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Complement component 8, beta polypeptide

C8 beta is one of the three subunits that comprise the component 8 (C8) of the complement system. C8 participates in the formation of Membrane Attack Complex that results in the lysis of cells. Patients with C8B deficiency are prone to bacteria infection. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: C8A, CAN, OUT, Phosphoglucomutase, SIMPLE
Papers on C8B
Susceptibility to invasive meningococcal disease: polymorphism of complement system genes and Neisseria meningitidis factor H binding protein.
Hughes et al., Belfast, United Kingdom. In Plos One, 2014
RESULTS: Rs12085435 A in C8B was associated with odds ratio (OR) of IMD (0.35 [95% CI 0.19-0.67];
Structural requirements of strigolactones for germination induction and inhibition of Striga gesnerioides seeds.
Sugimoto et al., Kōbe, Japan. In Plant Cell Rep, 2013
Strigolactones with the same configuration at C3a, C8b and C2' as that in 5-deoxystrigol (9a) induced high germination of S. hermonthica seeds, but most of them inhibited the germination of S. gesnerioides.
Myelin basic protein undergoes a broader range of modifications in mammals than in lower vertebrates.
Andrews et al., Ann Arbor, United States. In J Proteome Res, 2012
Other modifications found in bovine MBP include N-terminal acetylation in components C1, C2, and C3; oxidation of methionine 19 in all five components; all charge isomers having both a mono- and dimethylated (symmetric) arginine at position 106; deimination in arginines 23 and 47 found only in component C8b; deimination of arginine 96 and deamidation in glutamine 102 found in components C2, C3, C8a, and C8b; phosphorylation in threonine 97 restricted to charge components C2 and C3; deimination in arginine 161 only found in component C3; deamidation of glutamine 120 was only observed in C3.
Biodegradation of endosulfan and endosulfan sulfate by Achromobacter xylosoxidans strain C8B in broth medium.
Singh et al., Delhi, India. In Biodegradation, 2011
Out of the 8 isolated bacterial strains, strain C8B was found to be the most efficient endosulfan degrader, degrading 94.12% α-endosulfan and 84.52% β-endosulfan.
Coding polymorphisms in the genes of the alternative complement pathway and abdominal aortic aneurysm.
Hughes et al., Belfast, United Kingdom. In Int J Immunogenet, 2011
This study tested 49 single nucleotide polymorphisms, including common putatively functional polymorphisms, in the genes of the alternative complement cascade (CFH, CFB, CFD, CFI, properdin, CR1, CR1L, CR2, CD46, vitronectin, C3, C5, C6, C7, C8A, C8B, C8G and C9).
The three-way relationship of polymorphisms of porcine genes encoding terminal complement components, their differential expression, and health-related phenotypes.
Ponsuksili et al., Germany. In Bmc Proc, 2010
The terminal complement components (TCCs: C6, C7, C8A, C8B, and C9) are encoded by the genes C6, C7, C8A, C8B, C8G, and C9.
Involvement of the c-jun N-terminal kinases JNK1 and JNK2 in complement-mediated cell death.
Fishelson et al., Tel Aviv-Yafo, Israel. In Mol Immunol, 2009
Complement C5b-9 induce a JNK/Bid-dependent and JNK-independent necrotic cell death.
Molecular cloning of the terminal complement components C6 and C8beta of cartilaginous fish.
Nonaka et al., Tokyo, Japan. In Fish Shellfish Immunol, 2009
To clarify the evolutionary origin of TCCs, we performed degenerate RT-PCR and RACE analyses of the cartilaginous fish liver and identified the C6 gene from a shark, Mustelus manazo, and the C8B gene from a chimaera, Chimaera phantasma.
Mesomorphic properties of the neat enantiomers of a chiral pyramidic liquid crystal.
Zimmermann et al., Israel. In Phys Chem Chem Phys, 2009
The crown form of nona-octanoyloxy tribenzocyclononatriene (C8) with C(3) symmetry was prepared and separated into its enantiomers (C8A and C8B) by HPLC.
Response gene to complement 32 is required for C5b-9 induced cell cycle activation in endothelial cells.
Rus et al., Baltimore, United States. In Exp Mol Pathol, 2009
Cell cycle induction by C5b-9 in aortic endothelial cells is RGC-32 dependent and this is in part through regulation of Akt and growth factor release.
