gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Calcium/calmodulin-dependent protein kinase I

CaM kinase, CaMKI
Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CaM, ACID, CAN, V1a, HAD
Papers using CaM kinase antibodies
AMP-activated protein kinase: also regulated by ADP?
Zang Mengwei, In PLoS ONE, 2010
... Anti-CaMKKβ, anti-phospho-CaMKI (Thr 177) and CaMKI antibodies were purchased from Santa Cruz Biotechnology, Inc ...
Papers on CaM kinase
Single-Cell Memory Regulates a Neural Circuit for Sensory Behavior.
Mori et al., Nagoya, Japan. In Cell Rep, Feb 2016
Genetic and proteomic analyses found that the expression of the single-cell memory exhibits inter-individual variability, which is controlled by the evolutionarily conserved CaMKI/IV and Raf pathway.
Glutamate Release.
Ueda et al., Charlottesville, United States. In Neurochem Res, Dec 2015
Glutamate-loaded vesicles undergo removal of Synapsin I by CaM kinase II-mediated phosphorylation, transforming to the release-ready pool.
Regulation of Ca(2+)/calmodulin-dependent protein kinase phosphatase (CaMKP/PPM1F) by protocadherin-γC5 (Pcdh-γC5).
Sueyoshi et al., Japan. In Arch Biochem Biophys, Dec 2015
Dephosphorylation of phosphorylated Ca(2+)/calmodulin-dependent protein kinase I (CaMKI) by CaMKP was significantly activated by the C-terminal cytoplasmic fragment, Pcdh-γC5(715-944), both in vitro and in cells, suggesting that the C-terminal fragment functions as an endogenous activator of CaMKP.
C-terminal extension of calmodulin-like 3 protein from Oryza sativa L.: interaction with a high mobility group target protein.
Buaboocha et al., Bangkok, Thailand. In Acta Biochim Biophys Sin (shanghai), Nov 2015
Here, the CML3 protein from rice (OsCML3) and its truncated form lacking the C-terminal extension (OsCML3m) were found to exhibit a Ca(2+)-binding property and subsequent conformational change, but the ability to bind the CaM kinase II peptide was only observed for OsCML3m.
Evolutionary and functional perspectives on signaling from neuronal surface to nucleus.
Ma et al., New York City, United States. In Biochem Biophys Res Commun, May 2015
In C. elegans, the CaMK family is made up of only three members, and CREB phosphorylation is mediated by CMK-1, the homologue of CaMKI.
Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling.
Sengupta et al., Waltham, United States. In Elife, 2014
In this study, we show that CMK-1 CaMKI regulates the dauer decision as a function of feeding state.
Transcriptomic Analysis and Meta-Analysis of Human Granulosa and Cumulus Cells.
Lovrečić et al., Ljubljana, Slovenia. In Plos One, 2014
Among these there were genes that have previously not been reported in human somatic follicular cells, like prokineticin 2 (PROK2), higher expressed in GC, and pregnancy up-regulated nonubiquitous CaM kinase (PNCK), higher expressed in CC.
Gonadotrophin-releasing hormone signalling downstream of calmodulin.
Pnueli et al., Haifa, Israel. In J Neuroendocrinol, 2012
Gonadotrophin gene expression is also regulated by GnRH-induced CaM-dependent kinases (CaMKs); CaMKI is able to derepress the histone deacetylase-inhibition of β-subunit gene expression, whereas CaMKII appears to be essential for the GnRH-activation of all three subunit genes.
Calcium/calmodulin-dependent protein kinase kinase 2: roles in signaling and pathophysiology.
Means et al., Durham, United States. In J Biol Chem, 2012
CaMKK2 is one of the most versatile of the CaMKs and will phosphorylate and activate CaMKI, CaMKIV, and AMP-activated protein kinase.
Neurogenetics of slow axonal transport: from cells to animals.
Ray et al., Mumbai, India. In J Neurogenet, 2012
Recent reports have unraveled the molecular basis of the transport of certain slow component proteins, such as the neurofilament subunits, tubulin, and certain soluble enzymes such as Ca(2+)/calmodulin-dependent protein kinase IIa (CaM kinase IIa), etc., in tissue cultured neurons.
Genetic variants at CDC123/CAMK1D and SPRY2 are associated with susceptibility to type 2 diabetes in the Japanese population.
Maeda et al., Yokohama, Japan. In Diabetologia, 2011
A significant association of rs10906115 in CDC123/CAMK1D and rs1359790 near SPRY2 was identified with type 2 diabetes in a Japanese population.
Calcium/calmodulin-dependent protein kinase (CaMK) Ialpha mediates the macrophage inflammatory response to sepsis.
Rosengart et al., Pittsburgh, United States. In J Leukoc Biol, 2011
CaMKIalpha signaling is integral to the Mvarphi responding to LPS and may also be operant in vivo in regulating the inflammation and organ dysfunction consequent to sepsis.
Aldosterone producing adrenal adenomas are characterized by activation of calcium/calmodulin-dependent protein kinase (CaMK) dependent pathways.
Beuschlein et al., Freiburg, Germany. In Horm Metab Res, 2011
CaMKI was significantly upregulated in adrenal adenomas.
Acid activation of Trpv1 leads to an up-regulation of calcitonin gene-related peptide expression in dorsal root ganglion neurons via the CaMK-CREB cascade: a potential mechanism of inflammatory pain.
Yoneda et al., Suita, Japan. In Mol Biol Cell, 2010
Inflammatory acidic environments activate Trpv1, leading to an up-regulation of CGRP expression via CaMK-CREB cascade, a series of events that may be associated with inflammatory pain.
Human host factors required for influenza virus replication.
Chanda et al., In Nature, 2010
These include nuclear import components, proteases, and the calcium/calmodulin-dependent protein kinase (CaM kinase) IIbeta (CAMK2B).
Variants in doublecortin- and calmodulin kinase like 1, a gene up-regulated by BDNF, are associated with memory and general cognitive abilities.
Steen et al., Bergen, Norway. In Plos One, 2008
variants in doublecortin- and calmodulin kinase like 1, a gene up-regulated by BDNF, have roles in memory and general cognitive abilities
Ca(2+)/CaM-dependent kinases: from activation to function.
Means et al., Seattle, United States. In Annu Rev Pharmacol Toxicol, 2000
Among the many Ca(2+)/CaM-binding proteins to be discovered, the multifunctional protein kinases CaMKI, II, and IV play pivotal roles.
Lateral signaling mediated by axon contact and calcium entry regulates asymmetric odorant receptor expression in C. elegans.
Bargmann et al., San Francisco, United States. In Cell, 1999
This interaction induces str-2 expression by reducing calcium signaling through a voltage-dependent Ca2+ channel and the CaM kinase II UNC-43.
Diverse behavioural defects caused by mutations in Caenorhabditis elegans unc-43 CaM kinase II.
Thomas et al., Seattle, United States. In Nature, 1999
Calcium/calmodulin-dependent serine/threonine kinase type II (CaMKII) is one of the most abundant proteins in the mammalian brain, where it is thought to regulate synaptic plasticity and other processes.
CBP: a signal-regulated transcriptional coactivator controlled by nuclear calcium and CaM kinase IV.
Bading et al., Cambridge, United Kingdom. In Science, 1998
Recruitment of the coactivator, CREB binding protein (CBP), by signal-regulated transcription factors, such as CREB [adenosine 3', 5'-monophosphate (cAMP) response element binding protein], is critical for stimulation of gene expression.
share on facebooktweetadd +1mail to friends