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Carbonic anhydrase VII

CA VII, CA7, carbonic anhydrase VII
Carbonic anhydrases are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. The cytosolic protein encoded by this gene is predominantly expressed in the salivary glands. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, CARP, fibrillin-1
Papers on CA VII
Inhibition of carbonic anhydrase isoforms I, II, IV, VII and XII with carboxylates and sulfonamides incorporating phthalimide/phthalic anhydride scaffolds.
Supuran et al., Riyadh, Saudi Arabia. In Bioorg Med Chem, Feb 2016
They were synthesized from substituted anthranilic acids and trimellitic anhydride chloride, followed by reaction with primary amines and were tested for the inhibition of five physiologically relevant CA isoforms, the human (h) hCA I, II, IV, VII and XII, some of which are involved in serious pathologies (CA II, IV and XII in glaucoma; CA VII in epilepsy; CA XII in some solid tumors).
Assessment of phytochemical composition and antioxidant potential in some indigenous chilli genotypes from North East India.
Prakash et al., Pāsighāt, India. In Food Chem, Jan 2016
Free radical scavenging activity using DPPH assay showed low IC50 ranging from 0.021 to 0.041 mg/mg, low EC50 from 0.92 to 1.78 mg/mg DPPH, high ARP values (56.17-109.52) in CHF-CA-6, CHF-CA-7, CHF-CA-17, CHF-CA-21, CHF-CA-22 and CHF-CA-23 genotypes.
Hit Recycling: Discovery of a Potent Carbonic Anhydrase Inhibitor by in Silico Target Fishing.
Botta et al., Siena, Italy. In Acs Chem Biol, Oct 2015
Most notably, GV2-20 experienced a remarkable selectivity for CA2, CA7, CA9, and CA12, and its scaffold was never explored before as a chemotype for CA inhibition, thus becoming an interesting lead candidate for further development.
Functionalization of fluorinated benzenesulfonamides and their inhibitory properties toward carbonic anhydrases.
Matulis et al., Vilnius, Lithuania. In Chemmedchem, Apr 2015
Many such fluorinated benzenesulfonamides were found to be nanomolar inhibitors of CA II, CA VII, tumor-associated CA IX and CA XII, and CA XIII.
Intrinsic thermodynamics of trifluoromethanesulfonamide and ethoxzolamide binding to human carbonic anhydrase VII.
Matulis et al., Vilnius, Lithuania. In J Mol Recognit, Mar 2015
Therefore, CA VII is a potential antiepileptic and anticancer drug target.
Gene-expression analysis of a colorectal cancer-specific discriminatory transcript set on formalin-fixed, paraffin-embedded (FFPE) tissue samples.
Molnár et al., Budapest, Hungary. In Diagn Pathol, 2014
After quality and quantity measurements, gene expression analysis of a colorectal cancer-specific marker set with 11 genes (CA7, COL12A1, CXCL1, CXCL2, CHI3L1, GREM1, IL1B, IL1RN, IL8, MMP3, SLC5A7) was performed with array real-time PCR using Transcriptor First Strand cDNA Synthesis Kit (Roche) and RealTime ready assays on LightCycler480 System (Roche).
Prognostic value of carbonic anhydrase VII expression in colorectal carcinoma.
Gao et al., Luoyang, China. In Bmc Cancer, 2014
Carbonic anhydrase VII (CA7), a member of the CA gene family, was recently demonstrated to be expressed in several human tissues including colon.
Ethylene bis-imidazoles are highly potent and selective activators for isozymes VA and VII of carbonic anhydrase, with a potential nootropic effect.
Ilies et al., Philadelphia, United States. In Chem Commun (camb), 2014
Biological testing on eight isozymes of carbonic anhydrase (CA) present in the human brain revealed compounds with nanomolar potency against CA VA and CA VII, also displaying excellent selectivity against other CA isozymes present in this organ.
