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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Carbonic anhydrase XIV

CA XIV, CA14, Carbonic anhydrase XIV
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XIV is predicted to be a type I membrane protein and shares highest sequence similarity with the other transmembrane CA isoform, CA XII; however, they have different patterns of tissue-specific expression and thus may play different physiologic roles. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CARP, HAD, CAN, CA IV
Papers on CA XIV
Fluorescent sulfonamide carbonic anhydrase inhibitors incorporating 1,2,3-triazole moieties: Kinetic and X-ray crystallographic studies.
Supuran et al., Sesto Fiorentino, Italy. In Bioorg Med Chem, Feb 2016
and CA XIV (KIs of 12.8-53.6nM).
[Analysis on the change of genotype of enteroviruses associated hand, foot and mouth disease in Beijing during 2013 to 2014].
Zhu et al., In Zhonghua Er Ke Za Zhi, Aug 2015
Twenty six of the 89 other EVs included CA2, CA5, CA8, CA9, CA12, CA14, CB2, CB5, E6, E9 and E25, each genotype of which was no more than 3.
IFNG+874A/T polymorphisms and IFNG CA repeat polymorphism associated with asthma in Asian--a meta-analysis.
Li et al., Huainan, China. In J Asthma, 2014
RESULTS: The differences between IFNG polymorphism and the susceptibility to asthma may vary across ethnicities and ages, and also that the allelic frequencies of the AA genotypes in IFNG at +874 is associated with an increased risk of asthma in the Chinese Han adult population; additionally, CA14 occurrence in the first intron can increase the risk of asthma in the Japanese population.
Inhibition of mammalian carbonic anhydrases I-XIV with grayanotoxin III: solution and in silico studies.
Supuran et al., Calgary, Canada. In J Enzyme Inhib Med Chem, 2014
The structural comparison between membrane-associated human carbonic anhydrases provides insights into drug design of selective inhibitors.
De Simone et al., Napoli, Italy. In Biopolymers, 2014
Carbonic anhydrase isoform XIV (CA XIV) is the last member of the human (h) CA family discovered so far, being localized in brain, kidneys, colon, small intestine, urinary bladder, liver, and spinal cord.
Extracellular DNA release confers heterogeneity in Candida albicans biofilm formation.
Ramage et al., Glasgow, United Kingdom. In Bmc Microbiol, 2013
The biofilm biomass and eDNA release by single (∆cht2, ∆cht3) and double knockout (∆cht2/∆cht3) chitinase mutants were significantly less compared to their parental strain CA14, confirming the role of chitinases in eDNA release and biofilm formation.
Expression patterns and subcellular localization of carbonic anhydrases are developmentally regulated during tooth formation.
Gritli-Linde et al., Göteborg, Sweden. In Plos One, 2013
While CAIV, CAVI/Car6, CAIX, CARPXI and CAXIV were produced by all odontoblasts, CAIII distribution displayed a striking asymmetry, in that it was virtually confined to odontoblasts in the root of molars and root analog of incisors.
Regulation of zinc transporter 3 and carbonic anhydrases 2 and 14 mRNA expression in the retina of rats affected by low dietary zinc.
Qin et al., Nanjing, China. In Genet Mol Res, 2013
The expression of ZnT-3, carbonic anhydrase 2 (CA2) and 14 (CA14) were detected by RT-PCR.
Aspergillus flavus VelB acts distinctly from VeA in conidiation and may coordinate with FluG to modulate sclerotial production.
Ehrlich et al., New Orleans, United States. In Fungal Genet Biol, 2013
Deletion of velB in A. flavus CA14 severely impaired conidiation in the dark although to a lesser extent than deletion of veA.
Synthesis and carbonic anhydrase inhibitory properties of sulfamides structurally related to dopamine.
