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Carbonic anhydrase IX

carbonic anhydrase IX, CA IX, G250, Ca9, carbonic anhydrase 9
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and the only tumor-associated carbonic anhydrase isoenzyme known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, vascular endothelial growth factor, HIF-1alpha, XRCC1
Papers using carbonic anhydrase IX antibodies
Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML.
McCubrey James, In PLoS ONE, 2008
... Inc), anti-CD45 (Cell Signaling Technology), anti-CD22 (Novocastra), anti-CXCR4 (Abcam), anti-SDF-1α, anti-CD31 (Santa Cruz Biotechnology) and anti-CAIX (Novus Biologicals).
Notch signaling: from the outside in
van Diest Paul J. et al., In Cellular Oncology (Dordrecht), 1999
Peritoneal metastatic model for human scirrhous gastric carcinoma in nude mice
Hirakawa K et al., In British Journal of Cancer, 1995
... The tissue sections were subjected to immunohistochemical staining using antibodies against carbonic anhydrase 9 (CA9; 1 : 1000; Novus Biologicals, Littleton, CO, USA), and ...
Papers on carbonic anhydrase IX
Estrogen and progesterone differentially regulate carbonic anhydrase II, III, IX, XII, and XIII in ovariectomized rat uteri.
Salleh et al., Kuala Lumpur, Malaysia. In Syst Biol Reprod Med, Feb 2016
The levels of CAII, III, XII, and XIII mRNAs and proteins were elevated while levels of CAIX mRNA and protein were reduced following progesterone-only and estrogen plus progesterone treatment, compared to the control and estrogen plus vehicle, respectively.
Renal Neoplasms With Overlapping Features of Clear Cell Renal Cell Carcinoma and Clear Cell Papillary Renal Cell Carcinoma: A Clinicopathologic Study of 37 Cases From a Single Institution.
Przybycin et al., Cleveland, United States. In Am J Surg Pathol, Feb 2016
CD10, α-methylacyl-CoA-racemase, high-molecular-weight cytokeratin, and carbonic anhydrase IX (CA IX) had no significant differential expression between these foci.
Development of certain new 2-substituted-quinazolin-4-yl-aminobenzenesulfonamide as potential antitumor agents.
Supuran et al., Portugal. In Eur J Med Chem, Feb 2016
CA IX is overexpressed in colorectal cancer specifically in hereditary nonpolyposis colorectal cancer.
Phase 2 Study of Lutetium 177-Labeled Anti-Carbonic Anhydrase IX Monoclonal Antibody Girentuximab in Patients with Advanced Renal Cell Carcinoma.
Mulders et al., Nijmegen, Netherlands. In Eur Urol, Jan 2016
UNASSIGNED: Despite advances in the treatment of metastatic clear cell renal cell carcinoma (ccRCC), there is still an unmet need in the treatment of this disease.
Hypoxia-Associated Marker CA IX Does Not Predict the Response of Locally Advanced Rectal Cancers to Neoadjuvant Chemoradiotherapy.
Schmidberger et al., Mainz, Germany. In Adv Exp Med Biol, Dec 2015
A total of 29 pretreatment biopsy specimens were stained for CA IX by immunohistochemistry, converted to digital images and evaluated in a quantitative fashion using image analysis software.
MiT Family Translocation-Associated Renal Cell Carcinoma: A Contemporary Update With Emphasis on Morphologic, Immunophenotypic, and Molecular Mimics.
Mehra et al., Ann Arbor, United States. In Arch Pathol Lab Med, Oct 2015
Directed ancillary testing is an essential aspect to the workup of t-RCC cases and may include a panel of immunohistochemical stains, such as PAX8, pancytokeratins, epithelial membrane antigen, carbonic anhydrase IX, HMB-45, and Melan-A.
New ways to image and target tumour hypoxia and its molecular responses.
Lambin et al., Maastricht, Netherlands. In Radiother Oncol, Sep 2015
Furthermore, recent progress made in targeting hypoxia (hypoxia-activated prodrugs) or hypoxia response (carbonic anhydrase IX inhibitors) is summarized.
Dual-display of small molecules enables the discovery of ligand pairs and facilitates affinity maturation.
Scheuermann et al., Zürich, Switzerland. In Nat Chem, Mar 2015
Using this approach we report the discovery of a low micromolar binder to alpha-1-acid glycoprotein and the affinity maturation of a ligand to carbonic anhydrase IX, an established marker of renal cell carcinoma.
Molecular and immunologic markers of kidney cancer-potential applications in predictive, preventive and personalized medicine.
