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Filamin binding LIM protein 1

Cal, S100A11
This gene encodes a protein with an N-terminal filamin-binding domain, a central proline-rich domain, and, multiple C-terminal LIM domains. This protein localizes at cell junctions and may link cell adhesion structures to the actin cytoskeleton. This protein may be involved in the assembly and stabilization of actin-filaments and likely plays a role in modulating cell adhesion, cell morphology and cell motility. This protein also localizes to the nucleus and may affect cardiomyocyte differentiation after binding with the CSX/NKX2-5 transcription factor. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, S-100, HAD, ACID, V1a
Papers using Cal antibodies
Elevation of human α-defensins and S100 calcium binding protein A8 and A9 in tear fluid of pterygium patients.
Tong Louis et al., In Molecular Vision, 2008
... Mouse monoclonal antibodies against S100A4, S100A6, S100A9, and S100A11 were purchased from Abnova (Taipei, Taiwan), and mouse ...
A novel LIM protein Cal promotes cardiac differentiation by association with CSX/NKX2-5
Komuro Issei et al., In The Journal of Cell Biology, 1998
... Molecular cloning of CalWe performed a yeast two-hybrid screening using the MATCHMAKER Two-Hybrid System (CLONTECH Laboratories, Inc.) as described ...
Protein measurement with the Folin phenol reagent.
Hartl Dominik, In PLoS ONE, 1950
... Monoclonal anti-Cal-1 (9A4H8D3, ab3589) and polyclonal anti-Cal-2 (2539) were purchased from abcam and Cell Signaling, respectively ...
Papers on Cal
A systematic review of biomarkers in the diagnosis of infective endocarditis.
Honoré et al., Århus, Denmark. In Int J Cardiol, Feb 2016
Based on current research, N-terminal-pro-B-type natriuretic peptide (NT-proBNP) alone or in combination with Cystatin C (Cys C), lipopolysaccharide-binding protein (LBP), troponins, aquaporin-9 (AQP9), S100 calcium binding protein A11 (S100A11), E-selectin (CD62E) and VCAM-1 (CD54) and interleukin-6 (IL-6) are potential biomarkers for future studies.
A mitochondrial redox oxygen sensor in the pulmonary vasculature and ductus arteriosus.
Archer et al., Kingston, Canada. In Pflugers Arch, Jan 2016
In PASMCs, hypoxia inhibits ROS production and reduces redox couples, thereby inhibiting O2-sensitive voltage-gated potassium (Kv) channels, depolarizing the plasma membrane, activating voltage-gated calcium channels (CaL), increasing [Ca(2+)]i, and causing vasoconstriction.
ROS-activated ATM-dependent phosphorylation of cytoplasmic substrates identified by large scale phosphoproteomics screen.
Lavin et al., Australia. In Mol Cell Proteomics, Jan 2016
We validated the phosphorylation of three of these proteins (OSR1, HDGF and ccdc82) as ATM-dependent after H2O2 exposure and another protein (S100A11) demonstrated ATM-dependence for translocation from the cytoplasm to the nucleus.
Suppression of A549 cell proliferation and metastasis by calycosin via inhibition of the PKC‑α/ERK1/2 pathway: An in vitro investigation.
Jia et al., Suzhou, China. In Mol Med Report, Dec 2015
Calycosin (Cal), an effector chemical from Astragalus has been reported to affect the recurrence and metastasis of cancer cells via the regulation of the protein expression of matrix metalloproteinases (MMPs).
A comparison of fluorescent Ca(2+) indicators for imaging local Ca(2+) signals in cultured cells.
Smith et al., Irvine, United States. In Cell Calcium, Dec 2015
Altogether, nine synthetic Ca(2+) dyes (Fluo-4, Fluo-8, Fluo-8 high affinity, Fluo-8 low affinity, Oregon Green BAPTA-1, Cal-520, Rhod-4, Asante Calcium Red, and X-Rhod-1) and three genetically-encoded Ca(2+)-indicators (GCaMP6-slow, -medium and -fast variants) were tested; criteria include the magnitude, kinetics, signal-to-noise ratio and detection efficiency of local Ca(2+) puffs.
Expression of S100A11 is a Prognostic Factor for Disease-free Survival and Overall Survival in Patients With High-grade Serous Ovarian Cancer.
Zhang et al., Shanghai, China. In Appl Immunohistochem Mol Morphol, Dec 2015
UNASSIGNED: S100A11 is a calcium-binding protein implicated in a variety of biological functions and is overexpressed in many human cancers.
Inhibition of cell adhesion by phosphorylated Ezrin/Radixin/Moesin.
Miyake et al., Tsukuba, Japan. In Cell Adh Migr, Dec 2015
Treatment with Calyculin-A (Cal-A), a protein phosphatase inhibitor, dramatically augmented phosphorylated ERM (phospho-ERM).