Supuran et al., Erzurum, Turkey. In Bioorg Med Chem, 2013
that is, CA I, CA II, CA VA, CA IX, CA XII and CA XIV, and two β-CAs from Candida glabrata (CgCA) and Mycobacterium tuberculosis (Rv3588) with these sulfamides was investigated.
Carbonic anhydrase XIV in the normal and hypertrophic myocardium.
Alvarez et al., La Plata, Argentina. In J Mol Cell Cardiol, 2012
CAXIV functionally interacts with AE3, forming an extracellular membrane protein complex involved in the regulation of bicarbonate metabolism and pHi in the heart.
Searching for novel intercellular signal-transducing molecules in the kidney and their clinical application.
Nakao et al., Kyoto, Japan. In Clin Exp Nephrol, 2010
In this review, isolation and characterization of several kidney-derived molecules are described, namely carbonic anhydrase XIV, cysteine-rich protein 61, and kidney-liver-specific immunoglobulin-like protein.
Identification of 3,4-Dihydroisoquinoline-2(1H)-sulfonamides as potent carbonic anhydrase inhibitors: synthesis, biological evaluation, and enzyme--ligand X-ray studies.
Chimirri et al., Messina, Italy. In J Med Chem, 2010
Results indicate that some derivatives showed potent hCA IX and hCA XIV inhibitory effects at nanomolar concentrations as well as low affinity for the ubiquitous hCA II.
Bicarbonate homeostasis in excitable tissues: role of AE3 Cl-/HCO3- exchanger and carbonic anhydrase XIV interaction.
Alvarez et al., Edmonton, Canada. In Am J Physiol Cell Physiol, 2009
Association of AE3 and CAXIV may represent a mechanism to enhance disposal of waste CO(2) and to balance pH in excitable tissues.
Carbonic anhydrases CA4 and CA14 both enhance AE3-mediated Cl--HCO3- exchange in hippocampal neurons.
Chesler et al., New York City, United States. In J Neurosci, 2009
CA XIV (along with carbonic anhydrase 4) plays an important role in the regulation of intracellular pH in hippocampus, via facilitation of anion exchanger AE3-mediated chloride-bicarbonate antiporter HCO3 exchange.
Familial pure proximal renal tubular acidosis--a clinical and genetic study.
Holtzman et al., H̱olon, Israel. In Nephrol Dial Transplant, 2008
No mutation was found in the coding regions and intron-exon boundaries of the genes for CA II, CA IV, CA XIV, kNCB1, NHE3, NHE8, NHRF1, NHRF2 and SLC26A6 amplified from genomic DNA of family members with pRTA.
Carbonic anhydrases as targets for medicinal chemistry.
Scozzafava et al., Sesto Fiorentino, Italy. In Bioorg Med Chem, 2007
Some of them are cytosolic (CA I, CA II, CA III, CA VII, CA XIII), others are membrane-bound (CA IV, CA IX, CA XII, CA XIV and CA XV), CA VA and CA VB are mitochondrial, and CA VI is secreted in saliva and milk.
The role of carbonic anhydrases in renal physiology.
Schwartz et al., Rochester, United States. In Kidney Int, 2007
CAII and CAIV predominate in human and rabbit kidneys; in rodent kidneys, CAXII, and CAXIV are also present.
Characterization and inhibition of the recently discovered carbonic anhydrase isoforms CA XIII, XIV and XV.
Parkkila et al., Tampere, Finland. In Curr Top Med Chem, 2006
CA XIV is a membrane-bound enzyme that is expressed in numerous organs such as the brain, kidney, eye, liver and epididymis, where it has a role in the regulation of acid-base balance.
Carbonic anhydrases as drug targets--an overview.
Supuran, Sesto Fiorentino, Italy. In Curr Top Med Chem, 2006
Some of these isozymes are cytosolic (CA I, CA II, CA III, CA VII, CA XIII), others are membrane-bound (CA IV, CA IX, CA XII, CA XIV and CA XV), CA VA and CA VB are mitochondrial, and CA VI is secreted in saliva and milk.
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