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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Calcitonin receptor

calcitonin receptor
receptor for calcitonin; acts via adenylate cyclase signaling [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Calcitonin, adrenomedullin, ACID, RAMP1, calcitonin receptor-like receptor
Papers on calcitonin receptor
Amylin receptor components and the leptin receptor are co-expressed in single rat area postrema neurons.
Lutz et al., Zürich, Switzerland. In Eur J Neurosci, Feb 2016
AMY are heterodimers that include a calcitonin receptor (CTR) subunit (CTRa or CTRb) and a member of the receptor activity modifying proteins (RAMPs).
Gene array of PDL cells exposed to Osteogain in combination with a bone grafting material.
Zhang et al., Québec, Canada. In Clin Oral Investig, Feb 2016
Interestingly, Osteogain promoted calcitonin receptor 55-fold and also promoted annexin A5 gene expression over 12-fold.
Functional Analysis of the Adrenomedullin Pathway in Malignant Pleural Mesothelioma.
Ouafik et al., Marseille, France. In J Thorac Oncol, Jan 2016
Adrenomedullin (AM) is a multifunctional peptide that is highly expressed in several tumors and plays an important role in angiogenesis and tumor growth after binding to its receptors, calcitonin receptor-like receptor/receptor activity-modifying protein 2 (CLR/RAMP2) and calcitonin receptor-like receptor/receptor activity-modifying protein 3 (CLR/RAMP3).
Dihydroartemisinin, an Anti-Malaria Drug, Suppresses Estrogen Deficiency-Induced Osteoporosis, Osteoclast Formation and RANKL Induced Signalling Pathways.
Xu et al., Perth, Australia. In J Bone Miner Res, Jan 2016
Dihydroartemisin inhibited the expression of osteoclast marker genes such as cathepsin K, calcitonin receptor, and TRAcP.
Endogenous VMH amylin signaling is required for full leptin signaling and protection from diet-induced obesity.
Levin et al., Zürich, Switzerland. In Am J Physiol Regul Integr Comp Physiol, Jan 2016
Since DIO (125)I-amylin dorsomedial nucleus (DMN)-dorsomedial VMN (VMNdm) binding was reduced, we postulated that this contributed to DIO VMH leptin resistance and that impairing ventromedial hypothalamic (VMH: ARC + VMN) CTR-mediated signaling by injecting adeno-associated virus (AAV) expressing a short hairpin calcitonin receptor (CTR) would predispose diet-resistant (DR) rats to obesity on high fat (45%) diet (HFD).
Fluorescently labeled adrenomedullin allows real-time monitoring of adrenomedullin receptor trafficking in living cells.
Beck-Sickinger et al., Leipzig, Germany. In J Pept Sci, Dec 2015
For potential use in clinical applications, we aimed to investigate the fate of the peptide ligand after binding and activation of the adrenomedullin receptor (AM1 ), a heterodimer consisting of the calcitonin receptor-like receptor (CLR), a G protein-coupled receptor, associated with the receptor activity-modifying protein 2 (RAMP2).
Bench-to-bedside pharmacology of adrenomedullin.
Kitamura et al., Miyazaki, Japan. In Eur J Pharmacol, Nov 2015
These activities are assumed to be mediated via the specific receptor formed by calcitonin receptor-like receptor and receptor activity-modifying protein 2 or 3, while some questions remain to be answered about the molecular mechanisms of this signal transduction system.
IAPP-driven metabolic reprogramming induces regression of p53-deficient tumours in vivo.
Flores et al., Houston, United States. In Nature, Mar 2015
We found that IAPP is causally involved in this tumour regression and that amylin functions through the calcitonin receptor (CalcR) and receptor activity modifying protein 3 (RAMP3) to inhibit glycolysis and induce reactive oxygen species and apoptosis.
Calcitonin gene-related peptide: physiology and pathophysiology.
Brain et al., London, United Kingdom. In Physiol Rev, 2014
These receptors consist of calcitonin receptor-like receptor (CLR) linked to an essential receptor activity modifying protein (RAMP) that is necessary for full functionality.