Evaluation and screening of mRNA S100A genes as serological biomarkers in different stages of bladder cancer in Egypt.
Abozeed et al., Cairo, Egypt. In Tumour Biol, Nov 2015
Both S100A8 and S100A9 can be used for detection of invasive bladder carcinoma while S100A11 can be used for early detection of superficial bladder carcinoma.
S100A11 is a potential prognostic marker for clear cell renal cell carcinoma.
Yousef et al., London, Canada. In Clin Exp Metastasis, Nov 2015
We investigated the expression of the S100A11 protein in 385 patients with primary ccRCC using immunohistochemistry on tissue microarrays.
Annexins are instrumental for efficient plasma membrane repair in cancer cells.
Nylandsted et al., Copenhagen, Denmark. In Semin Cell Dev Biol, Sep 2015
Plasma membrane repair in cancer cells depends on ANXA2 protein, which is recruited to the wound site and forms a complex with the Ca(2+)-binding EF-hand protein S100A11.
Diacerein retards cell growth of chondrosarcoma cells at the G2/M cell cycle checkpoint via cyclin B1/CDK1 and CDK2 downregulation.
Steinecker-Frohnwieser et al., Graz, Austria. In Bmc Cancer, 2014
Furthermore, diacerein treatment increased the phosphorylation of p38α and p38β MAPKs, and Akt1, Akt2, and Akt 3 in SW-1353, whereas in Cal-78 the opposite effect has been demonstrated.
Up-Regulation of S100A11 in Lung Adenocarcinoma - Its Potential Relationship with Cancer Progression.
Masuda et al., Yokohama, Japan. In Plos One, 2014
The aim of the present study was to elucidate the potential molecular basis of these highly malignant lung tumors by focusing on S100 proteins (S100A2, S100A7, and S100A11), which are downstream targets of oncogenic KRAS and promoters of tumor progression.
Joining S100 proteins and migration: for better or for worse, in sickness and in health.
Rudland et al., Birmingham, United Kingdom. In Cell Mol Life Sci, 2014
This review summarises some of the reported regulatory functions of S100 proteins (namely S100A1, S100A2, S100A4, S100A6, S100A7, S100A8/S100A9, S100A10, S100A11, S100A12, S100B and S100P) on cellular migration and invasion, established in both culture and animal model systems and the possible mechanisms that have been proposed to be responsible.
S100 family signaling network and related proteins in pancreatic cancer (Review).
Xiao et al., Nantong, China. In Int J Mol Med, 2014
S100A11 and S100P are significant tumor markers for pancreatic cancer and unfavorable predictors for the prognosis of patients who have undergone surgical resection.
Critical role of filamin-binding LIM protein 1 (FBLP-1)/migfilin in regulation of bone remodeling.
Wu et al., Pittsburgh, United States. In J Biol Chem, 2012
results identify FBLP-1 as a key regulator of bone homeostasis and suggest that FBLP-1 functions in this process through modulating both the intrinsic properties of OB/BMSCs (i.e., BMSC-extracellular matrix adhesion and migration
Filamin a regulates neural progenitor proliferation and cortical size through Wee1-dependent Cdk1 phosphorylation.
Sheen et al., Boston, United States. In J Neurosci, 2012
This study demonistrated that a molecular mechanism whereby FlnA loss impaired G2 to M phase entry, leading to cell cycle prolongation, compromised neural progenitor proliferation, and reduced brain size.
Involvement of S100A14 protein in cell invasion by affecting expression and function of matrix metalloproteinase (MMP)-2 via p53-dependent transcriptional regulation.
Liu et al., Beijing, China. In J Biol Chem, 2012
that S100A14 promotes cell motility and invasiveness by regulating the expression and function of MMP2 in a p53-dependent manner.
Migfilin regulates esophageal cancer cell motility through promoting GSK-3β-mediated degradation of β-catenin.
Liu et al., Beijing, China. In Mol Cancer Res, 2012
Migfilin promoted beta-catenin degradation by reinforcing the association between beta-catenin and GSK-3beta.
The gene expression analysis of blood reveals S100A11 and AQP9 as potential biomarkers of infective endocarditis.
Mege et al., Marseille, France. In Plos One, 2011
Using transcriptional signatures of blood samples,identified S100A11 as a potential diagnostic marker of infective endocarditis, and AQP9 as a potential prognostic factor.
Synaptic excitation may activate a calcium-dependent potassium conductance in hippocampal pyramidal cells.
Alger et al., In Science, 1981
In hippocampal CAl pyramidal cells, orthodromic synaptic excitation is followed by an early hyperpolarization mediated by gamma-aminobutyric acid (GABA) and a late non-GABA-mediated hyperpolarization that has properties consistent with an increase in potassium conductance.
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