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Calpain 11

CAPN11, Calpain 11, Calcium dependent thiol protease
Calpains constitute a family of intracellular calcium-dependent cysteine proteases. There are eight members in this superfamily. They consist of a variable 80 kDa subunit and an invariant 30 kDa subunit. This calpain protein appears to have protease activity and calcium-binding ability. A similar mouse protein may play a functional role in spermatogenesis and in the regulation of calcium-dependent signal transduction events during meiosis. [provided by RefSeq, Dec 2008] (from NCBI)
Top mentioned proteins: Calpain, mu-Cl, calpain 2, HAD, SET
Papers on CAPN11
Characterization of the definitive classical calpain family of vertebrates using phylogenetic, evolutionary and expression analyses.
Wilcox et al., Aberdeen, United Kingdom. In Open Biol, 2013
We demonstrate that the common vertebrate ancestor had at least six classical calpains, including a single gene that gave rise to CAPN11, 1, 2 and 8 in the early jawed fish lineage, plus CAPN3, 9, 12, 13 and a novel calpain gene, hereafter named CAPN17.
Potential biomarkers of nonobstructive azoospermia identified in microarray gene expression analysis.
Kurpisz et al., PoznaƄ, Poland. In Fertil Steril, 2013
AKAP4, UBQLN3, CAPN11, GGN, SPACA4, SPATA3, and FAM71F1 were the most significantly down-regulated genes in infertile patients.
A newly classified vertebrate calpain protease, directly ancestral to CAPN1 and 2, episodically evolved a restricted physiological function in placental mammals.
Johnston et al., Saint Andrews, United Kingdom. In Mol Biol Evol, 2010
Here, we establish that mu/m-CAPN shares one-to-one orthology with CAPN11, previously described only in eutherians (placental mammals).
Characterisation of capn1, capn2-like, capn3 and capn11 genes in Atlantic halibut (Hippoglossus hippoglossus L.): Transcriptional regulation across tissues and in skeletal muscle at distinct nutritional states.
Johnston et al., Saint Andrews, United Kingdom. In Gene, 2010
Here we characterised Atlantic halibut complete-coding orthologues of calpain-1, calpain-2-like, "muscle-specific" calpain-3, plus calpain-11, a recently recognised vertebrate-wide family member.
Calpain 11 is unique to mouse spermatogenic cells.
Eddy et al., Tel Aviv-Yafo, Israel. In Mol Reprod Dev, 2006
Characterization of a related mouse gene and comparison of the protein to the human protein.
Calpain-cleaved collapsin response mediator protein-3 induces neuronal death after glutamate toxicity and cerebral ischemia.
Kappler et al., Ottawa, Canada. In J Neurosci, 2006
Collectively, these results reveal a novel role of CRMP-3 in that calpain cleavage of CRMP-3 and the subsequent nuclear translocation of the truncated CRMP-3 evokes neuronal death in response to excitotoxicity and cerebral ischemia.
Both the conserved and the unique gene structure of stomach-specific calpains reveal processes of calpain gene evolution.
Suzuki et al., Tokyo, Japan. In J Mol Evol, 2001
Capn8 shows the highly conserved gene organization of the other typical calpain large subunit genes, CAPN1, CAPN2, CAPN3, CAPN9, CAPN11, and Capn12, except for the unique exon between exon 9 and exon 10 of Capn8, which encodes the 3' half of the nCL-2' transcript.
CAPN11: A calpain with high mRNA levels in testis and located on chromosome 6.
Boehm et al., Freiburg, Germany. In Genomics, 1999
We report the identification of a new mammalian calpain gene, CAPN11.
Calcium dependent thiol protease caldonopain and its specific endogenous inhibitor in Leishmania donovani.
Datta et al., Calcutta, India. In Mol Cell Biochem, 1993
A calcium dependent proteolytic enzyme was detected in the lysed promastigotes of Leishmania donovani, the causative agent of kala-azar.
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