Gratchev et al., Mannheim, Germany. In Epma J, 2014
The most common molecular markers of kidney cancer include mutations and epigenetic inactivation of von Hippel-Lindau (VHL) gene, genes of vascular endothelial growth factor (VEGF) pathway, and carbonic anhydrase IX (CIAX).
Carbonic anhydrase IX inhibitors in cancer therapy: an update.
Winum et al., Sesto Fiorentino, Italy. In Future Med Chem, 2014
These enzymes are of clinical relevance in cancer therapy as among the 15 isoforms known in humans, two cell surface CA isoforms, namely CA IX (almost exclusively associated with tumors) and CA XII (overexpressed in some tumor types) are involved in tumorigenesis.
Exploring Different Strategies for Efficient Delivery of Colorectal Cancer Therapy.
Yang et al., Hong Kong, Hong Kong. In Int J Mol Sci, 2014
On the other hand, systemic drug delivery strategies to specific molecular targets (such as FGFR, EGFR, CD44, EpCAM, CA IX, PPARγ and COX-2) overexpressed by cancerous cells have also been shown to be effective.
Phosphorylation of signal transducer and activator of transcription 3 (STAT3) correlates with Her-2 status, carbonic anhydrase 9 expression and prognosis in esophageal cancer.
Birner et al., Vienna, Austria. In Clin Exp Metastasis, 2012
Expression of pSTAT3 correlates with Her-2 status and CAIX expression and is associated with tumor progression and worse outcome in esophageal cancer
Main effects and interactions of carbonic anhydrase IX, hypoxia-inducible factor-1α, ezrin and glucose transporter-1 in multivariate analysis for disease outcome in rectal cancer.
Syrjänen et al., Turku, Finland. In Anticancer Res, 2012
panel consisting of moderate/strong expression of CA IX, positive HIF-1alpha expression and negative/weak GLUT-1 expression in operative samples and negative/weak ezrin expression in biopsies was associated with 47.5-fold risk of death from this disease
Dickkopf-1 (DKK-1) interrupts FAK/PI3K/mTOR pathway by interaction of carbonic anhydrase IX (CA9) in tumorigenesis.
Rho et al., South Korea. In Cell Signal, 2012
these findings identify DKK-1 as a potential factor in the regulation of CA9(carbonic anhydrase IX) cellular homeostasis and also suggest a new possible role for DKK1-1 in tumorigenesis
Co-expression of VEGF and CA9 in ovarian high-grade serous carcinoma and relationship to survival.
Deen et al., Nottingham, United Kingdom. In Virchows Arch, 2012
The combined high expression CA9 and VEGF phenotypewas significantly associated with increased resistance to chemotherapy and poor overall survival in ovarian high-grade serous carcinoma
Role of zinc in catalytic activity of carbonic anhydrase IX.
Frost et al., Gainesville, United States. In Arch Biochem Biophys, 2012
MDA-MB-231 breast cancer cells express CAIX in response to hypoxia. We compared CAIX activity associated with membrane ghosts isolated from hypoxic cells with that in intact hypoxic cells.
Presence of intratumoral neutrophils is an independent prognostic factor in localized renal cell carcinoma.
von der Maase et al., Århus, Denmark. In J Clin Oncol, 2009
Biomarkers (intratumoral CD8+, CD57+ immune cells, CD66b+ neutrophils, and carbonic anhydrase IX [CA IX]) were assessed by immunohistochemistry, and the relationship with clinical and histopathologic features and patient outcome was evaluated.
Randomized phase II study comparing two schedules of everolimus in patients with recurrent/metastatic breast cancer: NCIC Clinical Trials Group IND.163.
Seymour et al., Kelowna, Canada. In J Clin Oncol, 2009
pAKT, PTEN, carbonic anhydrase 9, estrogen receptor (ER), progesterone receptor, and human epidermal growth factor receptor 2 (HER2) were evaluated for possible correlation with response.
Tumor angiogenic and hypoxic profiles predict radiographic response and survival in malignant astrocytoma patients treated with bevacizumab and irinotecan.
Rich et al., Durham, United States. In J Clin Oncol, 2008
VEGF, VEGF receptor-2, CD31, hypoxia-inducible carbonic anhydrase 9 (CA9), and hypoxia-inducible factor-2alpha were semiquantitatively assessed by immunohistochemistry. Radiographic response and survival outcomes were correlated with these angiogenic and hypoxic markers.
Carbonic anhydrase IX is not an independent predictor of outcome for patients with clear cell renal cell carcinoma.
Kwon et al., Rochester, United States. In J Clin Oncol, 2007
PURPOSE: Expression of carbonic anhydrase IX (CAIX) has been reported to be an independent predictor of outcome and is being investigated as a therapeutic target for patients with clear cell renal cell carcinoma (ccRCC).
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