione peroxidase and catalase gene polymorphisms and clinical outcomes in acute kidney injury.
Yilmaz et al., Isparta, Turkey. In Ren Fail, Feb 2016
UNASSIGNED: Introduction The aim of this study was to evaluate the potential association of single gene polymorphisms of manganese superoxide dismutase (MnSOD), glutathione peroxidase 1 (GPX1) and catalase (CAT) with clinical outcomes of acute kidney injury (AKI).
Moderate stress responses and specific changes in polyamine metabolism characterize Scots pine somatic embryogenesis.
Vuosku et al., Oulu, Finland. In Tree Physiol, Feb 2016
Cellular PA contents and the expression of the PA metabolism genes arginine decarboxylase (ADC), spermidine synthase (SPDS), thermospermine synthase (ACL5) and diamine oxidase (DAO) were analyzed, as well as the expression of catalase (CAT), DNA repair genes (RAD51, KU80) and autophagy-related genes (ATG5, ATG8) throughout the induction of somatic embryo formation in Scots pine SE cultures.
Immunoconjugates in the management of hairy cell leukemia.
Pastan et al., Bethesda, United States. In Best Pract Res Clin Haematol, Dec 2015
An affinity matured version of BL22, termed moxetumomab pasudotox (formerly HA22 or CAT-8015) achieved high CR rates in phase I, and is currently undergoing multicenter Phase 3 testing.
The Effect of Leonurus sibiricus Plant Extracts on Stimulating Repair and Protective Activity against Oxidative DNA Damage in CHO Cells and Content of Phenolic Compounds.
Śliwiński et al., Łódź, Poland. In Oxid Med Cell Longev, Dec 2015
Preincubation of the CHO cells with 0.5 mg/mL of plant extracts showed increased expression level of antioxidant genes (SOD2, CAT, and GPx).
Carnitine Acetyltransferase Mitigates Metabolic Inertia and Muscle Fatigue during Exercise.
Muoio et al., Durham, United States. In Cell Metab, Aug 2015
Short-chain carnitine conjugates, including acetylcarnitine, derive from their corresponding acyl-CoA precursors via the action of carnitine acetyltransferase (CrAT), a bidirectional mitochondrial matrix enzyme.
A review on effects of conjugated linoleic fatty acid (CLA) upon body composition and energetic metabolism.
Lehnen et al., Porto Alegre, Brazil. In J Int Soc Sports Nutr, 2014
CLA supplementation also could increase the lipolysis and reduce the accumulation of fatty acids on the adipose tissue; the putative mechanisms involved may be its action in reducing the lipase lipoprotein activity and to increase the carnitine-palmitoil-transferase-1 (CAT-1) activity, its interaction with PPARγ, and to raise the expression of UCP-1.
Marketing Regulatory Oversight of Advanced Therapy Medicinal Products (ATMPs) in Europe: The EMA/CAT Perspective.
Ferry et al., Helsinki, Finland. In Adv Exp Med Biol, 2014
Technical requirements for ATMPs are defined in the legislation, and guidance for different products is available through several EMA/CAT guidelines.
Physiological Roles of Hydrogen Sulfide and Polysulfides.
Kimura, Kodaira, Japan. In Handb Exp Pharmacol, 2014
H2S is produced from L-cysteine by cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3MST) together with cysteine aminotransferase (CAT).
Ascorbate Peroxidase and Catalase Activities and Their Genetic Regulation in Plants Subjected to Drought and Salinity Stresses.
Vitti et al., Potenza, Italy. In Int J Mol Sci, 2014
Plants are endowed with H2O2-metabolizing enzymes such as catalases (CAT), ascorbate peroxidases (APX), some peroxiredoxins, glutathione/thioredoxin peroxidases, and glutathione sulfo-transferases.
Antioxidant Potential of Plumieride against CCl₄-Induced Peroxidative Damage in Rats.
Gupta et al., Jaipur, India. In Antioxidants (basel), 2013
The antioxidant potential was evaluated by using hepatic tissue for SOD (superoxide dismutase), CAT (catalase), GSH (reduced glutathione), GPx (glutathione peroxidase), GR (glutathione reductase) and LPO (lipid peroxidation) alongwith the concomitant blood serum for AST & ALT (aspartate and alanine transaminases), GGT (gamma glutamyl transpeptidase), ALP (alkaline phosphatase), total bilirubin and total protein contents.
Syzyguim guineense Extracts Show Antioxidant Activities and Beneficial Activities on Oxidative Stress Induced by Ferric Chloride in the Liver Homogenate.
Ngogang et al., Yaoundé, Cameroon. In Antioxidants (basel), 2013
The oxidative damage inhibition in the liver was determined by measuring malondialdehyde (MDA) as well as the activity of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT) and peroxidase.
Chromatographic separation of reaction products from the choline acetyltransferase and carnitine acetyltransferase assay: differential ChAT and CrAT activity in brain extracts from Alzheimer's disease versus controls.
Lahiri et al., United States. In J Neurochem, 2012
this assay can be used to measure carnitine acetyltransferase activity in the same samples, and assays comparing choline O-acetyltransferase and CrAT show that carnitine acetyltransferase is highly active in neuronal tissues and in neuronal cell cultures
Structural basis for DNA damage-dependent poly(ADP-ribosyl)ation by human PARP-1.
Pascal et al., Philadelphia, United States. In Science, 2012
Here, we report the crystal structure of a DNA double-strand break in complex with human PARP-1 domains essential for activation (Zn1, Zn3, WGR-CAT).
Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility.
Mynatt et al., Durham, United States. In Cell Metab, 2012
Here, we identify an essential role for the mitochondrial matrix enzyme, carnitine acetyltransferase (CrAT), in regulating substrate switching and glucose tolerance.
Challenges with advanced therapy medicinal products and how to meet them.
Celis et al., In Nat Rev Drug Discov, 2010
Central to this framework is the Committee for Advanced Therapies (CAT) at the European Medicines Agency (EMA), comprising a multidisciplinary scientific expert committee, representing all EU member states and European Free Trade Association countries, as well as patient and medical associations.
The carnitine acetyltransferase gene (CRAT): a characterization of porcine transcripts with insights into the 5'-end variants of mammalian transcripts and their possible sub-cellular localization.
Milan et al., Toulouse, France. In Cell Mol Biol Lett, 2008
The predicted full length cDNA sequence of the porcine CRAT gene was characterised and a new 5' variant for dog, rat and mouse was proposed.
Mutagenesis of specific amino acids converts carnitine acetyltransferase into carnitine palmitoyltransferase.
Hegardt et al., Barcelona, Spain. In Biochemistry, 2006
by performing two amino acid replacements a carnitine acetyltransferase can be converted into a pseudo carnitine palmitoyltransferase in terms of substrate specificity
Redesign of carnitine acetyltransferase specificity by protein engineering.
Serra et al., Barcelona, Spain. In J Biol Chem, 2004
show for the first time that a single amino acid is able to determine the substrate specificity of carnitine acetyltransferase (CrAT)
Bacterial gene inserted in an engineered RNA virus: efficient expression in monocotyledonous plant cells.
Ahlquist et al., In Science, 1986
Variants of BMV RNA3 were constructed in which the coat gene had been removed or replaced with sequences encoding chloramphenicol acetyltransferase (CAT).
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