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RAS p21 protein activator 4

This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, SET, HAD, OUT, TOP
Papers on CAPRI
Identification of Protein-Protein Interactions by Detecting Correlated Mutation at the Interface.
Tang et al., Tianjin, China. In J Chem Inf Model, Oct 2015
Our method has overall accuracy and coverage values of 59% and 63% on Benchmark v4.0, and 50% and 49% on CAPRI targets.
CAPRI: efficient inference of cancer progression models from cross-sectional data.
Mishra et al., New York City, United States. In Bioinformatics, Oct 2015
Our empirical analysis of the accuracy and convergence rate of our algorithm, CAncer PRogression Inference (CAPRI), shows that it outperforms the state-of-the-art algorithms addressing similar problems.
The hypertension of Cushing's syndrome: controversies in the pathophysiology and focus on cardiovascular complications.
ABC Study Group et al., Milano, Italy. In J Hypertens, 2015
This review, developed during the first 'Altogether to Beat Cushing's syndrome' workshop held in Capri in 2012, evaluates the most important peculiarities of hypertension associated with CS, with a particular focus on its pathophysiology.
New records of Lophoproctuscoecus Pocock, 1894 (Diplopoda, Polyxenida, Lophoproctidae) extend the range of the genus Lophoproctus.
Short, Melbourne, Australia. In Zookeys, 2014
Lophoproctus specimens collected in Italy by Verhoeff were reassigned as Lophoproctuscoecus with the exception of one specimen of Lophoproctusjeanneli (Brölemann, 1910) from Capri.
PPCheck: A Webserver for the Quantitative Analysis of Protein-Protein Interfaces and Prediction of Residue Hotspots.
Sowdhamini et al., Bengaluru, India. In Bioinform Biol Insights, 2014
PPCheck, along with conservation and accessibility scores, was able to differentiate 'native-like and non-native-like poses from 1883 decoys of Critical Assessment of Prediction of Interactions (CAPRI) targets with an accuracy of 60%.
Structural neighboring property for identifying protein-protein binding sites.
Wang et al., In Bmc Syst Biol, 2014
On the CAPRI targets, our method has average I(rmsd) value of 3.46 Å and overall F(nat) value of 45%, which improves upon I(rmsd) of 4.18 Å and F(nat) of 40% for ZRANK, and I(rmsd) of 5.12 Å and F(nat) of 32% for ClusPro.
Benefits of a continuous therapy for cancer patients with a novel adoptive cell therapy by cascade priming (CAPRI).
Laumbacher et al., München, Germany. In Immunotherapy, 2013
A growing body of evidence shows that immune cells are pivotal in the fight against cancer.
Sampling and scoring: a marriage made in heaven.
Kozakov et al., Boston, United States. In Proteins, 2013
Although some of the examples are based on our own experience, the results of the CAPRI docking and scoring experiments also show that performing both sampling and scoring generally yields better results than scoring the structures generated by all predictors.
Protein-Protein Docking Using EMAP in CHARMM and Support Vector Machine: Application to Ab/Ag Complexes.
Lim et al., Taipei, Taiwan. In J Chem Theory Comput, 2013
Tests on 24 Ab/Ag complexes from the protein-protein docking benchmark version 3.0 showed that based on CAPRI evaluation criteria, EMAP could generate medium-quality native conformations in each case.
Protein-protein docking and hot-spot prediction for drug discovery.
Fernández-Recio et al., Barcelona, Spain. In Curr Pharm Des, 2011
Docking algorithms can achieve successful predictive rates in many complexes, as shown in the community assessment experiment CAPRI, and have already been applied to a variety of cases of biomedical interest.
Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities.
Lockyer et al., Cambridge, United Kingdom. In J Biol Chem, 2011
Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities
Protein-protein docking tested in blind predictions: the CAPRI experiment.
Janin, Orsay, France. In Mol Biosyst, 2010
CAPRI (Critical Assessment of PRedicted Interactions) is a community-wide experiment set up to monitor progress in the field.
Identification of an alternatively spliced variant of Ca2+-promoted Ras inactivator as a possible regulator of RANKL shedding.
Tanaka et al., Tokyo, Japan. In J Biol Chem, 2006
deltaCAPRI regulates RANKL shedding by modulating MMP14 expression through Ras signaling cascades other than the Erk pathway
An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis.
He et al., Durham, United States. In Nat Immunol, 2005
Here we show that the calcium-promoted Ras inactivator (CAPRI), a Ras GTPase-activating protein, functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis.
CAPRI and RASAL impose different modes of information processing on Ras due to contrasting temporal filtering of Ca2+.
Lockyer et al., Cambridge, United Kingdom. In J Cell Biol, 2005
CAPRI seems to low-pass filter the Ca2+ signal, converting different intensities of stimulation into different durations of Ras activity.
Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1.
Philips et al., New York City, United States. In Nature, 2003
Whereas Ca(2+) positively regulated Ras on the Golgi apparatus through RasGRP1, the same second messenger negatively regulated Ras on the plasma membrane by means of the Ras GTPase-activating protein CAPRI.
CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway.
Cullen et al., Bristol, United Kingdom. In Curr Biol, 2001
CAPRI (Ca2+-promoted Ras inactivator) a Ca2+-dependent Ras GTPase-activating protein (Ras GAP). Switches off the Ras-MAPK pathway following G protein-coupled receptor stimulated intracellular Ca2+ elevation that recruits CAPRI to the plasma membrane.
Search for the viking 2 landing site.
Crabill et al., In Science, 1976
Seven times as much area (4.5 million square kilometers) was examined as for Viking 1. Cydonia (B1) and Capri (C1) sites were examined with the Viking 1 orbiter.
Preliminary results from the viking orbiter imaging experiment.
Wellman et al., In Science, 1976
Most were of potential landing sites in Chryse Planitia and Cydonia and near Capri Chasma.
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