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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Calcium modulating ligand

CAML, cyclophilin B-binding protein, CAMLG, Calcium modulating cyclophilin ligand
The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: TACI, CAN, V1a, BR-3, IgM
Papers on CAML
Emery-Dreifuss muscular dystrophy mutations impair TRC40-mediated targeting of emerin to the inner nuclear membrane.
Kehlenbach et al., Göttingen, Germany. In J Cell Sci, Jan 2016
Dominant negative fragments of the TRC40-receptor proteins WRB and CAML inhibited membrane insertion.
Calcium-Modulating Cyclophilin Ligand Is Essential for the Survival of Activated T Cells and for Adaptive Immunity.
Bram et al., Rochester, United States. In J Immunol, Jan 2016
Calcium-modulating cyclophilin ligand (CAML) is an endoplasmic reticulum resident protein that is widely expressed.
BAFF receptor and TACI in B-1b cell maintenance and antibacterial responses.
Alugupalli et al., Philadelphia, United States. In Ann N Y Acad Sci, Dec 2015
B cell-activating factor (BAFF) and a proliferation-inducing ligand (APRIL) mediate their function in mature B cells through the BAFF receptor (BAFFR) and transmembrane activator and CAML interactor (TACI).
TNF receptor superfamily member 13b (TNFRSF13B) hemizygosity reveals transmembrane activator and CAML interactor haploinsufficiency at later stages of B-cell development.
Meffre et al., New Haven, United States. In J Allergy Clin Immunol, Nov 2015
How mutant transmembrane activator and CAML interactor (TACI) influences wild-type TACI function is unclear; different models suggest either a dominant negative effect or haploinsufficiency.
CD19 controls Toll-like receptor 9 responses in human B cells.
Meffre et al., Konya, Turkey. In J Allergy Clin Immunol, Nov 2015
RESULTS: B cells from subjects with 1 or 2 defective CD19 alleles showed defective upregulation in vitro of CD86, transmembrane activator and CAML interactor (TACI), and CD23 activation markers after TLR9 stimulation.
Stoichiometry of Heteromeric BAFF and APRIL Cytokines Dictates Their Receptor Binding and Signaling Properties.
Schneider et al., Lausanne, Switzerland. In J Biol Chem, Jul 2015
Similar to APRIL, heteromers consisting of one BAFF and two APRILs (BAA) bind to the receptors B cell maturation antigen (BCMA), transmembrane activator and CAML interactor (TACI) but not to the BAFF receptor (BAFFR).
The emerging role of calcium-modulating cyclophilin ligand in posttranslational insertion of tail-anchored proteins into the endoplasmic reticulum membrane.
Sakisaka et al., Kōbe, Japan. In J Biochem, Jun 2015
We recently identified calcium-modulating cyclophilin ligand (CAML) as a TRC40 receptor, indicating that CAML was equivalent to Get2 in the context of the membrane insertion.
B-cell activating factor in the pathophysiology of multiple myeloma: a target for therapy?
Kersten et al., Amsterdam, Netherlands. In Blood Cancer J, 2014
Of these, only Transmembrane Activator and CAML Interactor (TACI) correlates with the MMC's capability to ligate BAFF.
The Get1/2 transmembrane complex is an endoplasmic-reticulum membrane protein insertase.
Denic et al., Cambridge, United States. In Nature, 2014
The Get3 endoplasmic-reticulum receptor comprises the cytosolic domains of the Get1/2 (WRB/CAML) transmembrane complex, which interact individually with the targeting factor to drive a conformational change that enables substrate release and, as a consequence, insertion.
Immune complex-mediated autoimmunity in a patient With Smith-Magenis syndrome (del 17p11.2).
Peterson et al., Minneapolis, United States. In J Clin Rheumatol, 2014
Molecular analysis using single-nucleotide polymorphism array confirmed a de novo 3.8-Mb deletion (breakpoints, chr17: 16,660,721-20,417,975), resulting in haploinsufficiency for TACI (transmembrane activator and CAML interactor).
Essential role for CAML in follicular B cell survival and homeostasis.
Bram et al., Rochester, United States. In J Immunol, 2012
Conditional deletion of CAML in CD19-Cre transgenic mice reduced follicular B cell numbers & increased rates of homeostatic proliferation. They had increased cellular turnover & normal proliferative ability.
Conditional deletion of calcium-modulating cyclophilin ligand causes deafness in mice.
Bram et al., Columbia, United States. In Mamm Genome, 2012
Deletion of calcium-modulating cyclophilin ligand causes deafness in mouse model.
Dengue virus utilizes calcium modulating cyclophilin-binding ligand to subvert apoptosis.
Huang et al., Nanning, China. In Biochem Biophys Res Commun, 2012
this study demonstrated that DENV manipulated the levels of CAML to subvert the apoptotic process which in turn favoured efficient virus production.
CAML promotes prolactin-dependent proliferation of breast cancer cells by facilitating prolactin receptor signaling pathways.
Park et al., Seoul, South Korea. In Breast Cancer Res Treat, 2011
CAML was found to play a crucial role in the PRL/PRLR-dependent growth of breast cancer cells.
Targeting B cells in immune-mediated inflammatory disease: a comprehensive review of mechanisms of action and identification of biomarkers.
Tak et al., Berlin, Germany. In Pharmacol Ther, 2010
More recently, there has been interest in markers such as B cell phenotype analysis, and B lymphocyte stimulator (BLyS)/a proliferation-inducing ligand (APRIL), the latter particularly in studies of the IgG Fc-transmembrane activator and CAML interactor (TACI) fusion protein (atacicept) and anti-BLyS therapy (belimumab).
Transmembrane and ubiquitin-like domain containing 1 (Tmub1) regulates locomotor activity and wakefulness in mice and interacts with CAMLG.
Ye et al., The Woodlands, United States. In Plos One, 2009
results implicate Tmub1 in the regulation of locomotor activity and wakefulness and suggest that Tmub1 binds to and functions together with CAMLG
Identification of calcium-modulating cyclophilin ligand as a human host restriction to HIV-1 release overcome by Vpu.
Spearman et al., Nashville, United States. In Nat Med, 2008
Here we identify calcium-modulating cyclophilin ligand (CAML) as a Vpu-interacting host factor that restricts HIV-1 release.
CAML is a p56Lck-interacting protein that is required for thymocyte development.
Bram et al., Rochester, United States. In Immunity, 2005
CAML as an essential mediator of T cell survival during thymopoiesis and its loss deregulates lymphocyte specific protein tyrosine kinase p56(p56Lck) signaling.
TACI-ligand interactions are required for T cell activation and collagen-induced arthritis in mice.
Grewal et al., San Francisco, United States. In Nat Immunol, 2001
Interactions of the tumor necrosis factor superfamily members B lymphocyte stimulator (BLyS) and a proliferation-inducing ligand (APRIL) with their receptors-transmembrane activator and CAML interactor (TACI) and B cell maturation molecule (BCMA)-on B cells play an important role in the humoral immune response.
APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity.
Theill et al., Thousand Oaks, United States. In Nat Immunol, 2000
APRIL functions via binding to BCMA (B cell maturation antigen) and TACI (transmembrane activator and CAML-interactor) and competes with TALL-I (also called BLyS or BAFF) for receptor binding.
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