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CABP5 calcium binding protein 5

The product of this gene belongs to a subfamily of calcium binding proteins, which share similarity to calmodulin. Calcium binding proteins are an important component of calcium mediated cellular signal transduction. Expression of this gene is retina-specific. The mouse homolog of this protein has been shown to express in the inner nuclear layer of the retina, suggested its role in neuronal functioning. The specific function of this gene is unknown. [provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: ROD, Chx10, CaM, CAN, annexin IV
Papers on CaBP5
Requirement for the paired-like homeodomain transcription factor VSX1 in type 3a mouse retinal bipolar cell terminal differentiation.
Chow et al., Victoria, Canada. In J Comp Neurol, 2012
This observation was unexpected given previous findings that Cabp5 immunolabeling of type 3 bipolar cell axon terminals is reduced in Vsx1-null mice.
A transgenic mouse line expressing cre recombinase in undifferentiated postmitotic mouse retinal bipolar cell precursors.
Chow et al., Victoria, Canada. In Plos One, 2010
The appearance of Cre-immunolabeled cells preceded the expression of bipolar cell type-specific markers such as PKCĪ± and Cabp5 suggesting that transgene expression is initiated prior to terminal differentiation.
Insight into the role of Ca2+-binding protein 5 in vesicle exocytosis.
Haeseleer et al., Seattle, United States. In Invest Ophthalmol Vis Sci, 2010
This study shows that CaBP5 interacts with Munc18-1 and myosin VI, two proteins involved in the synaptic vesicle cycle stimulating neurite outgrowth and vesicle exocytosis
Characterization of Ca2+-binding protein 5 knockout mouse retina.
Haeseleer et al., Seattle, United States. In Invest Ophthalmol Vis Sci, 2008
PURPOSE: The goal of this study was to investigate, with the use of CaBP5 knockout mice, whether Ca(2+)-binding protein 5 (CaBP5) is required for vision.
A core paired-type and POU homeodomain-containing transcription factor program drives retinal bipolar cell gene expression.
Cepko et al., Boston, United States. In J Neurosci, 2008
Using in vivo retinal DNA transfection and reporter gene constructs, a 200 bp Grm6 enhancer sequence, a 445 bp Cabp5 promoter sequence, and a 164 bp Chx10 enhancer sequence, were defined, each driving reporter expression specifically in distinct but overlapping bipolar cell subtypes.
Ca2+ binding protein-1 inhibits Ca2+ currents and exocytosis in bovine chromaffin cells.
Pan et al., Taipei, Taiwan. In J Biomed Sci, 2008
Neuronal Ca2+ sensor-1 and CaBP5, both are calmodulin-like proteins, did not affect N(+, Ca2+ currents, and exocytosis.
Ca2+-binding proteins tune Ca2+-feedback to Cav1.3 channels in mouse auditory hair cells.
Lee et al., Atlanta, United States. In J Physiol, 2008
Of multiple CaBPs detected in inner hair cells (CaBP1, CaBP2, CaBP4 and CaBP5), CaBP1 most efficiently blunts Ca(2+)-dependent inactivation of Ca(v)1.3.
Decreased platelet expression of myosin regulatory light chain polypeptide (MYL9) and other genes with platelet dysfunction and CBFA2/RUNX1 mutation: insights from platelet expression profiling.
Rao et al., Philadelphia, United States. In J Thromb Haemost, 2007
Genes downregulated > or = 5-fold include those involving calcium binding proteins (CABP5), ion transport (sodium/potassium/Ca exchanger, SLC24A3), cytoskeletal/microtubule proteins (erythrocyte membrane protein band 4.1-like 3, EPB41L3; tropomyosin 1, TPM1; tubulin, alpha 1, TUBA1), signaling proteins (RAB GTPase activating protein 1-like, RABGAP1L; beta3-endonexin, ITGB3 BP) and chemokines (platelet factor 4 variant 1, PF4V1; chemokine CXCL5, CXCL5).
Five members of a novel Ca(2+)-binding protein (CABP) subfamily with similarity to calmodulin.
Palczewski et al., Seattle, United States. In J Biol Chem, 2000
Expression of CaBP5, for example, is restricted to retinal rod and cone bipolar cells.
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