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CDK5 regulatory subunit associated protein 2

Neuronal CDC2-like kinase, which is involved in the regulation of neuronal differentiation, is composed of a catalytic subunit, CDK5, and an activating subunit, p25NCK5A. The protein encoded by this gene binds to p25NCK5A and therefore may be involved in neuronal differentiation. The encoded protein may also be a substrate of neuronal CDC2-like kinase. Multiple transcript variants exist for this gene, but the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ASPM, MCPH1, LAP, MAST, CAN
Papers on C48
Phosphorylation of the centrosomal protein, Cep169, by Cdk1 promotes its dissociation from centrosomes in mitosis.
Terada et al., Tokyo, Japan. In Biochem Biophys Res Commun, Jan 2016
Here we show that Cep169 associates with centrosomes during interphase, but dissociates from these structures from the onset of mitosis, although CDK5RAP2 (Cep215) is continuously located at the centrosomes throughout cell cycle.
Microtubule-bundling activity of the centrosomal protein, Cep169, and its binding to microtubules.
Terada et al., Tokyo, Japan. In Biochem Biophys Res Commun, Dec 2015
CDK5RAP2 is a centrosomal protein that regulates the recruitment of a γ-tubulin ring complex (γ-TuRC) onto centrosomes and microtubules (MTs) dynamics as a member of MT plus-end-tracking proteins (+TIPs).
Loss of γ-tubulin, GCP-WD/NEDD1 and CDK5RAP2 from the Centrosome of Neurons in Developing Mouse Cerebral and Cerebellar Cortex.
Hayashi et al., Tokyo, Japan. In Acta Histochem Cytochem, Nov 2015
Microtubule nucleation requires γ-tubulin as well as its recruiting proteins, GCP-WD/NEDD1 and CDK5RAP2 that anchor γ-tubulin to the centrosome.
PLK1-dependent activation of LRRK1 regulates spindle orientation by phosphorylating CDK5RAP2.
Matsumoto et al., Nagoya, Japan. In Nat Cell Biol, Aug 2015
Interestingly, LRRK1 in turn phosphorylates CDK5RAP2(Cep215), a human homologue of Drosophila Centrosomin (Cnn), in its γ-tubulin-binding motif, thus promoting the interaction of CDK5RAP2 with γ-tubulin.
Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing.
Pagano et al., New York City, United States. In Nat Cell Biol, 2015
We also found that Cep68 forms a complex with Cep215 (also known as Cdk5Rap2) and PCNT (also known as pericentrin), two PCM (pericentriolar material) proteins involved in centriole engagement.
Cep169, a Novel Microtubule Plus-End-Tracking Centrosomal Protein, Binds to CDK5RAP2 and Regulates Microtubule Stability.
Terada et al., Tokyo, Japan. In Plos One, 2014
The centrosomal protein, CDK5RAP2, is a microcephaly protein that regulates centrosomal maturation by recruitment of a γ-tubulin ring complex (γ-TuRC) onto centrosomes.
Molecular genetics of human primary microcephaly: an overview.
Saleh Jamal et al., In Bmc Med Genomics, 2014
Twelve MCPH loci (MCPH1-MCPH12) have been mapped to date from various populations around the world and contain the following genes: Microcephalin, WDR62, CDK5RAP2, CASC5, ASPM, CENPJ, STIL, CEP135, CEP152, ZNF335, PHC1 and CDK6.
Species-Specific Expression of Full-Length and Alternatively Spliced Variant Forms of CDK5RAP2.
Lee et al., Calgary, Canada. In Plos One, 2014
CDK5RAP2 is one of the primary microcephaly genes that are associated with reduced brain size and mental retardation.
Subdiffraction imaging of centrosomes reveals higher-order organizational features of pericentriolar material.
Pelletier et al., Toronto, Canada. In Nat Cell Biol, 2012
We find that PCM components occupy separable spatial domains within mitotic PCM that are maintained in the absence of microtubule nucleation complexes and further implicate PCNT and CDK5RAP2 in the organization and assembly of PCM.
Activation of Aurora-A is essential for neuronal migration via modulation of microtubule organization.
