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Carboxypeptidase B1

carboxypeptidase B, procarboxypeptidase B
Three different procarboxypeptidases A and two different procarboxypeptidases B have been isolated. The B1 and B2 forms differ from each other mainly in isoelectric point. Carboxypeptidase B1 is a highly tissue-specific protein and is a useful serum marker for acute pancreatitis and dysfunction of pancreatic transplants. It is not elevated in pancreatic carcinoma. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: carboxypeptidase, ACID, Trypsin, CAN, Plasminogen
Papers on carboxypeptidase B
Evaluation of employing poly-lysine tags versus poly-histidine tags for purification and characterization of recombinant copper-binding proteins.
Xiao et al., Melbourne, Australia. In J Inorg Biochem, Jan 2016
The tag may be removed readily by the enzyme carboxypeptidase B to generate the native protein with no extra residues.
Active Compounds Against Anopheles minimus Carboxypeptidase B for Malaria Transmission-Blocking Strategy.
Kubera et al., Bangkok, Thailand. In J Med Entomol, Nov 2015
Carboxypeptidase B (CPB) in the midgut of Anopheline mosquitoes has been demonstrated to be essential for the sexual development of Plasmodium in the mosquito.
Selective modulation of thrombin-activatable fibrinolysis inhibitor (TAFI) activation by thrombin or the thrombin-thrombomodulin complex using TAFI-derived peptides.
Meijers et al., Amsterdam, Netherlands. In J Thromb Haemost, Nov 2015
The inhibition was TAFIa specific, because no effect on the homologous enzyme carboxypeptidase B was observed.
Structure of the complex of carboxypeptidase B and N-sulfamoyl-L-arginine.
Kuranova et al., Moscow, Russia. In Acta Crystallogr Sect F Struct Biol Commun, Oct 2015
Porcine pancreatic carboxypeptidase B (EC was complexed with a stable transition-state analogue, N-sulfamoyl-L-arginine, in which an S atom imitates the sp(3)-hybridized carbon in the scissile-bond surrogate.
PI3-Kinase Inhibitor LY294002 Repressed the Expression of Thrombin-Activatable Fibrinolysis Inhibitor in Human Hepatoma HepG2 Cells.
Takada et al., In Biol Pharm Bull, 2014
Thrombin-activatable fibrinolysis inhibitor (TAFI) is a carboxypeptidase B-like proenzyme biosynthesized in the liver and released into the blood circulation.
Laboratory diagnosis of acute pancreatitis: in search of the Holy Grail.
Cervellin et al., Parma, Italy. In Crit Rev Clin Lab Sci, 2012
Some interesting biomarkers have been also suggested (e.g., serum and urinary trypsinogen-1, -2 and -3, phospholipase A2, pancreatic elastase, procalcitonin, trypsinogen activated protein, activation peptide of carboxypeptidase B, trypsin-2-alpha1 antitrypsin complex and circulating DNA), but none of them has found widespread application for a variety of reasons, including the inferior diagnostic accuracy when compared with the traditional enzymes, the use of cumbersome techniques, or their recent discovery.
The plasminogen receptor, Plg-R(KT), and macrophage function.
Parmer et al., Los Angeles, United States. In J Biomed Biotechnol, 2011
We have used a proteomics approach combining targeted proteolysis with carboxypeptidase B and multidimensional protein identification technology, MudPIT, and a monocyte progenitor cell line to identify a novel transmembrane protein, the plasminogen receptor, Plg-R(KT).
On the discovery of precursor processing.
Steiner, Chicago, United States. In Methods Mol Biol, 2010
The subsequent discovery of a similar biosynthetic pathway in yeast led to the identification of eukaryotic families of specialized processing subtilisin-like endopeptidases coupled with carboxypeptidase B-like exopeptidases.
Progress in metallocarboxypeptidases and their small molecular weight inhibitors.
Avil├ęs et al., Barcelona, Spain. In Biochimie, 2010
Plasma carboxypeptidase B is a biological target for therapy because of its involvement in the coagulation/fibrinolysis processes.
Thrombomodulin mutations in atypical hemolytic-uremic syndrome.
Conway et al., Leuven, Belgium. In N Engl J Med, 2009
By promoting activation of the plasma procarboxypeptidase B, thrombomodulin also accelerates the inactivation of anaphylatoxins C3a and C5a.
The NMR structure and dynamics of the two-domain tick carboxypeptidase inhibitor reveal flexibility in its free form and stiffness upon binding to human carboxypeptidase B.
Blanco et al., Madrid, Spain. In Biochemistry, 2008
The structure of the tick carboxypeptidase inhibitor (TCI) and its backbone dynamics, free and in complex with human carboxypeptidase B, have been determined by NMR spectroscopy.
TAFI and pancreatic carboxypeptidase B modulate in vitro capillary tube formation by human microvascular endothelial cells.
Rijken et al., Amsterdam, Netherlands. In Arterioscler Thromb Vasc Biol, 2007
TAFI and CPB modulate the plasminogen system both in the matrix and on the cell surface, thus leading to the inhibition of endothelial cell movement and tube formation.
[Role of carboxypeptidase in regulation of fibrinolysis].
Kudinov et al., In Ukr Biokhim Zh (1999), 2004
Data are cited about carboxypeptidase B level changes under different physiological conditions and possible methods of fibrinolysis reactions strengthening by means of influence on activity of that carboxypeptidase.
Genetic determinants of diastolic and pulse pressure map to different loci in Lyon hypertensive rats.
Sassard et al., Paris, France. In Nat Genet, 1993
Significant linkage was established between diastolic blood pressure and a microsatellite marker of the renin gene (REN) on rat chromosome 13, and between pulse pressure and the carboxypeptidase B gene (CPB) on chromosome 2.
Yeast KEX1 gene encodes a putative protease with a carboxypeptidase B-like function involved in killer toxin and alpha-factor precursor processing.
Bussey et al., In Cell, 1987
The yeast KEX1 gene product has homology to yeast carboxypeptidase Y.
Glycyl glutamine, an inhibitory neuropeptide derived from beta-endorphin.
Wolstencroft et al., In Nature, 1983
These derivatives of beta-endorphin are released by an endopeptidase that appears to catalyse cleavage on the carboxyl side of paired lysine residues, followed by the action of a carboxypeptidase B-like enzyme (Fig. 1).
An about 50,000-dalton protein in adrenal medulla: a common precursor of [Met]- and [Leu]enkephalin.
Udenfriend et al., In Science, 1980
Digestion with trypsin and carboxypeptidase B yields [Met]enkephalin and [Leu]enkephalin in a ratio of almost 7 to 1.
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