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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

V-yes-1 Yamaguchi sarcoma viral oncogene homolog 1

c-Yes, YES1
This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Src, alpha-Synuclein, CAN, V1a, Lyn
Papers on c-Yes
Up-regulation of microRNA-210 inhibits proliferation of hepatocellular carcinoma cells by targeting YES1.
Tan et al., Singapore, Singapore. In World J Gastroenterol, Jan 2016
Luciferase reporter constructs were used to identify the miR-210 interacting site on Yes1.
Bioluminescence Methods for Assaying Kinases in Quantitative High-Throughput Screening (qHTS) Format Applied to Yes1 Tyrosine Kinase, Glucokinase, and PI5P4Kα Lipid Kinase.
Inglese et al., Rockville, United States. In Methods Mol Biol, Dec 2015
Assays in which the detection of a biological phenomenon is coupled to the production of bioluminescence by luciferase have gained widespread use.
Fyn Accelerates M Phase Progression by Promoting the Assembly of Mitotic Spindle Microtubules.
Yamaguchi et al., Chiba, Japan. In J Cell Biochem, Oct 2015
Re-expression of Fyn induced increases in the fluorescence intensity of mitotic spindle microtubules in SYF cells having triple knock-out mutations of c-Src, c-Yes, and Fyn.
Hippo pathway elements Co-localize with Occludin: A possible sensor system in pancreatic epithelial cells.
Mrsny et al., İstanbul, Turkey. In Tissue Barriers, Jul 2015
Occludin (Ocln), a tetraspanning protein associated with TJ structures and capable of establishing external cell-cell contacts, was observed to partially co-localize with Hpo elements YAP (c-yes associated protein) and TEAD (TEA-dependent), which function to drive a proliferative transcription program.
MiR-17-5p up-regulates YES1 to modulate the cell cycle progression and apoptosis in ovarian cancer cell lines.
Tang et al., Tianjin, China. In J Cell Biochem, Jun 2015
YES1 was identified as a novel target gene of miR-17-5p.
Use of mechanistic models to integrate and analyze multiple proteomic datasets.
Hlavacek et al., Mexico. In Biophys J, May 2015
Proteins with high importance rank in multiple cell lines include proteins with recognized, well-characterized roles in EGFR signaling, such as GRB2 and SHC1, as well as a protein with a less well-defined role, YES1.
Identification of miR-145 targets through an integrated omics analysis.
Pandey et al., Baltimore, United States. In Mol Biosyst, 2015
In our transcriptomic analysis, overexpression of miR-145 was found to suppress the expression of genes that are implicated in development of cancer such as ITGA11 and MAGEA4 in addition to previously described targets such as FSCN1, YES1 and PODXL.
Runs of homozygosity reveal signatures of positive selection for reproduction traits in breed and non-breed horses.
Distl et al., Hannover, Germany. In Bmc Genomics, 2014
In non-breed horses, 198 ROHs in 50-SNP windows and seven ROHs in 500-SNP windows showed an enrichment of genes involved in reproduction, embryonic development, energy metabolism, muscle and cardiac development whereas all seven breed horses revealed only three common ROHs in 50-SNP windows harboring the fertility-related gene YES1.
Src-family tyrosine kinase activities are essential for differentiation of human embryonic stem cells.
Smithgall et al., Pittsburgh, United States. In Stem Cell Res, 2014
Both Hck and c-Yes are important in self-renewal, while c-Src activity alone is sufficient to induce differentiation.
Germ cell transport across the seminiferous epithelium during spermatogenesis.
Cheng et al., Hong Kong, Hong Kong. In Physiology (bethesda), 2014
Signaling molecules, such as focal adhesion kinase, c-Yes, c-Src, and intercellular adhesion molecules 1 and 2, are involved in these events by regulating actin-based cytoskeleton via their action on actin-regulating proteins, endocytic vesicle-mediated protein trafficking, and adhesion protein complexes.
Role of non-receptor protein tyrosine kinases in spermatid transport during spermatogenesis.
Cheng et al., New York City, United States. In Semin Cell Dev Biol, 2014
Herein, we focus on the role of non-receptor protein tyrosine kinases, most notably, FAK, c-Yes and c-Src, in the transport of spermatids across the seminiferous epithelium during spermatogenesis.
β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis.
Hahn et al., Boston, United States. In Cell, 2013
Phosphorylation of YAP1 by the tyrosine kinase YES1 leads to localization of this complex to the promoters of antiapoptotic genes, including BCL2L1 and BIRC5.
LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma.
Sharpless et al., Chapel Hill, United States. In Cancer Cell, 2012
Results suggest that LKB1 inactivation in the context of RAS activation facilitates metastasis by inducing an SFK-dependent expansion of a prometastatic, CD24(+) tumor subpopulation.
The blood-testis barrier and its implications for male contraception.
Mruk et al., New York City, United States. In Pharmacol Rev, 2012
Studies have demonstrated that some unlikely partners, namely adhesion protein complexes (e.g., occludin-ZO-1, N-cadherin-β-catenin, claudin-5-ZO-1), steroids (e.g., testosterone, estradiol-17β), nonreceptor protein kinases (e.g., focal adhesion kinase, c-Src, c-Yes), polarity proteins (e.g., PAR6, Cdc42, 14-3-3), endocytic vesicle proteins (e.g., clathrin, caveolin, dynamin 2), and actin regulatory proteins (e.g., Eps8, Arp2/3 complex), are working together, apparently under the overall influence of cytokines (e.g., transforming growth factor-β3, tumor necrosis factor-α, interleukin-1α).
Functional activation of Src family kinase yes protein is essential for the enhanced malignant properties of human melanoma cells expressing ganglioside GD3.
Furukawa et al., United States. In J Biol Chem, 2011
Functional activation of Src family kinase yes protein is essential for the enhanced malignant properties of human melanoma cells expressing ganglioside GD3.
Regulation of mouse embryonic stem cell self-renewal by a Yes-YAP-TEAD2 signaling pathway downstream of LIF.
Annerén et al., Uppsala, Sweden. In J Cell Sci, 2011
YAP, TEAD2 and Yes are highly expressed in self-renewing embryonic stem cells, and are activated by LIF.
c-Yes regulates cell adhesion at the blood-testis barrier and the apical ectoplasmic specialization in the seminiferous epithelium of rat testes.
Cheng et al., New York City, United States. In Int J Biochem Cell Biol, 2011
c-Yes regulates blood-testis barrier and apical ectoplasmic specialization integrity by maintaining proper distribution of integral membrane proteins and actin filament organization at these sites
Specific oncogenic activity of the Src-family tyrosine kinase c-Yes in colon carcinoma cells.
Cruzalegui et al., Vitry-sur-Seine, France. In Plos One, 2010
c-Yes regulates specific oncogenic signalling pathways important for colon cancer progression that is not shared with c-Src.
c-Yes response to growth factor activation.
Flynn et al., Morgantown, United States. In Growth Factors, 2005
The most studied kinase of this nine member family, c-Src, shares a similar structure, as well as a similar expression pattern to that of another Src family protein, c-Yes.
Specificity in signaling by c-Yes.
Flynn et al., Morgantown, United States. In Front Biosci, 2003
This review summarizes the potential functions of c-Yes and its ability to modulate signals that are distinct from c-Src.
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