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Calcium channel, voltage-dependent, alpha 2/delta subunit 2

This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Flu, NPRL2, WAVE, TSG
Papers on CACNA2D2
Photoreversible [2] Catenane via the Host-Guest Interactions between a Palladium Metallacycle and β-Cyclodextrin.
Stang et al., Shanghai, China. In Inorg Chem, Jan 2016
We report the efficient preparation of an A2D2 (A = acceptor and D = donor) metallacycle 2 = [(en)2Pd2(1)2](NO3)4, using the coordination driven self-assembly of trans-azobenzene based bispyridyl ligand 1 and (en)Pd(NO3)2 (en = ethylenediamine).
CACNA2D2 promotes tumorigenesis by stimulating cell proliferation and angiogenesis.
Mariot et al., Villeneuve-d'Ascq, France. In Oncogene, Nov 2015
In the present study, we have assessed whether a putative calcium channel α2δ2 auxiliary subunit (CACNA2D2 gene) could be involved in prostate cancer (PCA) progression.
Increased sensitivity to kindling in mice lacking TSP1.
Porter et al., Stanford, United States. In Neuroscience, Nov 2015
Decreased CACNA2D2 mRNA was only detected in mice that lacked TSP1 and α2δ-1/2 protein levels in the cortex were lower in the TSP 1/2 KO mice.
Neomorphic effects of recurrent somatic mutations in Yin Yang 1 in insulin-producing adenomas.
Lifton et al., Uppsala, Sweden. In Proc Natl Acad Sci U S A, May 2015
Genes showing large increases in expression in YY1(T372R) tumors included ADCY1 (an adenylyl cyclase) and CACNA2D2 (a Ca(2+) channel); both are expressed at very low levels in normal β-cells and show mutation-specific YY1 binding sites.
A voltage-gated calcium channel regulates lysosomal fusion with endosomes and autophagosomes and is required for neuronal homeostasis.
Tong et al., Hangzhou, China. In Plos Biol, Mar 2015
The role of VGCC in AV-lysosomal fusion is evolutionarily conserved, as the loss of the mouse homologues, Cacna1a and Cacna2d2, also leads to autophagic defects in mice.
The lung-specific proteome defined by integration of transcriptomics and antibody-based profiling.
Micke et al., Uppsala, Sweden. In Faseb J, 2014
Transcript levels of 10 genes (SFTPB, SFTPC, SFTPD, SLC34A2, LAMP3, CACNA2D2, AGER, EMP2, NKX2-1, and NAPSA) were significantly associated with survival in the adenocarcinoma subgroup, thus qualifying as promising biomarker candidates.
A review of the role of genetic testing in pain medicine.
Faynboym et al., Indianapolis, United States. In Pain Physician, 2014
METHODS: This article discusses the specific pain implications of genetic variations in CYP1A2, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4, CYP3A7, OPRM1, OPRK1, OPRD1, COMT, GABA, UGT, MC1R, GCH1, ABCB1, P-glycoprotein, 5HTR1A, 5HTR2A, MTHFR, CACNA2D2, and 5-HTTLPR.
Validation and target gene screening of hsa-miR-205 in lung squamous cell carcinoma.
Lu et al., Shanghai, China. In Chin Med J (engl), 2013
Ten target genes (ACSL1, AXIN2, CACNA2D2, FOXO3, PPP1R3A, PRKAG3, RUNX1, SMAD4, STK3 and TBL1XR1) were significantly down-regulated in SQ and had a strong negative correlation with miR-205, while one target gene (CDH3) was up-regulated in SQ and exhibited a strong positive correlation with miR-205.
Differences in human cortical gene expression match the temporal properties of large-scale functional networks.
Mesmoudi et al., Paris, France. In Plos One, 2013
Ionic channels and release-related proteins more expressed in the VSA ring favor temporal precision of fast evoked neural transmission (Sodium channels SCNA1, SCNB1 potassium channel KCNA1, calcium channel CACNA2D2, Synaptotagmin SYT2, Complexin CPLX1, Synaptobrevin VAMP1).