Intermedin/adrenomedullin2: an autocrine/paracrine factor in vascular homeostasis and disease.
Qi et al., Beijing, China. In Sci China Life Sci, 2014
Via calcitonin receptor-like receptor/receptor activity modifying proteins, the common receptor complexes of CGRP, IMD exerts a wide range of biological effects, especially regulation of cardiovascular homeostasis.
Crucial protein based drug targets and potential inhibitors for osteoporosis: new hope and possibilities.
Doss et al., India. In Curr Drug Targets, 2013
We have highlighted the existing potential protein drug targets, oestrogen receptor, calcium sensing receptor, P2Y receptor, activin receptor, calcitonin receptor, therapeutic manipulation of protease class such as cathepsin K, targeting WNT/ β-catenin signaling and targeting RANK-RANKL signaling pathway, TNF inhibition through TNF receptor.
Roles of CLR/RAMP receptor signaling in reproduction and development.
Hsu et al., Taiwan. In Curr Protein Pept Sci, 2013
Recent research into their functions in reproduction has illuminated the role of these peptides and their cognate receptors (calcitonin receptor-like receptor/receptor activity-modifying protein (CLR/RAMP) receptors) in fetal-maternal blood circulation, fetoplacental development, female gamete development, and gamete movement in the oviduct.
The calcitonin receptor gene is a candidate for regulation of susceptibility to herpes simplex type 1 neuronal infection leading to encephalitis in rat.
Diez et al., Stockholm, Sweden. In Plos Pathog, 2011
variability in Calcr was identified as potentially critical for infection and viral spread to the CNS and subsequent Herpes simplex encephalitis development.
Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay.
Akira et al., Suita, Japan. In Nature, 2009
Overexpression of Zc3h12a accelerated Il6 mRNA degradation via its 3'-untranslated region (UTR), and destabilized RNAs with 3'-UTRs for genes including Il6, Il12p40 and the calcitonin receptor gene Calcr.
Receptor activity-modifying proteins differentially modulate the G protein-coupling efficiency of amylin receptors.
Sexton et al., Australia. In Endocrinology, 2008
RAMP interaction with the CTRa in COS-7 or HEK-293 cells leads to selective modulation of signaling pathways activated by the receptor complex.
International Union of Pharmacology. LXIX. Status of the calcitonin gene-related peptide subtype 2 receptor.
International Union of Pharmacology et al., Birmingham, United Kingdom. In Pharmacol Rev, 2008
After the cloning of calcitonin receptor-like receptor (CLR) and receptor activity-modifying proteins (RAMPs), it became clear that the CGRP(1) receptor was a complex between CLR and RAMP1.
Immunohistochemical mapping of calcitonin receptors in the adult rat brain.
Lutz et al., Zürich, Switzerland. In Brain Res, 2005
Abundant expression of calcitonin C1 receptors was found in the nucleus accumbens, lateral arcuate nucleus, lateral substantia nigra, bed nucleus, locus coeruleus, area postrema, nucleus of the solitary tract, and some nuclei of the reticular formation.
Vascular actions of calcitonin gene-related peptide and adrenomedullin.
Grant et al., London, United Kingdom. In Physiol Rev, 2004
All three peptides can act on a family of CGRP receptors that consist of calcitonin receptor-like receptor (CL) linked to one of three receptor activity-modifying proteins (RAMPs) that are essential for functional activity.
Peripheral amylin activates circumventricular organs expressing calcitonin receptor a/b subtypes and receptor-activity modifying proteins in the rat.
Rechkemmer et al., Karlsruhe, Germany. In Brain Res, 2004
By using in situ hybridization, the codistribution of CT((a))/CT((b)) with RAMP1-3 and c-fos was mapped in CVOs of rats.
Calcitonin receptor isoforms expressed in the developing rat kidney.
Wookey et al., Melbourne, Australia. In Kidney Int, 2003
calcitonin receptor C1a protein expression has been identified in the ureteric ducts in the metanephros and both isoforms expressed in the distal portions of the developing nephrons and collecting ducts
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