Hirotsune et al., Ōsaka, Japan. In J Neurosci, 2012
This study demonistrated that CDK5RAP2 is a key molecule that mediates functional interaction and is essential for centrosomal targeting of Aurora-A.
Pattern formation in centrosome assembly.
Venkitaraman et al., Cambridge, United Kingdom. In Curr Opin Cell Biol, 2012
Here we use recent insights into the spatio-temporal behaviour of key regulators of centrosomal maturation, including Polo-like kinase 1, CDK5RAP2 and Aurora-A, to propose a model for the assembly and maintenance of the PCM through the mobility and local interactions of its constituent proteins.
Microcephaly genes and risk of late-onset Alzheimer disease.
Kaye et al., Portland, United States. In Alzheimer Dis Assoc Disord, 2011
We conclude that the common variations we measured in the 4 microcephaly genes, ASPM, MCPH1, CDK5RAP2, and CENPJ, do not affect the risk of Alzheimer disease
What's the hype about CDK5RAP2?
Kaindl et al., Berlin, Germany. In Cell Mol Life Sci, 2011
Cyclin dependent kinase 5 regulatory subunit-associated protein 2 (CDK5RAP2) has gained attention in the last years following the discovery, in 2005, that recessive mutations cause primary autosomal recessive microcephaly.
Primary microcephaly 3 (MCPH3): revisiting two critical mutations.
Lee et al., In Cell Cycle, 2011
The deletion of the C-terminal structural maintenance of chromosome (SMC) domain and the p35-binding domain in both patient pedigrees 1 and 2 CDK5RAP2 is sufficient for the development of MCPH3-associated primary microcephaly.
Novel alternatively spliced variant form of human CDK5RAP2.
Lee et al., In Cell Cycle, 2011
A report of an novel alternatively spliced variant form of hCDK5RAP2, hCDK5RAP2 variant 1 (hCDK5RAP2-V1) which lacks the 237 nucleotide residues of hCDK5RAP2 exon 32.
Autosomal Recessive Primary Microcephaly (MCPH): clinical manifestations, genetic heterogeneity and mutation continuum.
Hassan et al., Lahore, Pakistan. In Orphanet J Rare Dis, 2010
So far, seven genetic loci (MCPH1-7) for this condition have been mapped with seven corresponding genes (MCPH1, WDR62, CDK5RAP2, CEP152, ASPM, CENPJ, and STIL) identified from different world populations.
CDK5RAP2 regulates centriole engagement and cohesion in mice.
Megraw et al., Dallas, United States. In Dev Cell, 2010
These results indicate that CDK5RAP2 is required to maintain centriole engagement and cohesion, thereby restricting centriole replication.
Primary Autosomal Recessive Microcephalies and Seckel Syndrome Spectrum Disorders
Passemard et al., Seattle, United States. In Unknown Journal, 2009
The genes in which biallelic mutation is known to cause MCPH-SCKS spectrum disorders are separated into those that are currently known to be associated with: MCPH phenotype only: MCPH1 (locus name MCPH1), WDR62 (MCPH2), CDK5RAP2 (MCPH3), CASC5 (MCPH4), ASPM (MCPH5), STIL (MCPH7), CEP135 (MCPH8), and CDK6 (MCPH12); SCKS phenotype only: ATR (locus name SCKL1), NIN (SCKL7), and ATRIP ; and MCPH, SCKS, and/or intermediate phenotypes: RBBP8 (locus name SCKL2), CEP152 (MCPH9/SCKL5), CENPJ (MCPH6/SCKL4), CEP63 (SCKL6), and PHC1 (MCPH11).
Mutations in the pericentrin (PCNT) gene cause primordial dwarfism.
Reis et al., Erlangen, Germany. In Science, 2008
Mutations in related genes are known to cause primary microcephaly (MCPH1, CDK5RAP2, ASPM, and CENPJ).
A centrosomal mechanism involving CDK5RAP2 and CENPJ controls brain size.
Woods et al., Leeds, United Kingdom. In Nat Genet, 2005
Mutations in CDK5RAP2 gene is associated with autosomal recessive primary microcephaly
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