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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

CDKN2A interacting protein

CARF, collaborator of ARF
Top mentioned proteins: p53, p16, mdm2, Brain-derived neurotrophic factor, p21
Papers on CARF
Structural basis for the endoribonuclease activity of the type III-A CRISPR-associated protein Csm6.
Jinek et al., Zürich, Switzerland. In Rna, Feb 2016
The structure reveals a dimeric architecture generated by interactions involving the N-terminal CARF and C-terminal HEPN domains.
Recognition of a Pseudo-Symmetric RNA Tetranucleotide by Csx3, a New Member of the CRISPR Associated Rossmann Fold Superfamily.
Lawrence et al., Bozeman, United States. In Rna Biol, Feb 2016
Tertiary and quaternary structural similarities of Csx3 to CRISPR/Cas proteins Csx1 and Csa3 are identified and suggest Csx3 is a new member of the CRISPR Associated Rossmann Fold (CARF) superfamily.
Collaborator of alternative reading frame protein (CARF) regulates early processing of pre-ribosomal RNA by retaining XRN2 (5'-3' exoribonuclease) in the nucleoplasm.
Takahashi et al., Tokyo, Japan. In Nucleic Acids Res, Jan 2016
Collaborator of alternative reading frame protein (CARF) associates directly with ARF, p53, and/or human double minute 2 protein (HDM2), a ubiquitin-protein ligase, without cofactors and regulates cell proliferation by forming a negative feedback loop.
CARF (Collaborator of ARF) overexpression in p53-deficient cells promotes carcinogenesis.
Wadhwa et al., Tsukuba, Japan. In Mol Oncol, Nov 2015
Collaborator of ARF (CARF), initially identified as a binding partner of ARF (Alternate Reading Frame), has been shown to activate ARF-p53 pathway by multiple ways including stabilization of ARF and p53 tumor suppressor proteins, and transcriptional repression of a p53 antagonist, HDM2.
Review of Theoretical Prediction Models for Organic Extract Metabolites, Effect of Drying Temperature on Smooth Muscle Relaxing Activity Induced by Organic Extracts Specially Cecropia Obtusifolia Portal and Web Server Predictors of Drug-Protein Interaction.
Prado-Prado et al., Playa del Carmen, Mexico. In Mini Rev Med Chem, Mar 2015
Finally, relaxant activity of vascular smooth muscle is increased by 70ºC and reducing ability by the method of CARF increases with temperature.
Core and region-enriched networks of behaviorally regulated genes and the singing genome.
Jarvis et al., Durham, United States. In Science, 2015
RNA interference manipulations validated the role of the calcium-response transcription factor (CaRF) in regulating genes preferentially expressed in specific song nuclei in response to singing.
Risk factors and biomarkers of life-threatening cancers.
Autier, Lyon, France. In Ecancermedicalscience, 2014
Knowledge of cancer aggressiveness risk factors (CARF) may help in identifying subjects at high risk of developing a potentially deadly cancer (and not just any cancer).
Collaborator of ARF (CARF) regulates proliferative fate of human cells by dose-dependent regulation of DNA damage signaling.
Wadhwa et al., Tsukuba, Japan. In J Biol Chem, 2014
Collaborator of ARF (CARF) has been shown to directly bind to and regulate p53, a central protein that controls tumor suppression via cellular senescence and apoptosis.
Molecular characterization of collaborator of ARF (CARF) as a DNA damage response and cell cycle checkpoint regulatory protein.
Wadhwa et al., Tsukuba, Japan. In Exp Cell Res, 2014
CARF is an ARF-binding protein that has been shown to regulate the p53-p21-HDM2 pathway.
PAXT-1 promotes XRN2 activity by stabilizing it through a conserved domain.
Großhans et al., Basel, Switzerland. In Mol Cell, 2014
This domain occurs in additional metazoan proteins and mediates interaction of human CDKN2AIP/CARF and NKRF/NRF with XRN2.
CARF and WYL domains: ligand-binding regulators of prokaryotic defense systems.
Aravind et al., Bethesda, United States. In Front Genet, 2013
Here we comprehensively analyze sequences, structures and genomic neighborhoods of one of the most widespread groups of such genes that encode proteins containing a predicted nucleotide-binding domain with a Rossmann-like fold, which we denote CARF (CRISPR-associated Rossmann fold).
Analysis of indel variations in the human disease-associated genes CDKN2AIP, WDR66, USP20 and OR7C2 in a Korean population.
Park et al., Taejŏn, South Korea. In J Genet, 2011
Analysis of indel variations in the human disease-associated genes CDKN2AIP, WDR66, USP20 and OR7C2 in a Korean population.
Biological functions and transcriptional targets of CaRF in neurons.
West, Durham, United States. In Cell Calcium, 2011
Calcium-response factor (CaRF) is a unique DNA-binding protein first recognized as a transcription factor for its role in modulating transcription of the gene encoding Brain-Derived Neurotrophic Factor (BDNF) in neurons.
Molecular characterization of apoptosis induced by CARF silencing in human cancer cells.
Wadhwa et al., Tsukuba, Japan. In Cell Death Differ, 2011
CARF knockdown elicited DNA damage response as evidenced by increased levels of phosphorylated ATM and gammaH2AX, leading to induction of mitotic arrest and eventual apoptosis.
Reduced cortical BDNF expression and aberrant memory in Carf knock-out mice.
West et al., Durham, United States. In J Neurosci, 2010
the data of this study reveal novel roles for CaRF in the organization and/or function of neural circuits that underlie essential aspects of learning and memory.
Molecular bridging of aging and cancer: A CARF link.
Wadhwa et al., Ibaraki, Japan. In Ann N Y Acad Sci, 2010
Collaborator of ARF (CARF) was first cloned as an ARF partner in yeast two-hybrid screens.
Genome-wide identification of calcium-response factor (CaRF) binding sites predicts a role in regulation of neuronal signaling pathways.
West et al., Durham, United States. In Plos One, 2009
These data strongly support the characterization of CaRF as a unique transcription factor and provide the first insight into the program of CaRF-regulated transcription in neurons.
CARF Is a vital dual regulator of cellular senescence and apoptosis.
Wadhwa et al., Tsukuba, Japan. In J Biol Chem, 2009
CARF plays a dual role in regulating p53-mediated senescence and apoptosis, the two major tumor suppressor mechanisms.
CARF: an emerging regulator of p53 tumor suppressor and senescence pathway.
Wadhwa et al., Tsukuba, Japan. In Mech Ageing Dev, 2009
CARF may act as a novel key regulator of the p53 pathway at multiple checkpoints
CARF regulates p19ARF-p53-p21WAF1 senescence pathway by multiple checkpoints.
Wadhwa et al., Tsukuba, Japan. In Ann N Y Acad Sci, 2006
CARF was first cloned as a novel binding partner of ARF from a yeast-interactive screen.
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