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Cadherin 8

cadherin-8, Cad8, CDH8
This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and guidance. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: cadherin-6, cadherin-11, R-cadherin, cadherin-7, N-cadherin
Papers on cadherin-8
Complex and dynamic expression of cadherins in the embryonic marmoset cerebral cortex.
Iriki et al., Wako, Japan. In Dev Growth Differ, Aug 2015
Previously, we analyzed the expression of nine classic cadherins (Cdh4, Cdh6, Cdh7, Cdh8, Cdh9, Cdh10, Cdh11, Cdh12, and Cdh20) and T-cadherin (Cdh13) in the developing postnatal common marmoset (Callithrix jacchus) brain, and found differential expressions between mice and marmosets.
T-Brain-1--A Potential Master Regulator in Autism Spectrum Disorders.
Hsueh et al., Taipei, Taiwan. In Autism Res, Aug 2015
A further five of the 24 genes (Cd44, Cdh8, Cntn6, Gpc6, and Ntng1) encode membrane proteins that regulate cell adhesion and axonal outgrowth.
Cadherin-8 expression, synaptic localization, and molecular control of neuronal form in prefrontal corticostriatal circuits.
Benson et al., New York City, United States. In J Comp Neurol, 2015
Here, we used regional and cellular in situ hybridization techniques coupled with neuronal tract tracing to show that Cadherin-8 (Cdh8), a homophilic adhesion protein encoded by a gene associated with autism spectrum disorders and learning disability susceptibility, is enriched within striatal projection neurons in the medial prefrontal cortex and in striatal medium spiny neurons forming the direct or indirect pathways.
Brain-specific transcriptional regulator T-brain-1 controls brain wiring and neuronal activity in autism spectrum disorders.
Hsueh et al., Taipei, Taiwan. In Front Neurosci, 2014
In addition to Grin2b, cell adhesion molecules-including Ntng1, Cdh8, and Cntn2-are also regulated by TBR1 to control axonal projections of amygdala.
Complementary and dynamic type II cadherin expression associated with development of the primate visual system.
Iriki et al., Wako, Japan. In Dev Growth Differ, 2014
In the prenatal brain, cadherin-6 was dominantly expressed in the pulvino-MT pathway whereas cadherin-8 was dominant in the lateral geniculate nucleus (LGN)-V1 pathway.
Inversion of layer-specific cadherin expression profiles and maintenance of cytoarchitectonic areas in the allocortex of the reeler mutant mouse.
Schmid-Hertel et al., Jena, Germany. In J Comp Neurol, 2014
To investigate in detail how layer formation and regionalization is perturbed in the phylogenetically older archicortex of the adult reeler mutant mouse, we studied the expression of 11 different cadherins (Cdh4, Cdh7, Cdh8, Cdh11, Pcdh1, Pcdh7, Pcdh8, Pcdh9, Pcdh10, Pcdh17, and Pcdh19) and of the transcription factors ER81 and Cux2 by in situ hybridization in the (peri-)archicortex.
Developmental localization of adhesion and scaffolding proteins at the cone synapse.
Fuerst et al., Moscow, United States. In Gene Expr Patterns, 2014
In this study we characterize the localization of adhesion and scaffolding proteins that are localized to the cone synapse, including alpha-n-catenin, beta-catenin, gamma-protocadherin, cadherin-8, MAGI2 and CASK.
Tbr1 haploinsufficiency impairs amygdalar axonal projections and results in cognitive abnormality.
Hsueh et al., Taipei, Taiwan. In Nat Neurosci, 2014
Loss of a copy of the Tbr1 gene altered the expression of Ntng1, Cntn2 and Cdh8 and reduced both inter- and intra-amygdalar connections.
Restricted expression of classic cadherins in the spinal cord of the chicken embryo.
Redies et al., Jena, Germany. In Front Neuroanat, 2013
In the present study, we compared the expression patterns of 10 classic cadherins (Cdh2, Cdh4, Cdh6, Cdh7, Cdh8, Cdh9, Cdh11, Cdh12, Cdh18, and Cdh20) in the developing chicken spinal cord (SP) by in situ hybridization.
