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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Chromosome 20 open reading frame 20

C20orf20, MRGBP, MRG binding protein
Top mentioned proteins: Histone, MRG15, BLBP, V1a, CAN
Papers on C20orf20
Structural Basis for Multi-specificity of MRG Domains.
Radhakrishnan et al., Evanston, United States. In Structure, Jul 2015
We now show that MRGBP, a member of the Tip60/NuA4 histone acetyltransferase complex, engages the same two surfaces of the MRG domain as Pf1.
A genetic screen in Drosophila for regulators of human prostate cancer progression.
Miki et al., Kyoto, Japan. In Biochem Biophys Res Commun, 2014
The human homologues of these candidate genes - MRGBP, CNPY2, and MEP1A - were found to be expressed in human prostate cancer model cells and to promote replication and invasiveness in these cells.
Characterization of native protein complexes and protein isoform variation using size-fractionation-based quantitative proteomics.
Lamond et al., Dundee, United Kingdom. In Mol Cell Proteomics, 2013
Specific proteins were detected interacting with multiple independent complexes, as typified by the separation of distinct complexes for the MRFAP1-MORF4L1-MRGBP interaction network.
Characterization of MRFAP1 turnover and interactions downstream of the NEDD8 pathway.
Lamond et al., Dundee, United Kingdom. In Mol Cell Proteomics, 2012
MRFAP1 bound to a number of E3 ubiquitin ligases, including CUL4B, but not to components of the NuA4 complex, including MRGBP, which bound to MORF4L1.
Integrative mRNA profiling comparing cultured primary cells with clinical samples reveals PLK1 and C20orf20 as therapeutic targets in cutaneous squamous cell carcinoma.
South et al., Dundee, United Kingdom. In Oncogene, 2011
role in tumorogenesis of cutaneous squamous cell carcinoma
MRG-binding protein contributes to colorectal cancer development.
Furukawa et al., Tokyo, Japan. In Cancer Sci, 2011
MRGBP contributes to colorectal carcinogenesis through rendering advantages in cell proliferation and/or division of cancer cells.
C20orf20 (MRG-binding protein) as a potential therapeutic target for colorectal cancer.
Furukawa et al., Tokyo, Japan. In Br J Cancer, 2010
These results suggest that C20orf20 protein has an important function in proliferation of cancer cells through the regulation of BRD8 protein.
Multiple putative oncogenes at the chromosome 20q amplicon contribute to colorectal adenoma to carcinoma progression.
Meijer et al., Amsterdam, Netherlands. In Gut, 2009
RESULTS: The genes C20orf24, AURKA, RNPC1, TH1L, ADRM1, C20orf20 and TCFL5, mapping at 20q, were significantly overexpressed in carcinomas compared with adenomas as a consequence of copy number gain of 20q.
Identification of copy number gain and overexpressed genes on chromosome arm 20q by an integrative genomic approach in cervical cancer: potential role in progression.
Murty et al., New York City, United States. In Genes Chromosomes Cancer, 2008
These include a number of functionally important genes in cell cycle regulation (E2F1, TPX2, KIF3B, PIGT, and B4GALT5), nuclear function (CSEL1), viral replication (PSMA7 and LAMA5), methylation and chromatin remodeling (ASXL1, AHCY, and C20orf20), and transcription regulation (TCEA2).
Multipurpose MRG domain involved in cell senescence and proliferation exhibits structural homology to a DNA-interacting domain.
Quiocho et al., Houston, United States. In Structure, 2006
These proteins are defined by the approximately 20 kDa MRG domain that binds a plethora of transcriptional regulators and chromatin-remodeling factors, including the histone deacetylase transcriptional corepressor mSin3A and the novel nuclear protein PAM14, and they are also known components of the Tip60/NuA4 complex via interactions with the MRG binding protein (MRGBP).
Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex.
Conaway et al., Kansas City, United States. In J Biol Chem, 2003
MRGBP is encoded by the FLJ10914 ORF and is a new component of the TRRAP/TIP60 HAT complex
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