Alterations of RASSF1A in premalignant cervical lesions: clinical and prognostic significance.
Panda et al., Calcutta, India. In Mol Carcinog, 2012
CACNA2D2 deletion/methylation is associated with cervical disease progression.
The alpha2delta subunits of voltage-gated calcium channels form GPI-anchored proteins, a posttranslational modification essential for function.
Dolphin et al., London, United Kingdom. In Proc Natl Acad Sci U S A, 2010
all of the alpha(2)delta subunits studied, alpha(2)delta-1, alpha(2)delta-2, and alpha(2)delta-3, show all of the properties expected of glycosylphosphatidylinositol-anchored proteins, both when heterologously expressed and in native tissues.
Evaluation of the 3p21.3 tumour-suppressor gene cluster.
Latif et al., Dundee, United Kingdom. In Oncogene, 2007
The candidate genes are HYAL2, FUS1, Ras-associated factor 1 (RASSF1), BLU/ZMYND10, NPR2L, 101F6, PL6 and CACNA2D2.
The ducky(2J) mutation in Cacna2d2 results in reduced spontaneous Purkinje cell activity and altered gene expression.
Dolphin et al., London, United Kingdom. In J Neurosci, 2006
Although transgenic du(2J)/+ mice have a marked reduction in alpha2delta-2 protein, they show no fall in Purkinje somatic calcium currents or increase in cerebellar tyrosine hydroxylase gene expression.
The calcium channel alpha2delta-2 subunit partitions with CaV2.1 into lipid rafts in cerebellum: implications for localization and function.
Dolphin et al., London, United Kingdom. In J Neurosci, 2006
Both alpha2delta-2 and CaV2.1 are normally associated with cholesterol-rich microdomains, and this influences their functionality.
Cerebellar ataxia, seizures, premature death, and cardiac abnormalities in mice with targeted disruption of the Cacna2d2 gene.
Lerman et al., Frederick, United States. In Am J Pathol, 2004
In mice, targeted disruption of Cacna2d2 led to growth retardation, reduced life span, ataxia, enhanced susceptibility to seizures, and cardiac abnormalities. Cacna2d2 may be involved in hereditary cerebellar ataxias and epileptic disorders in humans.
[New tumor suppressor genes in hot spots of human chromosome 3: new methods of identification].
Zabarovskiĭ et al., Moscow, Russia. In Mol Biol (mosk), 2003
Numerous attempts to find mutations in exons of silent genes failed, and at least half of the new candidate genes (RASSFIA, CACNA2D2, BLU, HYAL1, SEMA3B, RAR-beta) proved to be inactivated by promoter methylation.
Mechanisms of cell reproductive death and shapes of radiation dose--survival curves of mammalian cells.
Barendsen, Rijswijk, Netherlands. In Int J Radiat Biol, 1990
It is based on the analysis of shapes of survival curves in terms of S(D)/S(O) = exp - (a1D + a2D2) and the suggestion that paired dsb in DNA, produced within distances of the order of 10 nm, are efficient in initiating the sequence of events causing cell reproductive death by individual particle tracks.
A reexamination of the diploidlike meiotic behavior of polyploid cotton.
Endrizzi et al., Tucson, United States. In Theor Appl Genet, 1976
Chromosome associations at pachytene, diakinesis, and metaphase I were analyzed in haploids of the allotetraploid G.hirsutwn, in the F1 hybrid between G.arboreum (A2) and G. raimondii (D5), and in the doubled hybrid 2(A2D2) in an effort to define more clearly the mechanism responsible for the diploidlike behavior of the natural allotetraploids.
The Voltage-Gated Calcium Channel and Absence Epilepsy
Noebels, Bethesda, United States. In Unknown Journal, 0001
The regulatory calcium subunit genes Cacnb4 and Cacna2d2 are expressed in overlapping patterns, and their loss causes a similar phenotype.
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