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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Calpain 9

calpain 9
member of the calpain large subunit family; predicted to have calpain cysteine protease activity [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Calpain, Inactive, calpastatin, iMpact, IDS
Papers on calpain 9
Effect of free thymol on differential gene expression in gastric mucosa of the young pig.
Trevisi et al., Reggio nell'Emilia, Italy. In Animal, 2014
Within this group, somatostatin (SST), SST receptors, peptide transporter 1 (SLC15A1) and calpain 9 (gastrointestinal tract-specific calpain) were the most strongly upregulated genes.
Calpain 8/nCL-2 and calpain 9/nCL-4 constitute an active protease complex, G-calpain, involved in gastric mucosal defense.
Sorimachi et al., Tokyo, Japan. In Plos Genet, 2010
Among the 15 mammalian calpains, calpain 8/nCL-2 and calpain 9/nCL-4 are predominantly expressed in the gastrointestinal tract and are restricted to the gastric surface mucus (pit) cells in the stomach.
Distinguishing between calpain heterodimerization and homodimerization.
Davies et al., Kingston, Canada. In Febs J, 2009
The PEF domain of digestive tract-specific calpain 9 heterodimerized with the small subunit, and that of calpain 13, prevalent in lung and testis, was mainly found as a homodimer with a small amount of heterodimer.
The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition.
Dhe-Paganon et al., Toronto, Canada. In J Mol Biol, 2007
Calpains have been implicated in multiple models of human disease; for instance, calpain 1 is activated in the brains of individuals with Alzheimer's disease, and the digestive tract specific calpain 9 is down-regulated in gastric cancer cell lines.
Identification of a novel gill-specific calpain from rainbow trout (Oncorhynchus mykiss).
Yao et al., Morgantown, United States. In Fish Physiol Biochem, 2006
Comparison of the novel protein with the ubiquitously expressed calpains and several mammalian tissue-specific calpains revealed that the novel calpain is an orthologue of the mammalian digestive tract specific calpain (calpain 9).
Down-regulation of calpain 9 is linked to hypertensive heart and kidney disease.
Wohlfart et al., Frankfurt am Main, Germany. In Cell Physiol Biochem, 2004
differential regulation of calpain 9 may play a role in hypertensive target organ damage
The calpain family and human disease.
Wang et al., Ann Arbor, United States. In Trends Mol Med, 2001
Calpain 10 was recently identified as a susceptibility gene for type 2 diabetes, whereas calpain 9 appears to be a gastric cancer suppressor.
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