An eQTL mapping approach reveals that rare variants in the SEMA5A regulatory network impact autism risk.
Weiss et al., San Francisco, United States. In Hum Mol Genet, 2013
The SEMA5A regulatory network includes previous autism candidate genes and regions, including MACROD2, A2BP1, MCPH1, MAST4, CDH8, CADM1, FOXP1, AUTS2, MBD5, 7q21, 20p, USH2A, KIRREL3, DBF4B and RELN, among others.
Morphology of the facial motor nuclei in a rat model of autism during early development.
Narita et al., Japan. In Int J Dev Neurosci, 2013
Signals for cadherin 8, which is expressed in mature facial nuclei, revealed that exposure to VPA caused a significant reduction in the size of the facial nuclei.
Pemphigus vulgaris autoantibody profiling by proteomic technique.
Grando et al., Irvine, United States. In Plos One, 2012
The frequency of antigen recognition by patients that exceeded that of control by 10 and more times were the molecules encoded by the CD33, GP1BA, CHRND, SLC36A4, CD1B, CD32, CDH8, CDH9, PMP22 and HLA-E genes as well as mitochondrial proteins encoded by the NDUFS1, CYB5B, SOD2, PDHA1 and FH genes.
Identification of candidate intergenic risk loci in autism spectrum disorder.
Scherer et al., Toronto, Canada. In Bmc Genomics, 2012
Examples of such intergenic CNV regions include 16q21 and 2p16.3 near known ASD risk genes CDH8 and NRXN1 respectively, as well as novel loci contiguous with ZHX2, MOCS1, LRRC4C, SEMA3C, and other genes.
Cadherins and neuropsychiatric disorders.
Hübner et al., Jena, Germany. In Brain Res, 2012
For example, CDH15 and PCDH19 are associated with cognitive impairment; CDH5, CDH8, CDH9, CDH10, CDH13, CDH15, PCDH10, PCDH19 and PCDHb4 with autism; CDH7, CDH12, CDH18, PCDH12 and FAT with bipolar disease and schizophrenia; and CDH11, CDH12 and CDH13 with methamphetamine and alcohol dependency.
Synaptic loss and retention of different classic cadherins with LTP-associated synaptic structural remodeling in vivo.
Steward et al., New York City, United States. In Hippocampus, 2012
Loss of cadherin-8 probably represents selective removal from synapses rather than overall loss of synaptic junctions.
Ectopic expression of cadherin 8 is sufficient to cause cyst formation in a novel 3D collagen matrix renal tubule culture.
Bacallao et al., Indianapolis, United States. In Am J Physiol Cell Physiol, 2011
cadherin 8, a type II neuronal cadherin, is expressed in cyst epithelia both in vivo and in vitro; data suggest that ectopic expression of cadherin 8 in renal epithelial cells is sufficient to cause the morphogenic pattern of cyst formation
Rare familial 16q21 microdeletions under a linkage peak implicate cadherin 8 (CDH8) in susceptibility to autism and learning disability.
Monaco et al., Oxford, United Kingdom. In J Med Genet, 2011
Rare familial 16q21 microdeletions and expression analysis implicate CDH8 in susceptibility to autism and learning disabilities.
Dynamic properties of a type II cadherin adhesive domain: implications for the mechanism of strand-swapping of classical cadherins.
Palmer et al., New York City, United States. In Structure, 2008
Results describe individual monomer and dimer states and the monomer-dimer equilibrium of the mouse Type II cadherin-8 EC1 domain.
Cadherin-8 and N-cadherin differentially regulate pre- and postsynaptic development of the hippocampal mossy fiber pathway.
Benson et al., New York City, United States. In Hippocampus, 2007
Cadherin-8 and N-cadherin are critical for generating the mossy fiber pathway, but each contributes uniquely to afferent and target differentiation, thereby complementing one another in the assembly of a synaptic circuit.
Patch/matrix patterns of gray matter differentiation in the telencephalon of chicken and mouse.
Puelles et al., Essen, Germany. In Brain Res Bull, 2002
For example, members of the cadherin family of adhesion molecules (cadherin-8 and OL-protocadherin) are differentially expressed by the striosomes and the striatal matrix.
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