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C-type lectin domain family 1, member A

C-type lectin-like receptor, CLEC-1, a C-type lectin-like receptor, C-type lectin-like receptor gene
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded protein may play a role in regulating dendritic cell function. Alternative splice variants have been described but their biological nature has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CLEC-2, CAN, CD45, Dectin-1, Syk
Papers on C-type lectin-like receptor
Establishment of Novel Monoclonal Antibody PMab-32 Against Rabbit Podoplanin.
Kato et al., Sendai, Japan. In Monoclon Antib Immunodiagn Immunother, Feb 2016
PDPN activates platelet aggregation by binding to C-type lectin-like receptor-2 (CLEC-2) on platelet.
Platelets Regulate the Migration of Keratinocytes via Podoplanin/CLEC-2 Signaling during Cutaneous Wound Healing in Mice.
Katoh et al., Kyoto, Japan. In Am J Pathol, Jan 2016
Podoplanin is an endogenous ligand for C-type lectin-like receptor 2 (CLEC-2), which is expressed on platelets.
Identification of a novel platelet antagonist that binds to CLEC-2 and suppresses podoplanin-induced platelet aggregation and cancer metastasis.
Tseng et al., Anyang, China. In Oncotarget, Jan 2016
Podoplanin (PDPN) enhances tumor metastases by eliciting tumor cell-induced platelet aggregation (TCIPA) through activation of platelet C-type lectin-like receptor 2 (CLEC-2).
Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets.
Cunningham et al., In J Clin Invest, Jan 2016
Here, using a mouse model of systemic Salmonella Typhimurium infection, we determined that inflammation in tissues triggers thrombosis within vessels via ligation of C-type lectin-like receptor-2 (CLEC-2) on platelets by podoplanin exposed to the vasculature following breaching of the vessel wall.
Development of Sensitive Monoclonal Antibody PMab-2 Against Rat Podoplanin.
Kato et al., Sendai, Japan. In Monoclon Antib Immunodiagn Immunother, Dec 2015
Podoplanin (PDPN) is a platelet aggregation-inducing factor, which is known as an endogenous ligand of C-type lectin-like receptor-2 (CLEC-2).
CLEC-2 in megakaryocytes is critical for maintenance of hematopoietic stem cells in the bone marrow.
Suda et al., Tokyo, Japan. In J Exp Med, Dec 2015
Here, we demonstrate that the membrane protein C-type lectin-like receptor-2 (CLEC-2) mediates the production of Thpo and other factors in Mks.
Development of Monoclonal Antibody LpMab-10 Recognizing Non-glycosylated PLAG1/2 Domain Including Thr34 of Human Podoplanin.
Kato et al., Sendai, Japan. In Monoclon Antib Immunodiagn Immunother, Oct 2015
Among the three PLAG domains, O-glycan on Thr52 of PLAG3 is critical for binding with C-type lectin-like receptor-2 (CLEC-2) and is essential for platelet-aggregating activity of PDPN.
Targeting platelet receptors in thrombotic and thrombo-inflammatory disorders.
Nieswandt et al., Würzburg, Germany. In Hamostaseologie, 2014
This review summarizes recent developments in understanding the function of glycoprotein (GP)Ib, GPVI and the C-type lectin-like receptor 2 (CLEC-2) in hemostasis, arterial thrombosis and thrombo-inflammation and will discuss the suitability of the receptors as novel targets to treat these diseases in humans.
Molecular Characterization and Biological Effects of a C-Type Lectin-Like Receptor in Large Yellow Croaker (Larimichthys crocea).
Chen et al., Xiamen, China. In Int J Mol Sci, 2014
Here, we cloned and characterized a C-type lectin-like receptor (LycCTLR) from large yellow croaker Larimichthys crocea.
C-type lectin-like receptor LOX-1 promotes dendritic cell-mediated class-switched B cell responses.
Oh et al., Dallas, United States. In Immunity, 2014
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a pattern-recognition receptor for a variety of endogenous and exogenous ligands.
Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2.
Xia et al., Oklahoma City, United States. In Nature, 2013
Further analyses demonstrated that PDPN expressed on fibroblastic reticular cells, which surround HEVs, functions as an activating ligand for platelet C-type lectin-like receptor 2 (CLEC-2, also known as CLEC1B).
Platelet ITAM signaling.
Stefanini et al., Chapel Hill, United States. In Curr Opin Hematol, 2013
In contrast, deficiency in the immunoreceptor tyrosine-based activation motif (ITAM)-coupled receptors glycoprotein (GP)VI or C-type lectin-like receptor (CLEC)-2 is associated with only a mild bleeding diathesis in humans and mice.
The Dectin-2 family of C-type lectin-like receptors: an update.
Brown et al., Aberdeen, United Kingdom. In Int Immunol, 2013
Myeloid and non-myeloid cells express members of the C-type lectin-like receptor (CTLR) family, which mediate crucial cellular functions during immunity and homeostasis.
[A role of the platelet receptor CLEC-2 in lymphangiogenesis and its clinical application].
Ozaki et al., Japan. In Rinsho Byori, 2013
We discovered that a platelet receptor, C-type lectin-like receptor 2 (CLEC-2), facilitates lymph/blood vessel separation in the developmental stage by binding to its ligand, podoplanin, on lymphatic endothelial cells.
Modulation of NK cell function by genetically coupled C-type lectin-like receptor/ligand pairs encoded in the human natural killer gene complex.
Steinle et al., Frankfurt am Main, Germany. In Front Immunol, 2012
Functional responses of natural killer (NK) cells including eradication of "harmful" cells and modulation of immune responses are regulated by a broad variety of activating and inhibitory NK receptors.
The human C-type lectin-like receptor CLEC-1 is upregulated by TGF-β and primarily localized in the endoplasmic membrane compartment.
Hofer et al., Vienna, Austria. In Scand J Immunol, 2012
Expression of CLEC-1 mRNA was detected in myeloid cells as well as in endothelial cells. CLEC-1 protein displayed N-linked glycosylation and formed dimers.
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