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G protein-coupled receptor 77

C5L2, GPR77
The anaphylatoxins C3a (see MIM 120700), C4a (see MIM 120810), and C5a are cationic fragments generated during the complement cascade that participate in host defense. In the case of inappropriate complement activation, anaphylatoxins may be involved in autoimmunity and sepsis. C5L2 is coexpressed with the C5a receptor, C5AR (C5R1; MIM 113995), on polymorphonuclear neutrophils and may modulate C5AR activity (Gerard et al., 2005 [PubMed 16204243]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: C5a, ACID, V1a, CAN, HAD
Papers on C5L2
Complement 5a receptor-mediated neutrophil dysfunction is associated with a poor outcome in sepsis.
Wang et al., Beijing, China. In Cell Mol Immunol, Jan 2016
Complement 5a (C5a) has been implicated in the pathogenesis of sepsis by inducing the functional impairment of neutrophils; however, the utility of C5a receptors (C5aRs; C5aR and C5L2) as biomarkers for the management of sepsis is uncertain.
Atheroprotective role of C5ar2 deficiency in apolipoprotein E-deficient mice.
Shagdarsuren et al., Aachen, Germany. In Thromb Haemost, Oct 2015
Recently, we reported a clear correlation between high expressions of the second receptor for complement anaphylatoxin C5a, the C5a receptor-like 2 (C5L2, C5aR2), with high pro-inflammatory cytokine expression in advanced human atherosclerotic plaques.
Allosterism in human complement component 5a ((h)C5a): a damper of C5a receptor (C5aR) signaling.
Majhi et al., Bhubaneshwar, India. In J Biomol Struct Dyn, Sep 2015
One such example is the human C5a ((h)C5a), the potent cationic anaphylatoxin that engages C5aR and C5L2 to elicit numerous immunological and non-immunological responses in humans.
A New Approach for the Treatment of Arthritis in Mice with a Novel Conjugate of an Anti-C5aR1 Antibody and C5 Small Interfering RNA.
Banda et al., Aurora, United States. In J Immunol, Jul 2015
We first demonstrate that although C5aR2 or C5L2 (GPR77) plays no role in CAIA, C5aR1 contributes to pathogenesis.
Genetic polymorphisms in paraoxonase 1 and G protein-coupled receptor 77, and the risk of glucose-6-phosphate dehydrogenase deficiency in a Saudi population.
Alharbi, Riyadh, Saudi Arabia. In Saudi Med J, May 2015
Two common variants PON1 (rs662) and C5L2 (rs149572881) were genotyped using polymerase chain reaction followed by restriction fragment length polymorphism analysis.
Association of acylation-stimulating protein and receptor gene polymorphisms with coronary heart disease in Han and Hui populations.
Cao et al., Jinan, China. In Int J Clin Exp Med, 2014
OBJECTIVE: This study was to analyze the acylation-stimulating protein (ASP) (301T>C) and C5a-like receptor 2 (C5L2) (698C>T) gene polymorphisms in Han and Hui populations, and investigate their association with coronary heart disease (CHD).
Role of C5a-C5aR axis in the development of atherosclerosis.
Zhang et al., Jinan, China. In Sci China Life Sci, 2014
C5a and C5a desArg interact with their receptors (C5aR and C5L2), which results in a number of effects which are essential to the immune response.
Acute lung injury and the role of histones.
Grailer et al., Ann Arbor, United States. In Transl Respir Med, 2013
Extracellular histone appearance required both C5a receptors (C5aR, C5L2) as well as neutrophils (PMNs) and lung macrophages, as genetic loss of either C5a receptor or depletion of PMNs or macrophages reduced histone levels found in BALF during ALI.
Lung inflammation and damage induced by extracellular histones.
Ward et al., Ann Arbor, United States. In Inflamm Cell Signal, 2013
The presence of extracellular histones was dependent on the two C5a receptors (C5aR and C5L2) and availability of neutrophils.
C5L2: a controversial receptor of complement anaphylatoxin, C5a.
Woodruff et al., Australia. In Faseb J, 2013
In 2000, a second C5a receptor, C5L2 (previously known as GPR77), was discovered; yet, despite 12 yr of intensive research, its biological, or pathophysiological, function is both enigmatic and controversial.
Absence of signaling into CD4⁺ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3⁺ regulatory T cells.
Medof et al., Cleveland, United States. In Nat Immunol, 2013
Endogenous TGF-β1 suppressed signaling through C3aR and C5aR by preventing the production of C3a and C5a and upregulating C5L2, an alternative receptor for C5a.
International Union of Basic and Clinical Pharmacology. [corrected]. LXXXVII. Complement peptide C5a, C4a, and C3a receptors.
Monk et al., Hannover, Germany. In Pharmacol Rev, 2013
The most recently characterized receptor, the C5a₂ receptor (previously known as C5L2 or GPR77), has been regarded as a passive binding protein, but signaling activities are now ascribed to it, so we propose that it be formally identified as a receptor and be given a name to reflect this.
Structure, function and control of complement C5 and its proteolytic fragments.
Andersen et al., Århus, Denmark. In Curr Mol Med, 2012
The small anaphylatoxin C5a induces a variety of biological responses upon binding to the 7TM receptors C5aR and the C5L2, while the large C5b fragment nucleates formation of the membrane attack complex capable of killing susceptible pathogens by the formation of a pore structure in association with complement components C6, C7, C8, and C9.
Complement activation product C5a is a selective suppressor of TLR4-induced, but not TLR3-induced, production of IL-27(p28) from macrophages.
Ward et al., Ann Arbor, United States. In J Immunol, 2012
C5a suppresses IL-27(p28) in lipopolysaccharide-stimulated peritoneal macrophages via interactions with the C5aR receptor rather than the C5L2 receptor.
Genetic analysis of C5a receptors in neutrophils from patients with familial Mediterranean fever.
Mitroulis et al., Alexandroúpolis, Greece. In Mol Biol Rep, 2012
The aim of this study was to investigate the genetic alterations and mRNA expression pattern of C5aR and C5L2 genes in neutrophils from attack-free familial Mediterranean fever patients.
Relationship between type 2 diabetes mellitus and a novel polymorphism C698T in C5L2 in the Chinese Han population.
Liu et al., Ürümqi, China. In Endocrine, 2012
genetic association studies in the Chinese Han population: Data suggest that an SNP in C5L2 (C698T) is associated with type 2 diabetes mellitus; 698CT heterozygotes exhibited increased serum triglyceride levels.
Relationship between a novel polymorphism of the C5L2 gene and coronary artery disease.
Liu et al., Ürümqi, China. In Plos One, 2010
698CT genotype of C5L2 may be a genetic maker of CAD in the Han and Uygur population in western China
S323I polymorphism of the C5L2 gene was not identified in a Chinese population with familial combined hyperlipidemia or with type 2 diabetes.
Chen et al., Ürümqi, China. In Genet Mol Res, 2010
Neither the familial combined hyperlipidemia subjects nor the type 2 diabetes patients were found to have the S323I variant of the C5L2 gene.
Functional roles for C5a receptors in sepsis.
Ward et al., Ann Arbor, United States. In Nat Med, 2008
C5l2 is required for the release of HMGB1, is a functional receptor and contributes synergistically with C5ar to the harmful consequences in sepsis.
C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a.
Yeh et al., Toronto, Canada. In Nature, 2007
data indicate that C5L2 can function as a positive modulator for both C5a- and C3a-anaphylatoxin-induced responses
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