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CDK5 regulatory subunit associated protein 3

C53, RPC53, BN51
Neuronal CDC2-like kinase, which is involved in the regulation of neuronal differentiation, is composed of a catalytic subunit, CDK5, and an activating subunit, p25NCK5A. The protein encoded by this gene binds to p25NCK5A and therefore may be involved in neuronal differentiation. The encoded protein, which may be a substrate of neuronal CDC2-like kinase, has also been found in vascular endothelial cells, where it mediates cell proliferation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: POLYMERASE, ACID, Mcl-1, MAX, Chx10
Papers on C53
SAD1, an RNA polymerase I subunit A34.5 of rice, interacts with Mediator and controls various aspects of plant development.
Kyozuka et al., Tokyo, Japan. In Plant J, 2015
TFIIF2 and RPC53 are the counterparts of RPA34.5 in Pol II and Pol III, respectively.
Release of targeted p53 from the mitochondrion as an early signal during mitochondrial dysfunction.
Knudsen et al., Louisville, United States. In Cell Signal, 2013
To investigate the fate of mitochondrial-sequestered p53, mouse embryonic fibroblast cells (MEFs) on a p53-deficient genetic background were transfected with p53-EGFP fusion protein led by a sense (m53-EGFP) or antisense (c53-EGFP) mitochondrial import signal.
Nuclear γ-tubulin associates with nucleoli and interacts with tumor suppressor protein C53.
Dráber et al., Czech Republic. In J Cell Physiol, 2012
Nuclear gamma-tubulin interacts with tumor suppressor protein C53 that is involved in regulation of DNA damage
Interaction of LHBs with C53 promotes hepatocyte mitotic entry: A novel mechanism for HBV-induced hepatocellular carcinoma.
Zhang et al., Beijing, China. In Oncol Rep, 2012
our results strongly suggest that the binding of hepatitis viral pre-S2 LHBs with C53 is a novel negative regulator of the checkpoint response
Overexpression of a novel activator of PAK4, the CDK5 kinase-associated protein CDK5RAP3, promotes hepatocellular carcinoma metastasis.
Ching et al., Hong Kong, Hong Kong. In Cancer Res, 2011
Findings reveal that CDK5RAP3 is widely overexpressed in hepatocellular carcinoma and that overexpression of CDK5RAP3 promotes HCC metastasis through PAK4 activation.
A functional variant of IC53 correlates with the late onset of colorectal cancer.
Hui et al., Beijing, China. In Mol Med, 2010
Data indicate that IC53 is a positive mediator for colon cancer progression, and IC53-rs2737 may serve as protection from the onset of colorectal cancer.
Identification of LZAP as a new candidate tumor suppressor in hepatocellular carcinoma.
Xia et al., Guangzhou, China. In Plos One, 2010
LZAP may play an important role in hepatocellular carcinoma progression
Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits.
Hernandez et al., Stony Brook, United States. In Mol Cell Biol, 2002
RPC5 associated with RPC53, the human orthologue of S. cerevisiae C53, paralleling the association of the S. cerevisiae C37 and C53 subunits, and was required for transcription from the type 2 VAI and type 3 human U6 promoters.
[Study on expression of cell cycle-related genes in subclonal cell lines of human cervical carcinoma].
Cheng et al., Xi'an, China. In Zhonghua Fu Chan Ke Za Zhi, 2002
By applying this cDNA microarray, we identified 3 differentially expressed genes in two homologous cell lines, which were BN51, hsp90 and Mcl-1 genes, further identified 3 upregulated genes in CS07 cell line, the ratio of Cy5/Cy3 was 0.480, 0.479 and 0.490 respectively.
Identification of a region of RyR1 that participates in allosteric coupling with the alpha(1S) (Ca(V)1.1) II-III loop.
Beam et al., Fort Collins, United States. In J Biol Chem, 2002
No interaction was observed for sR16 x c53 (alpha(1C) 850-897), but weak interaction was occasionally observed for s53 x cR16 (RyR2 1817-2142).
Myc induces the nucleolin and BN51 genes: possible implications in ribosome biogenesis.
Amati et al., China. In Nucleic Acids Res, 2000
These encode nucleolin, an abundant nucleolar protein, and BN51, a co-factor of RNA polymerase III.
Analysis of a 23 kb region on the left arm of yeast chromosome IV.
Perea et al., Paris, France. In Yeast, 1996
This sequence contains the 3' coding region of the STE7 and RET1 (COP1) genes, and 13 complete open reading frames longer than 300 bp, of which ten correspond to putative new genes and three (CLB3, MSH5 and RPC53) have been sequenced previously.
The BN51 protein is a polymerase (Pol)-specific subunit of RNA Pol III which reveals a link between Pol III transcription and pre-rRNA processing.
Pugh et al., University Park, United States. In Mol Cell Biol, 1995
The human BN51 gene was originally isolated as a suppressor of a temperature-sensitive cell cycle mutant of BHK cells (tsBN51).
Cell cycle control of the BN51 cell cycle gene which encodes a subunit of RNA polymerase III.
Ittmann, New York City, United States. In Cell Growth Differ, 1994
The BN51 cell cycle gene complements a temperature-sensitive cell cycle mutation of BHK-21 cells which leads to arrest in G1 at the nonpermissive temperature.
The gene complementing a temperature-sensitive cell cycle mutant of BHK cells is the human homologue of the yeast RPC53 gene, which encodes a subunit of RNA polymerase C (III).
Basilico et al., New York City, United States. In Cell Growth Differ, 1993
The temperature-sensitive BN51 cell cycle mutant of BHK cells arrests in G1 at the nonpermissive temperature (39.5 degrees C).
A general suppressor of RNA polymerase I, II and III mutations in Saccharomyces cerevisiae.
Thuriaux et al., Gif-sur-Yvette, France. In Mol Gen Genet, 1993
A multicopy genomic library of Saccharomyces cerevisiae (strain FL100) was screened for its ability to suppress conditionally defective mutations altering the 31 kDa subunit (rpc31-236) or the 53 kDa subunit (rpc53-254/424) of RNA polymerase III.
Biochemical and genetic dissection of the Saccharomyces cerevisiae RNA polymerase C53 subunit through the analysis of a mitochondrially mis-sorted mutant construct.
Mann et al., Gif-sur-Yvette, France. In J Biol Chem, 1992
In this paper, we have determined that an unusual rho+ lethality associated with the rpc53::HIS3-1 disruption mutation is due to the inadvertent formation of a Pet56-C53 fusion protein.
RPC53 encodes a subunit of Saccharomyces cerevisiae RNA polymerase C (III) whose inactivation leads to a predominantly G1 arrest.
Sentenac et al., Gif-sur-Yvette, France. In Mol Cell Biol, 1992
RPC53 is shown to be an essential gene encoding the C53 subunit specifically associated with yeast RNA polymerase C (III).
Isolation of the human gene that complements a temperature-sensitive cell cycle mutation in BHK cells.
Basilico et al., New York City, United States. In Mol Cell Biol, 1987
We have cloned the human genomic DNA and the corresponding cDNA for the gene which complements the mutation of tsBN51, a temperature-sensitive (Ts) cell cycle mutant of BHK cells which is blocked in G1 at the nonpermissive temperature.
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