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Calponin 3, acidic

calponin 3, CNN3
This gene encodes a protein with a markedly acidic C terminus; the basic N-terminus is highly homologous to the N-terminus of a related gene, CNN1. Members of the CNN gene family all contain similar tandemly repeated motifs. This encoded protein is associated with the cytoskeleton but is not involved in contraction. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: SM22alpha, Actin, OUT, fibrillin-1, CAN
Papers on calponin 3
Overexpressed Calponin3 by Subsonic Vibration Induces Neural Differentiation of hUC-MSCs by Regulating the Ionotropic Glutamate Receptor.
Kim et al., Seoul, South Korea. In Appl Biochem Biotechnol, Sep 2015
Among these proteins, calponin3 (CNN3) was confirmed to have 299 % higher expression in the 40-Hz SV stimulated hUC-MSCs group than that in the control by Western blotting.
Expression of AKR1C3 and CNN3 as markers for detection of lymph node metastases in colorectal cancer.
Kido et al., Kōbe, Japan. In Clin Exp Med, Aug 2015
The aim of the study was to identify a set of discriminating genes that could be used for the prediction of Lymph node (LN) metastasis in human colorectal cancer (CRC), and for this, we compared the whole genome profiles of two CRC cell lines (the primary cell line SW480 and its LN metastatic variant, SW620) and identified eight genes [S100 calcium-binding protein P; aldo-keto reductase family 1(AKR1), member B1 (aldose reductase; AKR1B1); AKR1, member C3 (AKR1C3); calponin 3, acidic; metastasis associated in colon cancer 1; hemoglobin, epsilon 1; trefoil factor 3; and FGGY carbohydrate kinase domain containing].
A Conditional Knockout Mouse Model Reveals That Calponin-3 Is Dispensable for Early B Cell Development.
Herzog et al., Freiburg, Germany. In Plos One, 2014
Whereas calponin-1 and calponin-2 have already been studied to some extent, little is known about the role of calponin-3 under physiological conditions due to the lack of an appropriate animal model.
CNN3 regulates trophoblast invasion and is upregulated by hypoxia in BeWo cells.
Dötsch et al., Köln, Germany. In Plos One, 2013
CNN3 is an ubiquitously expressed F-actin binding protein, shown to regulate trophoblast fusion and hence seems to play a role in the placentation process.
CNN3 is regulated by microRNA-1 during muscle development in pigs.
Li et al., Nanjing, China. In Int J Biol Sci, 2013
The calponin 3 (CNN3) gene has important functions involved in skeletal muscle development.
Calponin 3 regulates stress fiber formation in dermal fibroblasts during wound healing.
Wada et al., Izumi, Japan. In Arch Dermatol Res, 2013
In the present study, calponin 3 (CNN3), which has a phosphorylation-dependent actin-binding property, was identified in the molecular mechanism underlying stress fiber formation.
Rock-dependent calponin 3 phosphorylation regulates myoblast fusion.
Wada et al., Izumi, Japan. In Exp Cell Res, 2013
Herein, we show that acidic calponin or calponin 3 (CNN3) regulates both myoblast cell fusion and muscle-specific gene expressions.
Cyclic strain dominates over microtopography in regulating cytoskeletal and focal adhesion remodeling of human mesenchymal stem cells.
Russell et al., Chicago, United States. In Biochem Biophys Res Commun, 2013
Strain dominated over microtopography for expression of genes for the cytoskeleton (caldesmon-1 and calponin 3), cell adhesion (integrin-α2, vinculin, and paxillin), and extracellular matrix remodeling (MMP13) (p<0.05).
Comparative proteomic analysis of colon cancer cell HCT-15 in response to all-trans retinoic acid treatment.
Du et al., Hangzhou, China. In Protein Pept Lett, 2012
Among the identified differentially expressed proteins, there were four scaffold proteins (YWHAE, SFN, YWHAB, and YWHAZ), two ubiquitin modification related proteins (ISG-15 and UBE2N), two translational initiation factors (EIF1AX and EIF3K), two cytoskeleton related proteins (EZRI and CNN3), two proteinmodification related proteins (TXNDC17 and PIMT), and one enzyme related to phospholipid metabolism (PSP).
Increased expression of calponin-3 in epileptic patients and experimental rats.
Chen et al., Chongqing, China. In Exp Neurol, 2012
The mRNA and protein level of calponin-3 were increase expression in brain in patiens with epilepsy.
Sustained productivity in recombinant Chinese hamster ovary (CHO) cell lines: proteome analysis of the molecular basis for a process-related phenotype.
Clynes et al., Dublin, Ireland. In Bmc Biotechnol, 2010
Overlap comparisons between the two sets of cell line pairs identified 12 proteins (AKRIB8, ANXA1, ANXA4, EIF3I, G6PD, HSPA8, HSP90B1, HSPD1, NUDC, PGAM1, RUVBL1 and CNN3) that were differentially expressed in the same direction.
Calponin 3 regulates actin cytoskeleton rearrangement in trophoblastic cell fusion.
Wada et al., Izumi, Japan. In Mol Biol Cell, 2010
Results indicate that CNN3 regulates actin cytoskeleton rearrangement which is required for the plasma membranes of trophoblasts to become fusion competent.
h3/Acidic calponin: an actin-binding protein that controls extracellular signal-regulated kinase 1/2 activity in nonmuscle cells.
Morgan et al., Boston, United States. In Mol Biol Cell, 2010
h3/acidic calponin controls fibroblast migration by regulation of ERK1/2-mediated l-caldesmon phosphorylation.
Altered intra-nuclear organisation of heterochromatin and genes in ICF syndrome.
Volpi et al., Oxford, United Kingdom. In Plos One, 2009
In particular, we have compared in ICF (Type 1 and Type 2) and controls the large-scale organisation of chromosome 1 and 16 juxtacentromeric heterochromatic regions, their intra-nuclear positioning, and co-localisation with five specific genes (BTG2, CNN3, ID3, RGS1, F13A1), on which we have concurrently conducted expression and methylation analysis.
Transcriptional profiling of ErbB signalling in mammary luminal epithelial cells--interplay of ErbB and IGF1 signalling through IGFBP3 regulation.
Timms et al., London, United Kingdom. In Bmc Cancer, 2009
MYC, MAP2K1, MAP2K3), autocrine growth factor signalling (VEGF, PDGF) and adhesion/cytoskeletal regulation (ZYX, THBS1, VCL, CNN3, ITGA2, ITGA3, NEDD9, TAGLN), linking them to the hyper-poliferative and altered adhesive phenotype of the ErbB2-overexpressing cells.
Mucosa-associated lymphoid tissue lymphoma: novel translocations including rearrangements of ODZ2, JMJD2C, and CNN3.
Streubel et al., Vienna, Austria. In Clin Cancer Res, 2008
Gene rearrangements of CNN3 is associated with mucosa-associated lymphoid tissue lymphoma.
Identification of calponin 3 as a novel Smad-binding modulator of BMP signaling expressed in cartilage.
Aigner et al., Leipzig, Germany. In Exp Cell Res, 2007
These results suggest a role of calponin 3 in the regulation of Bone morphogenetic proteins -dependent cellular responses.
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