Functional studies of the MACPF domain of human complement protein C8alpha reveal sites for simultaneous binding of C8beta, C8gamma, and C9.
Sodetz et al., Columbia, United States. In Biochemistry, 2006
results indicate that the principal binding site for C9 lies within the MACPF domain of C8alpha; they also suggest this site and the binding sites for C8beta and C8gamma are distinct
Assignment of immune-related genes to the channel catfish, Ictalurus punctatus, genetic map.
Waldbieser et al., United States. In Anim Genet, 2005
Eighteen new genes, adenosine A1 receptor (ADORA1), complement component 4-beta (C4b), complement component 8-beta (C8b), chemokine ligand 19 (CCL19), chemokine ligand 21 (CCL21), chemokine ligand 25 (CCL25), chemokine receptor 2 (CCR2), chemokine receptor 5 (CCR5), chemokine receptor 4 (CCR4), chemokine receptor 7 (CCR7), chemokine receptor 9 (CCR9), interleukin 1-beta (IL1B), integrin II-beta (ITGB2), novel immune type receptor 2 (NITR2), novel immune type receptor 4 (NITR4), natural killer cell lysin (NKLYSIN), nucleotide excision repair (RAD23B) and tumour necrosis factor-alpha (TNF), were assigned to the channel catfish (Ictalurus punctatus) genetic linkage map.
Effects of nonylphenol on hepatic testosterone metabolism and the expression of acute phase proteins in winter flounder (Pleuronectes americanus): comparison to the effects of Saint John's Wort.
Chapman et al., El Paso, United States. In Comp Biochem Physiol C Toxicol Pharmacol, 2005
Quantitative real-time PCR (Q-PCR) confirmed 4-NP altered the expression of complement components C8b, cathepsin L, C-type lectin domain, FK506 binding protein 2 precursor (FKBP2) and an EST (expressed sequence tag).
Transcriptional analysis of human peripheral blood mononuclear cells after influenza immunization.
Giulivi et al., Ottawa, Canada. In J Clin Virol, 2004
With PHA, the genes TNF-R, CTSG, CD3 delta, C8B, CRF1 and CCR2 had higher expression compared with the viral antigen stimulation.
[Dedicated composite fillings--inlays].
Tihacek-Sojić et al., Belgrade, Serbia. In Vojnosanit Pregl, 2003
CONCLUSION: From the clinical point of view, purpose inlays from Herculite XRV lab C8B in combination with Opti Bond System and composite cement Porcelite Dual Cure showed high functional and esthetic values in the observational period of two years.
Role of the human C8 subunits in complement-mediated bacterial killing: evidence that C8 gamma is not essential.
Sodetz et al., Columbia, United States. In Mol Immunol, 2002
C8 alpha and C8 beta have correspondingly similar roles in MAC-mediated lysis of erythrocytes and bacterial killing. C8 gamma is not required for complement-mediated killing of Gram-negative bacteria.
Interaction between the C8 alpha-gamma and C8 beta subunits of human complement C8: role of the C8 beta N-terminal thrombospondin type 1 module and membrane attack complex/perforin domain.
Sodetz et al., Columbia, United States. In Biochemistry, 2002
The binding specificity between C8 beta and C8 alpha subunits is determined by a cooperative interaction of the N-terminal thrombospondin type 1 module and the membrane attack complex/perforin domain.
Molecular, genetic, and functional analysis of homozygous C8 beta-chain deficiency in two siblings.
Kirschfink et al., Ljubljana, Slovenia. In Immunopharmacology, 1997
Genetic analysis at the genomic DNA level demonstrated the common C-T mutation in exon 9 of the C8B gene.
The human complement C8G gene, a member of the lipocalin gene family: polymorphisms and mapping to chromosome 9q34.3.
Spurr et al., Bonn, Germany. In Ann Hum Genet, 1996
Complement component C8 is a plasma glycoprotein consisting of three nonidentical polypeptide chains (alpha, beta, gamma) which are encoded by three separate genes (C8A, C8B, C8G).
Detection of heterozygous C8 beta deficiency by PCR in a healthy Italian population.
Brai et al., Palermo, Italy. In Exp Clin Immunogenet, 1995
In this study we have screened a cohort of 527 Italian blood donors from western Sicily for the presence of C8B mutated allele.
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