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bystin, Enp1, BYSL
Bystin is expressed as a 2-kb major transcript and a 3.6-kb minor transcript in SNG-M cells and in human trophoblastic teratocarcinoma HT-H cells. Protein binding assays determined that bystin binds directly to trophinin and tastin, and that binding is enhanced when cytokeratins 8 and 18 are present. Immunocytochemistry of HT-H cells showed that bystin colocalizes with trophinin, tastin, and the cytokeratins, suggesting that these molecules form a complex in trophectoderm cells at the time of implantation. Using immunohistochemistry it was determined that trophinin and bystin are found in the placenta from the sixth week of pregnancy. Both proteins were localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. After week 10, the levels of trophinin, tastin, and bystin decreased and then disappeared from placental villi. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, fibrillin-1, Glial Fibrillary Acidic Protein
Papers on bystin
CK1δ and CK1ε are components of human 40S subunit precursors required for cytoplasmic 40S maturation.
Kutay et al., Zürich, Switzerland. In J Cell Sci, 2014
We show that both CK1δ and CK1ε isoforms are components of pre-40S subunits, on which they phosphorylate the ribosome biogenesis factors ENP1/BYSL and LTV1.
Developmentally restricted differentiation antigens are targets for immunotherapy in epithelial ovarian carcinoma.
Odunsi et al., Buffalo, United States. In Int J Gynecol Pathol, 2013
Developmentally restricted differentiation antigens or cancer-placental antigens, tastin and bystin, are components of an adhesion molecule that plays a critical role in the implantation of the embryo to the uterus.
Identification of the causative gene for Simmental arachnomelia syndrome using a network-based disease gene prioritization approach.
Zhang et al., Beijing, China. In Plos One, 2012
Two suspicious mutations located in coding regions, a mis-sense mutation c.1303G>A in the bystin-like (BYSL) gene and a 2-bp deletion mutation c.1224_1225delCA in the molybdenum cofactor synthesis step 1 (MOCS1) gene were detected.
Cell adhesion molecules in human embryo implantation.
Sugihara et al., Los Angeles, United States. In Sheng Li Xue Bao, 2012
Here, we describe the dual roles of mucin carbohydrate ligand for L-selectin and trophinin protein and of the trophinin-associated proteins bystin and tastin.
A modified in vitro method to obtain pure astrocyte cultures induced from mouse hippocampal neural stem cells using clonal expansion.
Li et al., Shanghai, China. In Cell Mol Neurobiol, 2012
Induced cells resembled primary astrocyte cultures in functional properties such as cell proliferation rates and lack of tumorigenicity and p53, and expression of epidermal growth factor receptor, bystin, and nitric oxygen synthase.
Activating transcription factor 3 and reactive astrocytes following optic nerve injury in zebrafish.
García et al., San Marcos, United States. In Comp Biochem Physiol C Toxicol Pharmacol, 2012
Here we use a polyclonal anti-ATF3 antibody, anti-cytokeratin (KRT-18) and anti-bystin (BYSL) antibodies to show that Atf3 and Bysl colocalize with cytokeratin-expressing astrocytes in the optic nerve following severing.
Trophinin in cell adhesion and signal transduction.
Sugihara et al., Los Angeles, United States. In Front Biosci (elite Ed), 2011
Here, we describe characteristics of trophinin protein and of the trophinin-associated proteins bystin and tastin.
Enhancement of mouse sperm motility by trophinin-binding peptide.
Fukuda et al., Los Angeles, United States. In Reprod Biol Endocrinol, 2011
BACKGROUND: Trophinin is an intrinsic membrane protein that forms a complex in the cytoplasm with bystin and tastin, linking it microtubule-associated motor dynein (ATPase) in some cell types.
Structural characterization of extracellular polysaccharides produced by the marine fungus Epicoccum nigrum JJY-40 and their antioxidant activities.
Yang et al., Qingdao, China. In Mar Biotechnol (ny), 2011
Two extracellular polysaccharides, ENP1 and ENP2, were isolated from the fermentation liquid of the marine fungus Epicoccum nigrum JJY-40 by anion-exchange chromatography and gel-filtration chromatography, and their structures were investigated using chemical and spectroscopic methods including methylation analysis and NMR spectroscopy.
Analysis of two human pre-ribosomal factors, bystin and hTsr1, highlights differences in evolution of ribosome biogenesis between yeast and mammals.
Gleizes et al., Toulouse, France. In Nucleic Acids Res, 2011
bystin is necessary for efficient cleavage of the internal transcribed spacer 1 at site 2 and for further processing of the pre-rRNA.
Hyperthermic preconditioning protects astrocytes from ischemia/reperfusion injury by up-regulation of HIF-1 alpha expression and binding activity.
Ke et al., Nantong, China. In Biochim Biophys Acta, 2010
In the present study, we demonstrated for the first time that 6 h of hyperthermia (38°C or 40°C) could induce a characteristic "reactive" morphology and a significant increase in the expression of bystin in astrocytes.
Expression and Localization of an Hsp70 Protein in the Microsporidian Encephalitozoon cuniculi.
Hayman et al., Johnson City, United States. In Int J Microbiol, 2009
In spore adherence inhibition assays, the anti-C1 antibodies did not inhibit spore adherence to host cell surfaces, whereas antibodies to a known surface adhesin (EnP1) did so.
Trophinin: what embryo implantation teaches us about human cancer.
Nakayama et al., Los Angeles, United States. In Cancer Biol Ther, 2008
This review describes trophinin, a cell adhesion/signaling protein, and its associated proteins, bystin and tastin, the proteins potentially involved in human embryo implantation, and presents examples of trophinin-expressing cancers.
The role of bystin in embryo implantation and in ribosomal biogenesis.
Nadano et al., Los Angeles, United States. In Cell Mol Life Sci, 2008
review of the roles of bystin in embryo implantation, assembly of ribosomes, and as a target of c-MYC
Bystin in human cancer cells: intracellular localization and function in ribosome biogenesis.
Nadano et al., Nagoya, Japan. In Biochem J, 2007
These results suggest that, while bystin may play multiple roles in mammalian cells, a conserved function is to facilitate ribosome biogenesis required for cell growth.
Crucial role of Bysl in mammalian preimplantation development as an integral factor for 40S ribosome biogenesis.
Iwakura et al., Tokyo, Japan. In Mol Cell Biol, 2007
findings provide evidence for a crucial role of Bysl as an integral factor for ribosome biogenesis and suggest a critical dependence of blastocyst formation on active translation machinery
The Bysl gene product, bystin, is essential for survival of mouse embryos.
Fukuda et al., Los Angeles, United States. In Febs Lett, 2006
Bystin is expressed in luminal and glandular epithelia in the mouse uterus at peri-implantation stages. Targeted disruption of the moBysl resulted in embryonic lethality shortly after implantation.
Recent molecular approaches to elucidate the mechanism of embryo implantation: trophinin, bystin, and tastin as molecules involved in the initial attachment of blastocysts to the uterus in humans.
Fukuda et al., Los Angeles, United States. In Semin Reprod Med, 1999
Instead of using human materials during the implantation period, two human tumor cell lines that respectively mimic the biological behaviors of a blastocyst and uterine luminal epithelial cells were utilized successfully to identify three novel adhesion molecules named trophinin, bystin, and tastin.
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