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Calcyon neuron-specific vesicular protein

Calcyon, Caly
dopamine receptor 1 (D1R) of D1-like receptors interacting protein [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: ACID, CAN, OUT, HAD, AGE
Papers on Calcyon
Calcyon stimulates neuregulin 1 maturation and signaling.
Bergson et al., Shanghai, China. In Mol Psychiatry, Oct 2015
Here we show that the neuronal vesicular protein calcyon is a potent activator and key determinant of NRG1 ED cleavage and shedding.
Complementary roles of the neuron-enriched endosomal proteins NEEP21 and calcyon in neuronal vesicle trafficking.
Bergson et al., Raleigh, United States. In J Neurochem, 2015
Investigation of the neuron-enriched endosomal protein of 21 kDa (NEEP21, or NSG1or P21) and Calcyon (Caly, or NSG3) indicates that the emergence of the NEEP21/Caly/P19 gene family could play a vital role in the success of these mechanisms in vertebrates.
Calyculin A from Discodermia calyx is a dual action toxin that blocks calcium influx and inhibits protein Ser/Thr phosphatases.
Brautigan et al., Charlottesville, United States. In Toxins (basel), 2012
Calyculin A (Caly A) is cell permeable toxin widely used in cell biology research as an inhibitor of type 1 and type 2A protein Ser/Thr phosphatases of the PPP family.
Calcyon, a mammalian specific NEEP21 family member, interacts with adaptor protein complex 3 (AP-3) and regulates targeting of AP-3 cargoes.
Bergson et al., Augusta, United States. In J Neurochem, 2012
The data of this study suggested that calcyon directly interacts with mu3A and mu3B, and regulates the subcellular distribution of AP-3 and the targeting of AP-3 cargoes.
Calcyon forms a novel ternary complex with dopamine D1 receptor through PSD-95 protein and plays a role in dopamine receptor internalization.
Chang et al., Seoul, South Korea. In J Biol Chem, 2012
Calcyon, once known for interacting directly with the dopamine D(1) receptor (D(1)DR), is implicated in various neuropsychiatric disorders including schizophrenia, bipolar disorder, and attention deficit hyperactivity disorder.
Intrinsic migratory properties of cultured Schwann cells based on single-cell migration assay.
Huang et al., Wenzhou, China. In Plos One, 2011
Decreasing this front-to-rear difference of myosin II activity by frontal application of a ML-7 or BDM (myosin II inhibitors) gradient induced the collapse of leading front and reversed soma translocation, whereas, increasing this front-to-rear difference of myosin II activity by rear application of a ML-7 or BDM gradient or frontal application of a Caly (myosin II activator) gradient accelerated soma translocation.
Calcyon upregulation in adolescence impairs response inhibition and working memory in adulthood.
Bergson et al., Augusta, United States. In Mol Psychiatry, 2011
The resultd of this study showed that with calcyon-overexpressing Cal(OE) transgenic mice that lifelong calcyon upregulation impairs executive functions including response inhibition and working memory.
Phylogenetic analysis of the NEEP21/calcyon/P19 family of endocytic proteins: evidence for functional evolution in the vertebrate CNS.
Bergson et al., Augusta, United States. In J Mol Evol, 2009
Here, we report the first phylogenetic study of NEEP21, calcyon, and P19, a family of neuronal proteins implicated in synaptic receptor endocytosis and recycling, as well as in membrane protein trafficking in the somatodendritic and axonal compartments of differentiated neurons.
Calcyon is necessary for activity-dependent AMPA receptor internalization and LTD in CA1 neurons of hippocampus.
Bergson et al., Augusta, United States. In Eur J Neurosci, 2009
Taken together, the present studies involving biochemical, immunological and electrophysiological analyses raise the possibility that calcyon plays a specialized role in regulating activity-dependent removal of synaptic AMPARs.
A comparison of molecular alterations in environmental and genetic rat models of ADHD: a pilot study.
Faraone et al., Syracuse, United States. In Am J Med Genet B Neuropsychiatr Genet, 2009
Genes with altered expression only in the SHRs included Oprm1, Calcyon, Calmodulin, Lhx1, and Hes6.
Up-regulation of calcyon results in locomotor hyperactivity and reduced anxiety in mice.
Bergson et al., Charleston, United States. In Behav Brain Res, 2008
Transgenic mice display a range of abnormal behaviors including spontaneous hyperactivity, reduced anxiety, and/or impaired restraint (harm avoidance) that would indicate that calcyon up-regulation leads to deficits in control over behavioral output.
Pathology of spontaneous dermatitis in CBy.ALY-aly mice.
Nawa et al., Kyoto, Japan. In Exp Anim, 2008
CBy.ALY-aly/aly (C-aly) mice develop progressive dermatitis in areas of the face and dorsal neck from around three months of age.
Intracellular dynamics of calcyon, a neuron-specific vesicular protein.
Scott et al., Stockholm, Sweden. In Neuroreport, 2007
Calcyon is a brain-specific protein, implicated in clathrin-mediated endocytosis.
Calcyon mRNA expression in the frontal-striatal circuitry and its relationship to vesicular processes and ADHD.
Castellanos et al., Stockholm, Sweden. In Behav Brain Funct, 2006
BACKGROUND: Calcyon is a single transmembrane protein predominantly expressed in the brain.
Calcyon, a novel partner of clathrin light chain, stimulates clathrin-mediated endocytosis.
Bergson et al., Augusta, United States. In J Biol Chem, 2006
Using the calcyon cytosolic domain as bait, we isolated clathrin light chain in a yeast two-hybrid screen.
Dual signaling regulated by calcyon, a D1 dopamine receptor interacting protein.
Bergson et al., Augusta, United States. In Science, 2000
Here a 24-kilodalton single transmembrane protein, designated calcyon, we functionally characterize that interacts with the D1 dopamine receptor.
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