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Calcium channel, voltage-dependent, alpha 2/delta subunit 3
CACNA2D3, alpha2delta-3, calcium channel, voltage-dependent, alpha2/delta subunit 3, calcium channel alpha2delta-3 subunit
This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008] (from
NCBI)
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CAN, HAD, OUT, AGE, POLYMERASE
Papers on
CACNA2D3
Genetic contribution to iron status: SNPs related to iron deficiency anaemia and fine mapping of CACNA2D3 calcium channel subunit.
New
Madrid, Spain. In Blood Cells Mol Dis, Dec 2015
Novel SNP rs1375515, located in a subunit of the calcium channel gene CACNA2D3, is associated with a higher risk of anaemia.
Identification of differential splicing genes in gliomas using exon expression profiling.
New
Hangzhou, China. In Mol Med Report, Feb 2015
Furthermore, screening with a defined threshold identified 6 genes that were highly expressed in GBM, including AFF2, CACNA2D3 and ARPP21, while the 6 highly expressed genes in OD notably included CNTN2.
Genetic association analysis using weighted false discovery rate approach on Genetic Analysis Workshop 18 data.
Toronto, Canada. In Bmc Proc, 2013
Using the real genetic and phenotype data of chromosome 3 from Genetic Analysis Workshop 18, 1 SNP from gene CACNA2D3 was found to have significant association with mean arterial pressure.
Influence of diet, menstruation and genetic factors on iron status: a cross-sectional study in Spanish women of childbearing age.
Madrid, Spain. In Int J Mol Sci, 2013
Five selected SNPs were genotyped: rs3811647, rs1799852 (Tf gene); rs1375515 (CACNA2D3 gene); and rs1800562 and rs1799945 (HFE gene, mutations C282Y and H63D, respectively).
Comparing baseline and longitudinal measures in association studies.
Boston, United States. In Bmc Proc, 2013
The gene CACNA2D3, identified by both longitudinal and baseline approaches, had a stronger signal in the longitudinal analysis (p = 2.65 × 10(-7)) compared to that in the baseline analysis (p = 2.48 × 10(-5)).
Characterization of CACNA2D3 as a putative tumor suppressor gene in the development and progression of nasopharyngeal carcinoma.
Hong Kong, Hong Kong. In Int J Cancer, 2013
Herein, we characterized a novel candidate tumor suppressor gene (TSG) CACNA2D3, a voltage-dependent subunit alpha 2 delta 3 of a calcium channel complex.
Investigation of tumor suppressing function of CACNA2D3 in esophageal squamous cell carcinoma.
Guangzhou, China. In Plos One, 2012
In this study, one TSG, CACNA2D3 at 3p21.1, was characterized.
Identification of a novel quantitative trait nucleotype related to iron status in a calcium channel gene.
Madrid, Spain. In Dis Markers, 2012
The rs1375515, located in an intronic region of the calcium channel gene CACNA2D3, showed strong associations with levels of mean corpuscular volume according to BMA test, and with levels of haemoglobin and ferritin according to decision trees.
Methylation of the calcium channel regulatory subunit α2δ-3 (CACNA2D3) predicts site-specific relapse in oestrogen receptor-positive primary breast carcinomas.
GeneRIF
London, United Kingdom. In Br J Cancer, 2012
Expression of CACNA2D3 mRNA is regulated in breast cancer cell lines by methylation in the CpG island located in the 5' regulatory region of the gene.
Integration of global spectral karyotyping, CGH arrays, and expression arrays reveals important genes in the pathogenesis of glioblastoma multiforme.
GeneRIF
Salamanca, Spain. In Ann Surg Oncol, 2012
High CACNA2D3 gene expression is assiciated with glioblastoma multiforme.
Contractility of ventricular myocytes is well preserved despite altered mechanisms of Ca2+ transport and a changing pattern of mRNA in aged type 2 Zucker diabetic fatty rat heart.
Al `Ayn, United Arab Emirates. In Mol Cell Biochem, 2012
Myh6, Tnnt2, Cacna2d3, Slc9a1, and Atp2a2 were downregulated while Myl2, Cacna1g, Cacna1h, and Atp2a1 were upregulated in ZDF ventricle compared to controls.
Characterization of cytarabine-resistant leukemic cell lines established from five different blood cell lineages using gene expression and proteomic analyses.
Fukui, Japan. In Int J Oncol, 2011
The DNA microarray analysis revealed eight genes (C19orf2, HSPA8, LGALS1, POU4F3, PSAP, AKT1, MBC2 and CACNA2D3) that were altered in all five ara-C-resistant lines compared to parental cells.
A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene.
Impact
GeneRIF
Vienna, Austria. In Cell, 2010
Mice mutant for the stj ortholog CACNA2D3 (alpha2delta3) exhibit impaired behavioral heat pain sensitivity.
Methylation of the calcium channel-related gene, CACNA2D3, is frequent and a poor prognostic factor in gastric cancer.
GeneRIF
Tokyo, Japan. In Gastroenterology, 2008
Loss of CACNA2D3 expression through aberrant promoter hypermethylation may contribute to gastric carcinogenesis.
Extensive molecular genetic analysis of the 3p14.3 region in patients with Zimmermann-Laband syndrome.
GeneRIF
Hamburg, Germany. In Am J Med Genet A, 2007
did not detect submicroscopic deletion or duplication nor sequence alteration in either CACNA2D3 or WNT5A in ZLS-affected individuals
Voltage-dependent calcium channels.
Review
Bratislava, Slovakia. In Gen Physiol Biophys, 2005
Two new alpha2delta subunits, alpha2delta-2 and alpha2delta-3, regulate all classes of HVA calcium channels.
Low voltage activated calcium channels: from genes to function.
Review
München, Germany. In Gen Physiol Biophys, 2000
In contrast, alpha2delta-1, alpha2delta-3, gamma-2 and gamma-4 subunits failed to modulate the current or had only minor effects.
