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Centrosomal protein 350kDa

The product of this gene is a large protein with a CAP-Gly domain typically found in cytoskeleton-associated proteins. The encoded protein primarily localizes to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. The encoded protein directly interacts with another large centrosomal protein and is required to anchor microtubules at the centrosome. It is also implicated in the regulation of a class of nuclear hormone receptors in the nucleus. Several alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: EB1, V1a, CAN, FGFR1, TRM1
Papers on CAP350
The OsSPL16-GW7 regulatory module determines grain shape and simultaneously improves rice yield and grain quality.
Fu et al., Beijing, China. In Nat Genet, Aug 2015
Here we show that a quantitative trait locus for rice grain quality, qGW7, reflects allelic variation of GW7, a gene encoding a TONNEAU1-recruiting motif protein with similarity to C-terminal motifs of the human centrosomal protein CAP350.
Alpha-catenin-dependent recruitment of the centrosomal protein CAP350 to adherens junctions allows epithelial cells to acquire a columnar shape.
Rios et al., Sevilla, Spain. In Plos Biol, Mar 2015
Here, we report that the centrosomal microtubule (MT)-binding protein CAP350 localises at adherens junctions in epithelial cells.
The deubiquitinating enzyme CYLD controls apical docking of basal bodies in ciliated epithelial cells.
Tassin et al., Orsay, France. In Nat Commun, 2013
Here we show that CYLD localizes at centrosomes and basal bodies via interaction with the centrosomal protein CAP350 and demonstrate that CYLD must be both at the centrosome and catalytically active to promote ciliogenesis independently of NF-κB.
The Arabidopsis TRM1-TON1 interaction reveals a recruitment network common to plant cortical microtubule arrays and eukaryotic centrosomes.
Pastuglia et al., Versailles, France. In Plant Cell, 2012
Interestingly, three motifs of TRMs are found in CAP350, a human centrosomal protein interacting with FOP, and the C-terminal M2 motif of CAP350 is responsible for FOP recruitment at the centrosome.
Role of CAP350 in centriolar tubule stability and centriole assembly.
Le Clech, Martinsried, Germany. In Plos One, 2007
By using RNA interference experiments, we show that the stability of growing procentrioles is regulated by the microtubule-stabilizing protein CAP350, independently of hSAS-6 and CPAP which initiate procentriole growth.
Myeloproliferative disorder FOP-FGFR1 fusion kinase recruits phosphoinositide-3 kinase and phospholipase Cgamma at the centrosome.
Birnbaum et al., Marseille, France. In Mol Cancer, 2007
RESULTS: We show that FOP-FGFR1 interacts with the large centrosomal protein CAP350 and that CAP350 is necessary for FOP-FGFR1 localisation at centrosome.
Centrosomal CAP350 protein stabilises microtubules associated with the Golgi complex.
Tassin et al., Paris, France. In J Cell Sci, 2007
CAP350 specifically stabilises Golgi-associated microtubules and in this way participates in the maintenance of a continuous pericentrosomal Golgi ribbon.
EB1 is required for primary cilia assembly in fibroblasts.
Pedersen et al., Copenhagen, Denmark. In Curr Biol, 2007
Finally, expression of a C-terminal fragment of the centrosomal protein CAP350, which removes EB1 from the centrosome but not MT plus ends [6], also inhibited ciliogenesis.
A complex of two centrosomal proteins, CAP350 and FOP, cooperates with EB1 in microtubule anchoring.
Nigg et al., Martinsried, Germany. In Mol Biol Cell, 2006
CAP350 interacts directly with FOP (FGFR1 oncogene partner) to form a centrosomal complex required for microtubule anchoring.
Activity and subcellular compartmentalization of peroxisome proliferator-activated receptor alpha are altered by the centrosome-associated protein CAP350.
Capone et al., Hamilton, Canada. In J Cell Sci, 2005
We show here that PPAR(alpha) interacts with the centrosome-associated protein CAP350.
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