Gene expression profiling of colorectal tumors and normal mucosa by microarrays meta-analysis using prediction analysis of microarray, artificial neural network, classification, and regression trees.
Chang et al., Taipei, Taiwan. In Dis Markers, 2013
Combining the results of four models, we found the top eight differential genes in CRCs; suppressor genes, CA7, SPIB, GUCA2B, AQP8, IL6R and CWH43; oncogenes, SPP1 and TCN1.
Carbonic anhydrases and brain pH in the control of neuronal excitability.
Kaila et al., Helsinki, Finland. In Subcell Biochem, 2013
Special attention is paid on the developmental expression patterns and actions of the neuronal isoform, CA VII.
Development and characterization of new monoclonal antibodies against human recombinant CA XII.
Zvirbliene et al., Vilnius, Lithuania. In Biomed Res Int, 2013
The majority of MAbs were highly specific to CA XII and did not cross-react with human recombinant CA I, CA II, CA VII, and CA XIII.
Mechanisms of suppression and enhancement of photocurrent/conversion efficiency in dye-sensitized solar-cells using carotenoid and chlorophyll derivatives as sensitizers.
Nagae et al., Sanda, Japan. In Molecules, 2011
In a set of retinoic-acid (RA) and carotenoic-acid (CA) sensitizers, having n conjugated double bonds, CA7 gave rise to the highest performance, which was reduced toward RA5 and CA13.
Carbonic anhydrases in the mouse harderian gland.
Parkkila et al., Tampere, Finland. In J Mol Histol, 2010
Car2, Car3, Car7, and Car15 mRNAs were barely within the detection limits in the mouse harderian gland.
Analysis of a shortened form of human carbonic anhydrase VII expressed in vitro compared to the full-length enzyme.
Parkkila et al., Tampere, Finland. In Biochimie, 2010
conclude that the full-length CA VII is a predominant active form in human brain and also in other tissues. In addition to the brain, CA VII is expressed in several other organs including the stomach, duodenum, colon, liver, and skeletal muscle
Diuretics: from classical carbonic anhydrase inhibitors to novel applications of the sulfonamides.
Supuran, Sesto Fiorentino, Italy. In Curr Pharm Des, 2007
Some low nanomolar (or even subnanomolar) inhibitors against such isoforms were recently detected, such as metholazone against CA VII, XII and XIII, chlorthalidone against CA VB, VII, IX, XII and XIII, indapamide against CA VII, IX, XII and XIII, furosemide against CA I, II and XIV, and bumethanide against CA IX and XII.
Carbonic anhydrases as targets for medicinal chemistry.
Scozzafava et al., Sesto Fiorentino, Italy. In Bioorg Med Chem, 2007
Some of them are cytosolic (CA I, CA II, CA III, CA VII, CA XIII), others are membrane-bound (CA IV, CA IX, CA XII, CA XIV and CA XV), CA VA and CA VB are mitochondrial, and CA VI is secreted in saliva and milk.
Carbonic anhydrases as drug targets--an overview.
Supuran, Sesto Fiorentino, Italy. In Curr Top Med Chem, 2006
Some of these isozymes are cytosolic (CA I, CA II, CA III, CA VII, CA XIII), others are membrane-bound (CA IV, CA IX, CA XII, CA XIV and CA XV), CA VA and CA VB are mitochondrial, and CA VI is secreted in saliva and milk.
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.
Supuran et al., Sesto Fiorentino, Italy. In Bioorg Med Chem Lett, 2005
these data furnish further evidence that hCA VII is the isozyme responsible for the anticonvulsant/antiepileptic activity of sulfonamides and sulfamates
Two developmental switches in GABAergic signalling: the K+-Cl- cotransporter KCC2 and carbonic anhydrase CAVII.
Kaila et al., Helsinki, Finland. In J Physiol, 2005
GABAergic transmission is influenced by the neuronal expression of carbonic anhydrase cavii--REVIEW
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