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Chloride channel accessory 1

This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, V1a, Cystic Fibrosis Transmembrane Conductance Regulator, HAD
Papers using CACC antibodies
Structural insights into ChpT, an essential dimeric histidine phosphotransferase regulating the cell cycle in Caulobacter crescentus
Villeret Vincent et al., In Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 2011
... ), was amplified using the primers pCC3470-CACC-fw (5′-CACCTTGACCGAGACCGTCACC-3′) and pCC3470-rev (5′-GGTTAAGGAGCGGTTTGCTA-3′) cloned into pENTR/D (Life Technologies, Carlsbad, California, USA) using ...
Papers on CACC
Effects of new generation cacc ano1 inhibitors on slow waves in the gastrointestinal tract.
Ward et al., Reno, United States. In Br J Pharmacol, Feb 2016
generation small-molecule calcium-activated chloride channel (CaCC Ano1) inhibitors.
Activation of Ca(2+) -activated Cl(-) channel ANO1 by localized Ca(2+) signals.
Gamper et al., Shijiazhuang, China. In J Physiol, Feb 2016
Anoctamin-1 (ANO1, TMEM16A) is a principal CaCC subunit in many cell types, yet our understanding of the mechanisms of ANO1 activation and regulation are only beginning to emerge.
Expressional profiles of transcription factors in the progression of Helicobacter pylori-associated gastric carcinoma based on protein/DNA array analysis.
Jiang et al., Changsha, China. In Med Oncol, Dec 2015
The data demonstrated the up-regulated TFs such as GATA-3, AP4, c-Myc and Pbx1 in the gastric mucosa of GC patients compared with the healthy volunteers, while other TFs, particularly CCAAT and CACC, showed the consistently decreasing trend along the gastric carcinogenesis.
Mechanism of allosteric activation of TMEM16A/ANO1 channels by a commonly used chloride channel blocker.
Tammaro et al., Oxford, United Kingdom. In Br J Pharmacol, Dec 2015
TMEM16A encodes a CaCC.
CLCA1 and TMEM16A: the link towards a potential cure for airway diseases.
Brett, Saint Louis, United States. In Expert Rev Respir Med, Oct 2015
The hallmark traits of chronic obstructive airway diseases are inflammation, airway constriction due to hyperreactivity and mucus overproduction.
Molecular and functional significance of Ca(2+)-activated Cl(-) channels in pulmonary arterial smooth muscle.
Greenwood et al., Reno, United States. In Pulm Circ, Jun 2015
It is permeable to Cl(-) and is activated by a rise in intracellular Ca(2+) concentration (Ca(2+)-activated Cl(-) channel, or CaCC).
The role of Ca(2+) activated Cl(-) channels in blood pressure control.
Aalkjaer et al., Århus, Denmark. In Curr Opin Pharmacol, Apr 2015
Changes in CaCC expression are shown in association with hypertension, kidney cysts, sudden cardiac death and arrhythmias.
Structure and insights into the function of a Ca(2+)-activated Cl(-) channel.
Long et al., New York City, United States. In Nature, 2015
Representing, to our knowledge, the first structure of a CaCC, the eukaryotic BEST1 channel, which recapitulates CaCC function in liposomes, is formed from a pentameric assembly of subunits.
Novel Roles for Chloride Channels, Exchangers, and Regulators in Chronic Inflammatory Airway Diseases.
Brett et al., Saint Louis, United States. In Mediators Inflamm, 2014
In this review, we focus on the emerging novel roles for a chloride channel regulator (CLCA1), a calcium-activated chloride channel (TMEM16A), and two chloride exchangers (SLC26A4/pendrin and SLC26A9) in chronic inflammatory airway diseases.
Genetic disruption of Ano5 in mice does not recapitulate human ANO5-deficient muscular dystrophy.
Han et al., Columbus, United States. In Skelet Muscle, 2014
BACKGROUND: Anoctamin 5 (ANO5) is a member of a conserved gene family (TMEM16), which codes for proteins predicted to have eight transmembrane domains and putative Ca(2+)-activated chloride channel (CaCC) activity.
Identification of the Novel TMEM16A Inhibitor Dehydroandrographolide and Its Anticancer Activity on SW620 Cells.
Zhang et al., Changchun, China. In Plos One, 2014
TMEM16A, a calcium-activated chloride channel (CaCC), is highly amplified and expressed in human cancers and is involved in the growth and metastasis of some malignancies.
TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation.
Jan et al., San Francisco, United States. In Cell, 2012
Heterologous expression of TMEM16F generates a small-conductance Ca(2+)-activated nonselective cation (SCAN) current with subpicosiemens single-channel conductance rather than a CaCC.
Loss of breast epithelial marker hCLCA2 promotes epithelial-to-mesenchymal transition and indicates higher risk of metastasis.
Elble et al., Springfield, United States. In Oncogene, 2012
hCLCA2 is required for epithelial differentiation, and its loss during tumor progression contributes to metastasis.
CLCA2 as a p53-inducible senescence mediator.
Matsuda et al., Tokyo, Japan. In Neoplasia, 2012
the reduced expression of CLCA2 was frequently observed in various kinds of cancers including prostate cancer
Lymphatic endothelial murine chloride channel calcium-activated 1 is a ligand for leukocyte LFA-1 and Mac-1.
Ruddell et al., Seattle, United States. In J Immunol, 2010
murine chloride channel calcium-activated was discovered to be a lymphatic endothelial surface ligand for LFA-1 and Mac-1
Effect of Th2 type cytokines on hCLCA1 and mucus expression in cystic fibrosis airways.
Hamid et al., Germany. In J Cyst Fibros, 2010
in cultured nasal airway cells, Th2 type cytokines increased hCLCA1 (calcium-activated chloride channel 1) expression in Cystic Fibrosis patients but not mucus expression
[Expression and clinical significance of calcium-activated chloride channel and mucins in nasal mucosa with allergic rhinitis].
Wang et al., Wuhan, China. In Lin Chuang Er Bi Yan Hou Ke Za Zhi, 2010
Increased expression of hCLCA1 in allergic rhinitis was correlated with the expression of MUC5AC.
Expression cloning of TMEM16A as a calcium-activated chloride channel subunit.
Jan et al., San Francisco, United States. In Cell, 2008
Using Axolotl oocytes as an expression system, we have identified TMEM16A as the Xenopus oocyte CaCC.
Structure and function of CLCA proteins.
Forsyth et al., Saskatoon, Canada. In Physiol Rev, 2005
The isoform with disrupted beta4-integrin binding (hCLCA1, pCLCA1, mCLCA3) alters epithelial mucus secretion and ion transport processes.
Anion transport in heart.
Horowitz et al., Reno, United States. In Physiol Rev, 2000
I(Cl.Ca), and I( (ClC-3, CLCA1, and ClC-2, respectively) have recently been identified and are presently being evaluated.
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