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Calcium channel, voltage-dependent, gamma subunit 4
CACNG4, voltage-dependent calcium channel gamma4 subunit
The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type II TARP and a calcium channel gamma subunit. [provided by RefSeq, Dec 2010] (from
NCBI)
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Top mentioned proteins:
WAG, CAN, CACNG5, CACNLG, SNAP-25
Papers on
CACNG4
Transforming growth factor-β1 primes proliferating adult neural progenitor cells to electrophysiological functionality.
Regensburg, Germany. In Glia, 2013
Gene chip array analyses revealed upregulation of voltage-dependent ion channel subunits (Kcnd3, Scn1b, Cacng4, and Accn1), neurotransmitters, and synaptic proteins (Cadps, Snap25, Grik4, Gria3, Syngr3, and Gria4) as well as other neuronal proteins (doublecortin [DCX], Nrxn1, Sept8, and Als2cr3).
Candidate genes for sensitivity and resistance of human glioblastoma multiforme cell lines to erlotinib. Laboratory investigation.
Heidelberg, Germany. In J Neurosurg, 2009
Functional annotation analysis revealed that 2 genes (DUSP4 and STAT1) were significantly associated with sensitivity to erlotinib, and 10 genes (CACNG4, FGFR4, HSPA1B, HSPB1, NFATC1, NTRK1, RAC1, SMO, TCF7L1, and TGFB3) were associated with resistance to erlotinib.
[Novel methylation and expression markers associated with breast cancer].
In Mol Biol (mosk), 2007
Seven genes undergoing abnormal epigenetic regulation in breast cancer, SEMA6B, BIN1, VCPIP1, LAMC3, KCNH2, CACNG4 and PSMF1, have been identified by this method.
Quantitative trait locus that determines the cross-sectional shape of the femur in SAMP6 and SAMP2 mice.
Kyoto, Japan. In J Bone Miner Res, 2007
The Pbd1 locus was successfully narrowed down to a 10.0-Mbp region, and the expression analysis suggested a candidate gene, Cacng4.
A targeted mutation in Cacng4 exacerbates spike-wave seizures in stargazer (Cacng2) mice.
Bar Harbor, United States. In Proc Natl Acad Sci U S A, 2005
The voltage-dependent calcium channel gamma4 subunit protein, CACNG4, is closely related to the gamma2 subunit, CACNG2.
Human neuronal stargazin-like proteins, gamma2, gamma3 and gamma4; an investigation of their specific localization in human brain and their influence on CaV2.1 voltage-dependent calcium channels expressed in Xenopus oocytes.
GeneRIF
London, United Kingdom. In Bmc Neurosci, 2003
examined distribution of the stargazin-like proteins gamma2, gamma3, and gamma4 in human CNS: gamma2 is expressed in cerebellum, cerebral cortex, hippocampus and thalamus, whereas gamma3 abounds in cerebral cortex & amygdala and gamma4 in basal ganglia
Identification and characterization of a calcium channel gamma subunit expressed in differentiating neurons and myoblasts.
Pasadena, United States. In Dev Biol, 2002
Here, we describe the chick gamma4 regulatory subunit (CACNG4), the first such subunit to be characterized in early development.
A cluster of three novel Ca2+ channel gamma subunit genes on chromosome 19q13.4: evolution and expression profile of the gamma subunit gene family.
Houston, United States. In Genomics, 2001
The existence of an extended family of gamma subunits was subsequently demonstrated upon identification of CACNG2 (22q13), CACNG3 (16p12-p13), and CACNG4 and CACNG5 (17q24).
Identification of three novel Ca(2+) channel gamma subunit genes reveals molecular diversification by tandem and chromosome duplication.
Houston, United States. In Genome Res, 1999
Low-stringency genomic sequence analysis of targeted regions led to the identification of three novel Ca(2+) channel gamma subunit genes, CACNG3, CACNG4, and CACNG5, on chromosomes 16 and 17.
